In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas.

Abstract:

:Histone modification has emerged as a promising approach to cancer therapy. We explored the in vivo efficacy of a butyric acid derivative, pivaloyloxymethyl butyrate (AN-9), for the treatment of gliomas. Relative to control and single-modality treatments, the combination of AN-9 and radiation significantly inhibited tumor growth and prolonged time to failure in mice bearing glioma xenografts. The enhanced response to radiation was accompanied by inhibition of cellular proliferation and by increased phosphorylation of H2AX, implicating DNA double-strand breaks in the antineoplastic effects of AN-9 and radiation. The data suggest that AN-9 in combination with radiation may be an effective therapy for malignant gliomas.

journal_name

Neuro Oncol

journal_title

Neuro-oncology

authors

Entin-Meer M,Yang X,VandenBerg SR,Lamborn KR,Nudelman A,Rephaeli A,Haas-Kogan DA

doi

10.1215/15228517-2006-032

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

82-8

issue

2

eissn

1522-8517

issn

1523-5866

pii

15228517-2006-032

journal_volume

9

pub_type

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