Abstract:
:Histone modification has emerged as a promising approach to cancer therapy. We explored the in vivo efficacy of a butyric acid derivative, pivaloyloxymethyl butyrate (AN-9), for the treatment of gliomas. Relative to control and single-modality treatments, the combination of AN-9 and radiation significantly inhibited tumor growth and prolonged time to failure in mice bearing glioma xenografts. The enhanced response to radiation was accompanied by inhibition of cellular proliferation and by increased phosphorylation of H2AX, implicating DNA double-strand breaks in the antineoplastic effects of AN-9 and radiation. The data suggest that AN-9 in combination with radiation may be an effective therapy for malignant gliomas.
journal_name
Neuro Oncoljournal_title
Neuro-oncologyauthors
Entin-Meer M,Yang X,VandenBerg SR,Lamborn KR,Nudelman A,Rephaeli A,Haas-Kogan DAdoi
10.1215/15228517-2006-032subject
Has Abstractpub_date
2007-04-01 00:00:00pages
82-8issue
2eissn
1522-8517issn
1523-5866pii
15228517-2006-032journal_volume
9pub_type
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