Abstract:
:In patients with parenchymal brain masses of uncertain origin responsive to corticosteroids, primary CNS lymphoma (PCNSL) should be considered. PCNSL is a rare but aggressive brain tumor that is highly sensitive to high-dose methotrexate (HDMTX)-based chemotherapy. We report a series of six patients with brain masses without histologic confirmation suspicious for PCNSL based on clinical and radiomorphologic criteria after exclusion of some infectious conditions. All patients were treated with HDMTX. We observed two complete responses, two partial responses, and one stable disease. One patient had progressive disease and received rescue whole-brain irradiation. All patients were alive without disease progression 12-48 months after HDMTX start. No symptoms of late neurotoxicity have occurred so far. The response and survival data in this small series of patients are encouraging and suggest a benefit for patients with suspected PCNSL after initial treatment with HDMTX.
journal_name
Neuro Oncoljournal_title
Neuro-oncologyauthors
Kiewe P,Loddenkemper C,Anagnostopoulos I,Reinwald M,Thiel E,Korfel Adoi
10.1215/15228517-2006-037subject
Has Abstractpub_date
2007-04-01 00:00:00pages
96-102issue
2eissn
1522-8517issn
1523-5866pii
15228517-2006-037journal_volume
9pub_type
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