A beta oligomers - a decade of discovery.

Abstract:

:Converging lines of evidence suggest that progressive accumulation of the amyloid beta-protein (A beta) plays a central role in the genesis of Alzheimer's disease, but it was long assumed that A beta had to be assembled into extracellular amyloid fibrils to exert its cytotoxic effects. Over the past decade, data have emerged from the use of synthetic A beta peptides, cell culture models, beta-amyloid precursor protein transgenic mice and human brain to suggest that pre-fibrillar, diffusible assemblies of A beta are also deleterious. Although the precise molecular identity of these soluble toxins remains unsettled, accumulating evidence suggests that soluble forms of A beta are indeed the proximate effectors of synapse loss and neuronal injury. Here we review recent progress in understanding the role of soluble oligomers in Alzheimer's disease.

journal_name

J Neurochem

authors

Walsh DM,Selkoe DJ

doi

10.1111/j.1471-4159.2006.04426.x

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

1172-84

issue

5

eissn

0022-3042

issn

1471-4159

pii

JNC4426

journal_volume

101

pub_type

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