Abstract：
:A major concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles and noted that the resulting groupings differ but still reflect mechanism of action. The present paper shows that these discrepancies can be viewed as a weighting of drug-drug distances, the weights depending on which cell lines the two drugs differ in.
journal_name
J Chem Inf Modeljournal_title
Journal of chemical information and modelingauthors
Andersson CR,Fryknäs M,Rickardson L,Larsson R,Isaksson A,Gustafsson MGdoi
10.1021/ci060073nsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
239-48issue
1eissn
1549-9596issn
1549-960Xjournal_volume
47pub_type
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