Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.

abstract：:Cerebellar Purkinje cell (PC) loss is a consistent pathological finding in autism. However, neural mechanisms of PC-dysfunction in autism remain poorly characterized. Glutamate receptor interacting proteins 1/2 (Grip1/2) regulate AMPA receptor (AMPAR) trafficking and synaptic strength. To evaluate role of PC-AMPAR sig...

journal_title：Neurobiology of disease

authors： Mejias R,Chiu SL,Han M,Rose R,Gil-Infante A,Zhao Y,Huganir RL,Wang T

更新日期：2019-12-01 00:00:00

abstract：:Environmental toxicants and, in particular, pesticides have been implicated as risk factors in Parkinson's disease (PD). The purpose of this study was to determine if selective nigrostriatal degeneration could be reproduced by systemic exposure of mice to the widely used herbicide paraquat. Repeated intraperitoneal pa...

journal_title：Neurobiology of disease

authors： McCormack AL,Thiruchelvam M,Manning-Bog AB,Thiffault C,Langston JW,Cory-Slechta DA,Di Monte DA

更新日期：2002-07-01 00:00:00

abstract：:There is evidence that cognitive decline in Alzheimer's disease (AD) results from deficiencies in synaptic communication (e.g., loss of mushroom-shaped 'memory spines') and neurodegenerative processes. This might be treated with sigma-1 receptor (S1R) agonists, which are broadly neuroprotective and modulate synaptic p...

journal_title：Neurobiology of disease

authors： Ryskamp D,Wu L,Wu J,Kim D,Rammes G,Geva M,Hayden M,Bezprozvanny I

更新日期：2019-04-01 00:00:00

abstract：:The interest in the pedunculopontine tegmental nucleus (PPTg), a structure located in the brainstem at the level of the pontomesencephalic junction, has greatly increased in recent years because it is involved in the regulation of physiological functions that fail in Parkinson's disease and because it is a promising t...

journal_title：Neurobiology of disease

authors： Vitale F,Capozzo A,Mazzone P,Scarnati E

更新日期：2019-08-01 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative disorder involving progressive motor disturbances, cognitive decline, and desynchronized sleep-wake rhythms. Recent studies revealed that restoring normal sleep-wake cycles can improve cognitive function in HD mice, suggesting that some sleep/wake systems remain operati...

journal_title：Neurobiology of disease

authors： Williams RH,Morton AJ,Burdakov D

更新日期：2011-06-01 00:00:00

abstract：:Optic neuritis is a frequent and early symptom of multiple sclerosis (MS). Conventional magnetic resonance (MR) techniques provide means to assess multiple MS-related pathologies, including axonal injury, demyelination, and inflammation. A method to directly and non-invasively probe white-matter function could further...

journal_title：Neurobiology of disease

authors： Lin TH,Spees WM,Chiang CW,Trinkaus K,Cross AH,Song SK

更新日期：2014-07-01 00:00:00

abstract：:The hyh mouse carrying a point mutation in the gene encoding for soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein alpha (alpha-SNAP) develops inherited hydrocephalus. The investigation was designed to study: (i) the clinical evolution of hyh mice; (ii) factors other than the alpha-SNAP mutation that ...

journal_title：Neurobiology of disease

authors： Bátiz LF,Páez P,Jiménez AJ,Rodríguez S,Wagner C,Pérez-Fígares JM,Rodríguez EM

更新日期：2006-07-01 00:00:00

abstract：:Clinical studies indicate that phenytoin prevents acute post-traumatic seizures but not subsequent post-traumatic epilepsy. We explored this phenomenon using organotypic hippocampal slice cultures as a model of severe traumatic brain injury. Hippocampal slices were cultured for up to eight weeks, during which acute an...

journal_title：Neurobiology of disease

authors： Berdichevsky Y,Dzhala V,Mail M,Staley KJ

更新日期：2012-02-01 00:00:00

abstract：:Excitotoxicity plays a central role in the neuronal damage during ischemic stroke. Although growing evidence suggests that activation of extrasynaptic NMDA receptors initiates neuronal death, no direct evidence demonstrated their activation during ischemia. Using rat hippocampal slices, we detected oxygen-glucose depr...

journal_title：Neurobiology of disease

authors： Dong QP,He JQ,Chai Z

更新日期：2013-10-01 00:00:00

abstract：:This report is devoted to the characterization of the apolipoprotein E (ApoE) in Microcebus murinus. Only one allele homologous to the human ApoE4 allele was evidenced. The distribution of the corresponding ApoE protein in the brain was found in association with the pathological proteins characteristic of Alzheimer's ...

journal_title：Neurobiology of disease

authors： Calenda A,Jallageas V,Silhol S,Bellis M,Bons N

更新日期：1995-06-01 00:00:00

abstract：:Niemann-Pick disease type C (NPC) is an inherited lysosomal storage disease characterised by accumulation of cholesterol and glycosphingolipids. NPC patients suffer a progressive neurodegenerative phenotype presenting with motor dysfunction, mental retardation and cognitive decline. To examine the onset and progressio...

journal_title：Neurobiology of disease

authors： Pressey SN,Smith DA,Wong AM,Platt FM,Cooper JD

更新日期：2012-03-01 00:00:00

abstract：:Butyrylcholinesterase (BChE) genotypes and protein (BuChE) activity, especially in combination with Apolipoprotein E4 (ApoE4), have been investigated as risk factors for developing Alzheimer disease (AD) and may be associated with the rate of progression of cognitive decline. Despite similar pathologic (e.g. amyloid d...

journal_title：Neurobiology of disease

authors： Maetzler W,Keller S,Michelis J,Koehler N,Stransky E,Becker C,Schulte C,Melms A,Gasser T,Berg D

更新日期：2009-08-01 00:00:00

abstract：:Human apolipoprotein E (apoE) exists in three isoforms: apoE2, apoE3 and apoE4. APOE ε4 is a major genetic risk factor for cardiovascular disease (CVD) and Alzheimer's disease (AD). ApoE mediates cholesterol metabolism by binding various receptors. The low-density lipoprotein receptor (LDLR) has a high affinity for ap...

journal_title：Neurobiology of disease

authors： Johnson LA,Olsen RH,Merkens LS,DeBarber A,Steiner RD,Sullivan PM,Maeda N,Raber J

更新日期：2014-04-01 00:00:00

abstract：:Voltage-gated sodium channels (VGSCs) are essential for the generation and propagation of action potentials in electrically excitable cells. Dominant mutations in SCN1A, which encodes the Nav1.1 VGSC α-subunit, underlie several forms of epilepsy, including Dravet syndrome (DS) and genetic epilepsy with febrile seizure...

journal_title：Neurobiology of disease

authors： Dutton SB,Makinson CD,Papale LA,Shankar A,Balakrishnan B,Nakazawa K,Escayg A

更新日期：2013-01-01 00:00:00

abstract：:The brain of Alzheimer's disease patients shows abundant dystrophic neurites in close proximity to fibrillar beta-amyloid (A beta) plaques, and activated glial cells. We evaluated the influence of pro-inflammatory molecules (LPS + IFN-gamma) on A beta(1-42) neurotoxicity. 2 microM A beta(1-42) induced apoptosis of hip...

journal_title：Neurobiology of disease

authors： Ramírez G,Toro R,Döbeli H,von Bernhardi R

更新日期：2005-06-01 00:00:00

abstract：:Levodopa (L-DOPA) remains the most effective pharmacological treatment for Parkinson Disease (PD) but its use is limited by the development of debilitating drug-related side effects, particularly L-DOPA induced dyskinesia (LID). LID is a consequence of long-term L-DOPA use, and in model systems is characterized by a "...

journal_title：Neurobiology of disease

authors： A Figge D,Standaert DG

更新日期：2017-06-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic, inflammatory autoimmune disease that affects the central nervous system (CNS) for which there is no cure. In MS, encephalitogenic T cells infiltrate the CNS causing demyelination and neuroinflammation; however, little is known about the role of regulatory T cells (Tregs) in CNS ti...

journal_title：Neurobiology of disease

authors： McIntyre LL,Greilach SA,Othy S,Sears-Kraxberger I,Wi B,Ayala-Angulo J,Vu E,Pham Q,Silva J,Dang K,Rezk F,Steward O,Cahalan MD,Lane TE,Walsh CM

更新日期：2020-07-01 00:00:00

abstract：:Type 2 diabetes (T2D) is a major risk factor for late-onset Alzheimer's disease (AD). A variety of metabolic changes related to T2D (e.g. hyperinsulinemia, hyperglycemia, and elevated branched-chain amino acids) have been proposed as mechanistic links, but the basis for this association remains unknown. Retromer-depen...

journal_title：Neurobiology of disease

authors： Morabito MV,Berman DE,Schneider RT,Zhang Y,Leibel RL,Small SA

更新日期：2014-05-01 00:00:00

abstract：:Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial (FALS), and approximately 25% of FALS cases are caused by mutations in superoxide dismutase-1 (SOD1). Mutant (MT) SOD1 kills motor neurons because of the mutant protein's toxicity; however, the basis for toxicity is unknown. We electroporated ...

journal_title：Neurobiology of disease

authors： Ghadge GD,Wang L,Sharma K,Monti AL,Bindokas V,Stevens FJ,Roos RP

更新日期：2006-01-01 00:00:00

abstract：:The telomeric copy of the survival motor neuron gene (SMN1) is deleted or mutated in all spinal muscular atrophy (SMA) patients and these patients present mainly a loss in spinal motoneurons. Although studies performed in HeLa cells suggest that SMN may be involved in the biogenesis and possibly in recycling of splice...

journal_title：Neurobiology of disease

authors： Cisterni C,Kallenbach S,Jordier F,Bagnis C,Pettmann B

更新日期：2001-04-01 00:00:00

abstract：:Based on in vitro studies, it is hypothesized that neurotrophic factor deprivation following deafferentation elicits an oxidative state change in the deafferented neuron and the formation of free radicals that then signal cell death pathways. This pathway to cell death was tested in vivo by assessing the efficacy of a...

journal_title：Neurobiology of disease

authors： Maruyama J,Yamagata T,Ulfendahl M,Bredberg G,Altschuler RA,Miller JM

更新日期：2007-02-01 00:00:00

abstract：:Toll-like receptors (TLRs) are mediators of the innate immune response to exogenous pathogens. They have also been implicated in sterile inflammation associated with systemic injury and non-infectious diseases via binding of endogenous ligands, possibly released by damaged cells. Emerging evidence indicates that some ...

journal_title：Neurobiology of disease

authors： David BT,Ratnayake A,Amarante MA,Reddy NP,Dong W,Sampath S,Heary RF,Elkabes S

更新日期：2013-06-01 00:00:00

abstract：:Several reports indicate that the activity of the hypothalamic–pituitary–adrenal axis (HPA) is increased after a brain insult and that its down-regulation can improve detrimental outcomes associated with ischemic brain injuries.Granulocyte-colony stimulating factor (G-CSF) is a neuroprotective drug shown in the naïve ...

journal_title：Neurobiology of disease

authors： Charles MS,Ostrowski RP,Manaenko A,Duris K,Zhang JH,Tang J

更新日期：2012-07-01 00:00:00

abstract：:The pathophysiology of Parkinson's disease (PD) and of L-DOPA-induced dyskinesia (LID) is associated with dysfunctional neuronal activity in several nuclei of the basal ganglia. Moreover, high levels of oscillatory activity and synchronization have also been described in both intra- and inter-basal ganglia nuclei and ...

journal_title：Neurobiology of disease

authors： Aristieta A,Ruiz-Ortega JA,Miguelez C,Morera-Herreras T,Ugedo L

更新日期：2016-05-01 00:00:00

abstract：:Symptoms in Parkinson's Disease (PD) have been linked to oscillatory activity within the basal ganglia. In humans, such activity has been detected mainly in the local field potentials (LFPs) recorded from electrode contacts used for deep brain stimulation. Although most studies have focused on activity within the subt...

journal_title：Neurobiology of disease

authors： Tsiokos C,Hu X,Pouratian N

更新日期：2013-06-01 00:00:00

abstract：:Apoptosis is triggered in the developing mammalian brain by sedative, anesthetic or antiepileptic drugs during late gestation and early life. Whether human children are vulnerable to this toxicity mechanism remains unknown, as there are no imaging techniques to capture it. Apoptosis is characterized by distinct struct...

journal_title：Neurobiology of disease

authors： Rosado-Mendez IM,Noguchi KK,Castañeda-Martinez L,Kirvassilis G,Wang SH,Manzella F,Swiney BS,Masuoka K,Capuano S III2,Brunner KG,Crosno K,Guerrero QW,Whitson H,Brambrink A,Simmons HS,Mejia AF,Zagzebski JA,Hall TJ,Ikono

更新日期：2019-07-01 00:00:00

abstract：:TAR-DNA binding protein 43 (TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic lateral sclerosis (ALS). Previous studies have demonstrated that loss of TDP-43 function leads to intracellular accumulation of non-coding repetitive element transcripts and double-stranded R...

journal_title：Neurobiology of disease

authors： LaRocca TJ,Mariani A,Watkins LR,Link CD

更新日期：2019-12-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are involved in tissue repair, cell death and morphogenesis. We investigated the role of the gelatinases MMP-2 and MMP-9 in the pathogenesis of neuronal death induced by prolonged seizures in the developing brain. Seven-day-old rats, MMP-9 knockout mice and transgenic rats overexpressi...

journal_title：Neurobiology of disease

authors： Hoehna Y,Uckermann O,Luksch H,Stefovska V,Marzahn J,Theil M,Gorkiewicz T,Gawlak M,Wilczynski GM,Kaczmarek L,Ikonomidou C

更新日期：2012-12-01 00:00:00

abstract：:We identified a novel spontaneous mutant mouse showing motor symptoms that are similar to those of the dystonia musculorum (dt) mouse. The observations suggested that the mutant mice inherited the mild dt phenotype as an autosomal recessive trait. Linkage analysis showed that the causative gene was located near D1Mit3...

journal_title：Neurobiology of disease

authors： Horie M,Mekada K,Sano H,Kikkawa Y,Chiken S,Someya T,Saito K,Hossain MI,Nameta M,Abe K,Sakimura K,Ono K,Nambu A,Yoshiki A,Takebayashi H

更新日期：2016-12-01 00:00:00

abstract：:Several neurodegenerative diseases like Huntington's, a polyglutamine (PolyQ) disease, are initiated by protein aggregation in neurons. Furthermore, these diseases are also associated with a multitude of responses in non-neuronal cells in the brain, in particular glial cells, like astrocytes. These non-neuronal respon...

journal_title：Neurobiology of disease

authors： Bason M,Meister-Broekema M,Alberts N,Dijkers P,Bergink S,Sibon OCM,Kampinga HH

更新日期：2019-04-01 00:00:00