Abstract:
:Polyadenylation of nascent transcripts is one of the key mRNA processing events in eukaryotic cells. A large number of human and mouse genes have alternative polyadenylation sites, or poly(A) sites, leading to mRNA variants with different protein products and/or 3'-untranslated regions (3'-UTRs). PolyA_DB 2 contains poly(A) sites identified for genes in several vertebrate species, including human, mouse, rat, chicken and zebrafish, using alignments between cDNA/ESTs and genome sequences. Several new features have been added to the database since its last release, including syntenic genome regions for human poly(A) sites in seven other vertebrates and cis-element information adjacent to poly(A) sites. Trace sequences are used to provide additional evidence for poly(A/T) tails in cDNA/ESTs. The updated database is intended to broaden poly(A) site coverage in vertebrate genomes, and provide means to assess the authenticity of poly(A) sites identified by bioinformatics. The URL for this database is http://polya.umdnj.edu/PolyA_DB2.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Lee JY,Yeh I,Park JY,Tian Bdoi
10.1093/nar/gkl870subject
Has Abstractpub_date
2007-01-01 00:00:00pages
D165-8issue
Database issueeissn
0305-1048issn
1362-4962pii
35/suppl_1/D165journal_volume
35pub_type
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