Abstract：
:Previous studies have found that smoking is a strong factor that increases peripheral blood CD4+ T lymphocytes. However, most studies did not assess the cumulative long-life exposure of smoking on differential lymphocyte populations. In this study, to clarify the association of smoking habits and circulating lymphocytes, we conducted a cross-sectional study of 60 male current smokers. Smoking status was estimated by number of cigarettes smoked per day, smoking years, and Brinkman Index (BI) as calculated by multiplying the number of cigarettes smoked per day by the smoking years. Counts of CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes were strongly and positively correlated with BI and remained highly significant after controlling for alcohol drinking, leisure-time physical activity, and caffeine intake (r(p)>.465, p<.001). These lymphocytes were also significantly correlated with the number of cigarettes smoked per day and smoking years, but the association was weaker than the BI. The findings suggest that the CD4+CD45RO+CD69+ T and CD4+CD45RO+ T lymphocytes are sensitive to cumulative effect of smoking, and may serve as a potential immuno-biomarker for active smoking.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Nakata A,Takahashi M,Irie M,Fujioka Y,Haratani T,Araki Sdoi
10.1016/j.addbeh.2006.11.007subject
Has Abstractpub_date
2007-07-01 00:00:00pages
1526-31issue
7eissn
0306-4603issn
1873-6327pii
S0306-4603(06)00340-6journal_volume
32pub_type
杂志文章abstract：:When symptomatic individuals selectively attend to emotionally relevant stimuli, the ability to shift attention away from such material is impaired. Subjects may, however, seek to avoid further processing of these stimuli, which would facilitate attentional shifts. This was examined in a group of abstinent alcoholics'...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章
doi：10.1016/s0306-4603(96)00051-2
更新日期：1997-07-01 00:00:00
abstract：:Rates of alcohol consumption are substantially higher among persons with pain, and recent research has focused on elucidating bidirectional pain-alcohol effects. Expectancies for alcohol analgesia could influence the degree to which alcohol confers acute pain-relieving effects, and may amplify the propensity to respon...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2021.106822
更新日期：2021-01-08 00:00:00
abstract：:This study examined associations between substance use behaviors and self-reported health among hospitalized heroin users. Of the 112 participants, 53 (47%) reported good or better health. In multivariable logistic regression models, each day of heroin use in the last month was associated with an 8% lower odds of repo...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2013.08.002
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Prior research indicates that Latino immigrants are less likely than US-born individuals to use alcohol and meet criteria for an alcohol use disorder. However, our understanding of alcohol-related problem behaviors among Latino immigrants remains limited. We report the prevalence of alcohol-related problem b...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.06.031
更新日期：2018-12-01 00:00:00
abstract：:Many cigarette smokers appear to experience ambivalence about smoking, defined as the simultaneous co-occurrence of a strong desire to smoke and a strong wish to quit smoking. Research suggests that this ambivalence about smoking affects how smokers respond to cigarette-related stimuli, but many important questions re...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2012.03.020
更新日期：2013-02-01 00:00:00
abstract：:The prediction of resumption of drinking in posttreatment alcoholics was investigated as a function of five possible confounding variables: depression, anxiety, childhood symptoms of attention deficit and conduct disorders and family history of alcoholism. Male and female detoxified alcoholics (n = 103) in inpatient t...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(90)90073-7
更新日期：1990-01-01 00:00:00
abstract：:The present study assessed patterns of multiple drug use among a sample of university employees and students who had been identified as having moderately high drug use habits. Use of eleven categories of legal and illegal drugs was tested and subjects reported how much of each drug they currently and habitually used. ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(89)90022-1
更新日期：1989-01-01 00:00:00
abstract：:Approximately 20% of high school students and 7% of middle school students in the United States used tobacco products in 2016. One factor that may contribute to tobacco use is pleasant sensations - typically characterized as physiological reinforcement such as a dopamine response, or as social reinforcement such as so...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.10.003
更新日期：2019-02-01 00:00:00
abstract：:Research has indicated that individuals high in social comparison orientation (SCO) are more influenced by the behavior and perceived norms of others. However, despite research indicating that behavior is more closely influenced by and modeled on more socially proximal reference groups, most social comparison research...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.10.029
更新日期：2019-03-01 00:00:00
abstract：INTRODUCTION:College student drinkers have the propensity to engage in heavy alcohol consumption. These consumption patterns can be problematic given the well-established relationship between heavy drinking and negative consequences of alcohol consumption. Though the research on college student drinking is abundant, mu...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.02.004
更新日期：2015-07-01 00:00:00
abstract：:Incarcerated adolescents' attributions for drug use were investigated. A new 50-item questionnaire, the Inventory of Drug Taking Situations (IDTS), was used to assess reasons for use. The IDTS yields eight subscales corresponding to risky situations identified by Marlatt and others. On the IDTS, subjects indicate how ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(92)90028-t
更新日期：1992-01-01 00:00:00
abstract：:Tobacco use is greater among young adults who binge drink; yet there is limited research on tobacco use characteristics among different types of binge drinkers based on frequency. We aimed to characterize this relationship among young adults (18-25years old) who used both substances in the past month (smoked ≥1 cigare...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2016.04.019
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:Anxiety sensitivity (AS)-the tendency to fear anxiety-related experiences-is a risk factor for anxiety disorders and may contribute to smoking motivation and maintenance. Few studies have examined the relations between conceptually distinct components of AS and smoking behavior. The purpose of the current ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.08.004
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Previous results suggested that alcohol abusers and alcohol dependent patients show cognitive biases in the treatment of alcohol-related cues, especially approach and inhibition deficit biases. Response inhibition was often tested using the go/no-go task in which the participants had to respond as quickly as...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2013.04.007
更新日期：2013-10-01 00:00:00
abstract：INTRODUCTION:Overdose is a leading cause of injury and death in the United States. Emergency Department (ED) patients have an elevated prevalence of substance use. This study describes overdose/adverse drug event experiences among adult ED patients to inform strategies to address overdose risk. METHODS:Patients seekin...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.11.030
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Enhanced reactivity to substance related cues is a central characteristic of addiction and has been associated with increased activity in motivation, attention, and memory related brain circuits and with a higher probability of relapse. Modafinil was promising in the first clinical trials in cocaine dependenc...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2012.04.006
更新日期：2013-02-01 00:00:00
abstract：:Women with drinking problems are less likely than men to utilize alcohol-specific treatment services; they are comparatively more likely to seek help in general health and mental health care settings. These patterns in service utilization may be attributable, in part, to gender differences in barriers or disincentives...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/0306-4603(95)00041-0
更新日期：1996-01-01 00:00:00
abstract：:Treatment for drug use, like the process by which a person comes to use illicit drugs, may be seen to be at least in part a psychosocial process involving emotional, cognitive, and relationship domains. Treatment programs attempt to improve the psychosocial functioning of clients with the ultimate goal of effecting ch...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(95)00098-4
更新日期：1996-09-01 00:00:00
abstract：:The purpose of the present study was to determine the association between smoking and body weight in a cohort of young U.S. Air Force recruits (mean age=20 years) enrolled in basic military training (N=35986). Twenty-two percent of recruits smoked daily prior to basic military training (n=8087) and were compared to ne...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/j.addbeh.2008.11.015
更新日期：2009-04-01 00:00:00
abstract：:Treatment studies provide minimal support for nicotine replacement therapy (NRT) with youth; however, survey studies suggest that adolescents use NRT, and may engage in inappropriate use. The current study sought to examine patterns of NRT use and risk factors for use to further aid smoking cessation efforts including...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2009.09.024
更新日期：2010-02-01 00:00:00
abstract：:Research has shown that metacognitions are associated with addictive behaviors. This study aimed to evaluate the psychometric properties (i.e., factor structure, reliability, and predictive validity) of the Persian Metacognitions about Smartphone Use Questionnaire (Persian MSUQ). A community sample of 618 participants...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106722
更新日期：2021-03-01 00:00:00
abstract：:Parents, public health officials, college personnel, and society at-large continue to be concerned about the increase in heavy drinking that occurs across the transition to college, prompting alcohol researchers to continue the search for effective interventions. In this report we use data from a large (N=3720) prospe...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.06.024
更新日期：2007-04-01 00:00:00
abstract：:The aim of this study was to examine the effectiveness of low-magnitude behavioral incentives in improving attendance for abstinence-treated patients and sustaining illicit-drug abstinence for methadone-treated patients. Subjects were randomly assigned to either incentive or control conditions, with target behaviors d...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0306-4603(98)00119-1
更新日期：2000-03-01 00:00:00
abstract：:Results from a study using the balanced placebo design to assess alcohol's effects on anxiety raise serious doubts about the utility of the design even at moderate blood alcohol concentrations. Despite being informed that they were not drinking alcohol, 44% of the subjects who were administered alcohol reported consum...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(94)90034-5
更新日期：1994-05-01 00:00:00
abstract：:Adolescence is a time of physical and mental development when small changes can impact on the rest of a person's life. Substance use in this crucial period can have long-lasting consequences for the individual and for society. The prevalence of substance use in young people is an area of concern for policy makers and ...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/j.addbeh.2013.03.016
更新日期：2013-08-01 00:00:00
abstract：:The negative impact of alcohol is a significant concern to the US military given the costs associated with alcohol-related offenses. Despite considerable research in active duty personnel, relatively little is known about the current extent of alcohol use among incoming recruits. We examined the history of alcohol use...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2016.02.028
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:Specific events (e.g., Spring Break, holidays) are associated with greater college student drinking. However, the ways in which specific events are celebrated at specific campuses may impact students' beliefs about the social acceptability of drinking during these events, which may impact students' event-spec...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.01.033
更新日期：2015-06-01 00:00:00
abstract：:The present study sought to determine whether the high relapse rates observed among subjects in fixed length behavioral-based weight loss programs would be lowered if subjects were allowed to continue in treatment until they had reached their desired weights. Five hundred seventeen (517) clients at a commercial weight...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(92)90007-i
更新日期：1992-09-01 00:00:00
abstract：:Internet addiction (IA) is a condition characterized by loss of control over Internet use, leading to a variety of negative psychosocial consequences. Recent neuroimaging studies have begun to identify IA-related changes in specific brain regions and connections. However, whether and how the interactions within and be...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.01.021
更新日期：2017-07-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is highly prevalent in substance use disorder (SUD) populations. Because resources for extensive and thorough diagnostic assessment are often limited, reliable screening instruments for PTSD are needed. The aim of the current study was to test two short PTSD measures for diagnostic...
journal_title：Addictive behaviors
pub_type： 杂志文章,多中心研究
doi：10.1016/j.addbeh.2012.10.011
更新日期：2013-03-01 00:00:00
