当前位置： SCI文献检索 > JOURNAL OF MOLECULAR BIOLOGY期刊下所有文献 > Serpin acceleration of amyloid fibril formation: a role for accessory proteins.

Serpin acceleration of amyloid fibril formation: a role for accessory proteins.

Abstract：

:Protein aggregation underlies an increasing number of human diseases. Recent experiments have shown that the aggregation reaction is exquisitely specific involving particular interactions between non-native proteins. However, aggregation of certain proteins, for example beta-amyloid, in vivo leads to the recruitment of other proteins into the aggregate. Antichymotrypsin, a non-fibril forming protein, is always observed to be associated with beta-amyloid plaques in Alzheimer's sufferers. The role of antichymotrypsin is controversial with studies showing it can either accelerate or inhibit the aggregation reaction. To investigate the role of antichymotrypsin in fibrillogenesis we have studied its interaction with apolipoprotein C-II, a well characterized model system for the study of fibrillogenesis. Our data demonstrate that sub-stoichiometric amounts of antichymotrypsin and its alternate structural forms can dramatically accelerate the aggregation of apolipoprotein C-II, whereas the presence of alpha(1)-antitrypsin, a structural homologue of antichymotrypsin, cannot. Sedimentation velocity experiments show more apolipoprotein C-II fibrils were formed in the presence of antichymotrypsin. Using pull-down assays and immuno-gold labeling we demonstrate an interaction between antichymotrypsin and apolipoprotein C-II fibrils that specifically occurs during fibrillogenesis. Taken together these data demonstrate an interaction between antichymotrypsin and apolipoprotein C-II that accelerates fibrillogenesis and indicates a specific role for accessory proteins in protein aggregation.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Powers GA,Pham CL,Pearce MC,Howlett GJ,Bottomley SP

doi

10.1016/j.jmb.2006.11.062

subject

Has Abstract

pub_date

2007-02-16 00:00:00

pages

666-76

issue

2

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(06)01609-3

journal_volume

366

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR BIOLOGY文献大全
  • Zooming in on Transcription Preinitiation.

    abstract：:Class II gene transcription commences with the assembly of the Preinitiation Complex (PIC) from a plethora of proteins and protein assemblies in the nucleus, including the General Transcription Factors (GTFs), RNA polymerase II (RNA pol II), co-activators, co-repressors, and more. TFIID, a megadalton-sized multiprotei...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jmb.2016.04.003

    authors： Gupta K,Sari-Ak D,Haffke M,Trowitzsch S,Berger I

    更新日期：2016-06-19 00:00:00

  • Dynamical characterization of two differentially disease associated MHC class I proteins in complex with viral and self-peptides.

    abstract：:Major histocompatibility complex (MHC) class I proteins are expressed on the cell surface where they present foreign and self-peptides to effector cells of the immune system. While an understanding of the structural prerequisites for antigen presentation has already been achieved, insight into subtype- or peptide-depe...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2011.11.021

    authors： Narzi D,Becker CM,Fiorillo MT,Uchanska-Ziegler B,Ziegler A,Böckmann RA

    更新日期：2012-01-13 00:00:00

  • Contributions of Histone Variants in Nucleosome Structure and Function.

    abstract：:Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and H4, and 145-147 base pairs of DNA. Since replication, recombination, repair, and transcription take place in chromatin, the structure and dynamics of ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jmb.2020.10.012

    authors： Kurumizaka H,Kujirai T,Takizawa Y

    更新日期：2020-10-14 00:00:00

  • Involvement of a stem-loop structure in the location of junction sites in viral RNA recombination.

    abstract：:Recombination between RNAs associated with turnip crinkle virus is thought to occur during plus-strand synthesis at motifs resembling the 5'-ends of genomic, subgenomic and satellite RNAs. Common structural regions encompassing the motifs have been found for major crossover sites on two different minus-strand template...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1994.0050

    authors： Carpenter CD,Oh JW,Zhang C,Simon AE

    更新日期：1995-02-03 00:00:00

  • Intrahelical hydrogen bonding of serine, threonine and cysteine residues within alpha-helices and its relevance to membrane-bound proteins.

    abstract：:A survey of known protein structures reveals that approximately 70% of serine residues and at least 85% (potentially 100%) of threonine residues in helices make hydrogen bonds to carbonyl oxygen atoms in the preceding turn of the helix. The high frequency of intrahelical hydrogen bonding is of particular significance ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(84)90446-7

    authors： Gray TM,Matthews BW

    更新日期：1984-05-05 00:00:00

  • The periplasmic binding protein of a tripartite tricarboxylate transporter is involved in signal transduction.

    abstract：:A new type of solute importer has been identified recently in various bacterial genera and called the tripartite tricarboxylate transporter (TTT). TTTs consist of two cytoplasmic membrane proteins and a periplasmic solute-binding protein. In the whooping cough agent Bordetella pertussis, a TTT system that has been cal...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2005.05.071

    authors： Antoine R,Huvent I,Chemlal K,Deray I,Raze D,Locht C,Jacob-Dubuisson F

    更新日期：2005-08-26 00:00:00

  • Self-association of a high molecular weight subfragment-2 of myosin induced by divalent metal ions.

    abstract：:The effect of divalent cations on the self-association of high molecular weight subfragment-2 (long S-2) and low molecular weight subfragment-2 (short S-2) of rabbit skeletal muscle myosin has been investigated. In the presence of millimolar concentrations of Ca2+ or Mg2+ long S-2 associates at neutral pH to form orde...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/s0022-2836(83)80015-1

    authors： Ueno H,Rodgers ME,Harrington WF

    更新日期：1983-08-05 00:00:00

  • Recognition of protein substrates by the prolyl isomerase trigger factor is independent of proline residues.

    abstract：:The trigger factor is associated with bacterial ribosomes and catalyzes proline-limited protein folding reactions. Its folding activity is very high and conserved in evolution, as shown for the homologous enzymes from Escherichia coli and Mycoplasma genitalium. The folding protein substrate (a variant of ribonuclease ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1997.1604

    authors： Scholz C,Mücke M,Rape M,Pecht A,Pahl A,Bang H,Schmid FX

    更新日期：1998-04-03 00:00:00

  • Bacterial repression loops require enhanced DNA flexibility.

    abstract：:The Escherichia coli lac operon provides a classic paradigm for understanding regulation of gene transcription. It is now appreciated that lac promoter repression involves cooperative binding of the bidentate lac repressor tetramer to pairs of lac operators via DNA looping. We have adapted components of this system to...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2005.04.035

    authors： Becker NA,Kahn JD,Maher LJ 3rd

    更新日期：2005-06-17 00:00:00

  • Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

    abstract：:Packaging of viral genomes inside empty procapsids is driven by a powerful ATP-hydrolyzing motor, formed in many double-stranded DNA viruses by a complex of a small terminase (S-terminase) subunit and a large terminase (L-terminase) subunit, transiently docked at the portal vertex during genome packaging. Despite rece...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2015.08.013

    authors： McNulty R,Lokareddy RK,Roy A,Yang Y,Lander GC,Heck AJR,Johnson JE,Cingolani G

    更新日期：2015-10-09 00:00:00

  • Dynamics of DNA loop capture by the SfiI restriction endonuclease on supercoiled and relaxed DNA.

    abstract：:The SfiI endonuclease is a prototype for DNA looping. It binds two copies of its recognition sequence and, if Mg(2+) is present, cuts both concertedly. Looping was examined here on supercoiled and relaxed forms of a 5.5 kb plasmid with three SfiI sites: sites 1 and 2 were separated by 0.4 kb, and sites 2 and 3 by 2.0 ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2004.03.046

    authors： Embleton ML,Vologodskii AV,Halford SE

    更新日期：2004-05-21 00:00:00

  • The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure pr

    abstract：:The type A domain of the von Willebrand Factor is found also in the complement proteins factor B (FB), C2, CR3 and CR4, the integrins, collagen types VI, VII, XII and XIV, and other proteins. FB is a component of the alternative pathway of the complement system of immune defence, and is cleaved into the fragments Bb a...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1994.1271

    authors： Perkins SJ,Smith KF,Williams SC,Haris PI,Chapman D,Sim RB

    更新日期：1994-04-22 00:00:00

  • Thermodynamic and kinetic basis for the relaxed DNA sequence specificity of "promiscuous" mutant EcoRI endonucleases.

    abstract：:Promiscuous mutant EcoRI endonucleases produce lethal to sublethal effects because they cleave Escherichia coli DNA despite the presence of the EcoRI methylase. Three promiscuous mutant forms, Ala138Thr, Glu192Lys and His114Tyr, have been characterized with respect to their binding affinities and first-order cleavage ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2005.02.051

    authors： Sapienza PJ,Dela Torre CA,McCoy WH 4th,Jana SV,Jen-Jacobson L

    更新日期：2005-04-29 00:00:00

  • Analysis of the backbone dynamics of interleukin-8 by 15N relaxation measurements.

    abstract：:The backbone dynamics of the cytokine interleukin-8, a symmetric homodimer of overall molecular mass 16 kDa, has been investigated at pH 5.2 by means of 15N relaxation measurements using heteronuclear two-dimensional inverse detected 1H-15N spectroscopy. 15N T1, T2 and NOE data were obtained for 66 out of a total of 6...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1993.1152

    authors： Grasberger BL,Gronenborn AM,Clore GM

    更新日期：1993-03-20 00:00:00

  • Some motile properties of fast characean myosin.

    abstract：:We improved a motility assay system by using an affinity-purified antibody against the C-terminal globular domain of characean myosin. This improvement allowed us to study the sensitivity to ionic strength or the processivity of characean myosin. The sliding velocity of actin filaments on a characean myosin-coated sur...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/s0022-2836(02)01469-9

    authors： Awata JY,Kashiyama T,Ito K,Yamamoto K

    更新日期：2003-02-21 00:00:00

  • Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.

    abstract：:The disulfide bond between Cys14 and Cys38 of bovine pancreatic trypsin inhibitor lies on the surface of the inhibitor and forms part of the protease-binding region. The functional properties of three variants lacking this disulfide, with one or both of the Cys residues replaced with Ser, were examined, and X-ray crys...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2008.07.063

    authors： Zakharova E,Horvath MP,Goldenberg DP

    更新日期：2008-10-17 00:00:00

  • Contribution of hydrophobic residues to the stability of human lysozyme: calorimetric studies and X-ray structural analysis of the five isoleucine to valine mutants.

    abstract：:In order to understand the contribution of hydrophobic residues to the conformational stability of human lysozyme, five Ile mutants (Ile --> Val) in the interior of the protein were constructed. The thermodynamic parameters characterizing the denaturation of these mutant proteins were determined by scanning calorimetr...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1995.0599

    authors： Takano K,Ogasahara K,Kaneda H,Yamagata Y,Fujii S,Kanaya E,Kikuchi M,Oobatake M,Yutani K

    更新日期：1995-11-17 00:00:00

  • Membrane biogenesis of subunit II of cytochrome bo oxidase: contrasting requirements for insertion of N-terminal and C-terminal domains.

    abstract：:The membrane assembly of the respiratory complexes requires the membrane insertases Oxa1 in mitochondria and YidC in bacteria. Oxa1 is responsible for the insertion of the mitochondrial cytochrome c oxidase subunit II (CoxII). Here, we investigated whether YidC, the bacterial Oxa1 homolog, plays a crucial role in the ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2006.01.030

    authors： Celebi N,Yi L,Facey SJ,Kuhn A,Dalbey RE

    更新日期：2006-04-14 00:00:00

  • Solution structure of carbonmonoxy myoglobin determined from nuclear magnetic resonance distance and chemical shift constraints.

    abstract：:Solution NMR structures for sperm whale carbonmonoxy myoglobin have been calculated using 1301 distance restraints determined from nuclear Overhauser enhancement (NOE) measurements on 15N-labeled protein and chemical shift calculations for 385 protons. Starting structures included four crystal forms of myoglobin and 1...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1994.1718

    authors： Osapay K,Theriault Y,Wright PE,Case DA

    更新日期：1994-11-25 00:00:00

  • Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins.

    abstract：:Hookworms are human parasites that have devastating effects on global health, particularly in underdeveloped countries. Ancylostoma ceylanicum infects humans and animals, making it a useful model organism to study disease pathogenesis. A. ceylanicum excretory-secretory protein 2 (AceES-2), a highly immunoreactive mole...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2011.02.033

    authors： Kucera K,Harrison LM,Cappello M,Modis Y

    更新日期：2011-04-22 00:00:00

  • Substrate preference of transglutaminase 2 revealed by logistic regression analysis and intrinsic disorder examination.

    abstract：:Tissue transglutaminase (TG2) catalyzes the Ca(2+)-dependent posttranslational modification of proteins via formation of isopeptide bonds between their glutamine and lysine residues. Although substrate specificity of TG2 has been studied repeatedly at the sequence level, no clear consensus sequences have been determin...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2008.08.026

    authors： Csosz E,Bagossi P,Nagy Z,Dosztanyi Z,Simon I,Fesus L

    更新日期：2008-11-07 00:00:00

  • Evaluation of the sequence template method for protein structure prediction. Discrimination of the (beta/alpha)8-barrel fold.

    abstract：:A multiple alignment of five (beta/alpha)8-barrel enzymes has been derived from their structure. The eight beta-strands and eight alpha-helices of the (beta/alpha)8-barrel are correctly aligned and the equivalenced residues in these regions fulfil similar structural roles. Each beta-strand has a central core of usuall...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(92)90499-a

    authors： Pickett SD,Saqi MA,Sternberg MJ

    更新日期：1992-11-05 00:00:00

  • Quaternary re-arrangement analysed by spectral enhancement: the interaction of a sporulation repressor with its antagonist.

    abstract：:The protein/protein interaction between SinI and SinR has been studied by analytical ultracentrifugation and gel electrophoresis in an attempt to understand how these proteins contribute to developmental control of sporulation in Bacillus subtilis. SinR was found to be tetrameric, while SinI was found to exist as mono...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.1999.3221

    authors： Scott DJ,Leejeerajumnean S,Brannigan JA,Lewis RJ,Wilkinson AJ,Hoggett JG

    更新日期：1999-11-12 00:00:00

  • FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties.

    abstract：:FUGUE, a program for recognizing distant homologues by sequence-structure comparison (http://www-cryst.bioc.cam.ac.uk/fugue/), has three key features. (1) Improved environment-specific substitution tables. Substitutions of an amino acid in a protein structure are constrained by its local structural environment, which ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1006/jmbi.2001.4762

    authors： Shi J,Blundell TL,Mizuguchi K

    更新日期：2001-06-29 00:00:00

  • A kinetic analysis of the nucleotide-induced allosteric transitions in a single-ring mutant of GroEL.

    abstract：:The function of GroE requires a complex system of allosteric communication driven by protein-nucleotide interactions. These rearrangements couple the binding and hydrolysis of ATP to an overall reaction cycle in which substrate proteins are bound, encapsulated and released. Positive cooperativity with respect to ATP b...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2004.03.010

    authors： Poso D,Clarke AR,Burston SG

    更新日期：2004-05-14 00:00:00

  • Tandemly repeated DNA sequences from Xenopus laevis. II. Dispersed clusters of a 388 base-pair repeating unit.

    abstract：:A repetitive DNA sequence family from Xenopus laevis that has an unusual genomic organization has been identified. It has been shown by blot-hybridization that this sequence occurs in clusters containing variable numbers of the 388 base-pair repeating unit. There are approximately 500 such clusters in the genome, and ...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/s0022-2836(83)80268-x

    authors： Lam BS,Carroll D

    更新日期：1983-04-25 00:00:00

  • Three-dimensional structure of rotavirus.

    abstract：:The three-dimensional structures of double and single-shelled simian rotavirus have been determined to a resolution of 40 A by image processing electron micrographs of unstained, unfixed virus particles embedded in vitreous ice. This study demonstrates that the icosahedral surface lattices in these structures have a t...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/0022-2836(88)90313-0

    authors： Prasad BV,Wang GJ,Clerx JP,Chiu W

    更新日期：1988-01-20 00:00:00

  • Islet amyloid polypeptide forms rigid lipid-protein amyloid fibrils on supported phospholipid bilayers.

    abstract：:Islet amyloid polypeptide (IAPP) forms fibrillar amyloid deposits in the pancreatic islets of Langerhans of patients with type 2 diabetes mellitus, and its misfolding and aggregation are thought to contribute to beta-cell death. Increasing evidence suggests that IAPP fibrillization is strongly influenced by lipid memb...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2007.11.077

    authors： Domanov YA,Kinnunen PK

    更新日期：2008-02-08 00:00:00

  • A miniprotein scaffold used to assemble the polyproline II binding epitope recognized by SH3 domains.

    abstract：:SH3 domains are molecular-recognition modules that function by interacting with proteins containing sequences in polyproline II (PPII) conformation. The main limitation in designing short-ligand peptides to interact with these domains is the preservation of this helical arrangement, for which a high content of proline...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章

    doi：10.1016/j.jmb.2004.06.078

    authors： Cobos ES,Pisabarro MT,Vega MC,Lacroix E,Serrano L,Ruiz-Sanz J,Martinez JC

    更新日期：2004-09-03 00:00:00

  • Discovery and Function of B-Cell IgD Low (BDL) B Cells in Immune Tolerance.

    abstract：:It is now appreciated that in addition to their role in humoral immunity, B cells also exert regulatory mechanisms that lead to attenuation of inflammatory responses. The concept of B-cell regulation became well recognized when mice deficient in B cells due to genetic disruption were shown to be refractory to recovery...

    journal_title：Journal of molecular biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jmb.2020.06.023

    authors： Khalil MI,Gurski CJ,Dittel LJ,Neu SD,Dittel BN

    更新日期：2021-01-08 00:00:00