Mechanistic modelling of genetic and epigenetic events in radiation carcinogenesis.

Abstract:

:Methodological problems arise on the way of radiation carcinogenesis modelling with the incorporation of radiobiological and cancer biology mechanistic data. The results of biophysical modelling of different endpoints [DNA DSB induction, repair, chromosome aberrations (CA) and cell proliferation] are presented and applied to the analysis of RBE-LET relationships for radiation-induced neoplastic transformation (RINT) of C3H/10T1/2 cells in culture. Predicted values for some endpoints correlate well with the data. It is concluded that slowly repaired DSB clusters, as well as some kind of CA, may be initiating events for RINT. As an alternative interpretation, it is possible that DNA damage can induce RINT indirectly via epigenetic process. A hypothetical epigenetic pathway for RINT is discussed.

journal_name

Radiat Prot Dosimetry

authors

Andreev SG,Eidelman YA,Salnikov IV,Khvostunov IK

doi

10.1093/rpd/ncl463

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

335-9

issue

1-4

eissn

0144-8420

issn

1742-3406

pii

ncl463

journal_volume

122

pub_type

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