A role for Phospholipase D in Drosophila embryonic cellularization.

abstract：BACKGROUND:Formation of haploid spermatozoa capable of fertilization requires proper programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA methyltransferase activity, contributes to DNA methylation pattern acquisition during gametogenesis remains unclear...

journal_title：BMC developmental biology

authors： La Salle S,Oakes CC,Neaga OR,Bourc'his D,Bestor TH,Trasler JM

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously reported human pancreas organoid (hPO) cultures do not expand efficiently long-term in a chemic...

journal_title：BMC developmental biology

authors： Georgakopoulos N,Prior N,Angres B,Mastrogiovanni G,Cagan A,Harrison D,Hindley CJ,Arnes-Benito R,Liau SS,Curd A,Ivory N,Simons BD,Martincorena I,Wurst H,Saeb-Parsy K,Huch M

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear. RESULTS:To help determine the function of ERK5 we have used gene targeting to inactivate this gene in mice. Here we report that ERK5 ...

journal_title：BMC developmental biology

authors： Yan L,Carr J,Ashby PR,Murry-Tait V,Thompson C,Arthur JS

更新日期：2003-12-16 00:00:00

abstract：BACKGROUND:The embryonic day E10-13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulin-like growth...

journal_title：BMC developmental biology

authors： Wang K,Shen H,Gan P,Cavallero S,Kumar SR,Lien CL,Sucov HM

更新日期：2019-03-25 00:00:00

abstract：BACKGROUND:Real-time quantitative PCR is a sensitive and very efficient technique to examine gene transcription patterns in preimplantation embryos, in order to gain information about embryo development and to optimize assisted reproductive technologies. Critical to the successful application of real-time PCR is carefu...

journal_title：BMC developmental biology

authors： Goossens K,Van Poucke M,Van Soom A,Vandesompele J,Van Zeveren A,Peelman LJ

更新日期：2005-12-03 00:00:00

abstract：BACKGROUND:The purpose of the study was an evaluation of fetal hip joint morphology during the second and the third trimester of pregnancy. Serial sections were performed on 23 cadaver infants. RESULTS:The mean lunar age was 6.6 months. Femoral shaft length (FSL) and width of the proximal and distal epiphysis were x-r...

journal_title：BMC developmental biology

authors： Masłoń A,Sibiński M,Topol M,Krajewski K,Grzegorzewski A

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, round and large. Scanning whole mount mammalian embryos with 3D-SIM is prone to failure due to the mov...

journal_title：BMC developmental biology

authors： Popken J,Dahlhoff M,Guengoer T,Wolf E,Zakhartchenko V

更新日期：2015-11-26 00:00:00

abstract：BACKGROUND:Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the bl...

journal_title：BMC developmental biology

authors： Zolini AM,Negrón-Pérez VM,Hansen PJ

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:Formation of branching tubes is a fundamental step in the development of glandular organs. To identify extracellular cues that orchestrate epithelial tubulogenesis, we employed an in vitro assay in which EpH4-J3B1A mammary epithelial cells form spheroidal cysts when grown in collagen gels under serum-free co...

journal_title：BMC developmental biology

authors： Montesano R,Carrozzino F,Soulié P

更新日期：2007-02-08 00:00:00

abstract：BACKGROUND:The miniature pig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resembles that of humans. However, little information is available on the process of tooth development or the exact molecular mechanisms controlling tooth development in miniatur...

journal_title：BMC developmental biology

authors： Song T,Wu T,Wei F,Li A,Wang F,Xie Y,Liu D,Fan Z,Wang X,Cheng S,Zhang C,He J,Wang S

更新日期：2014-04-21 00:00:00

abstract：BACKGROUND:Despite the detailed knowledge obtained over the last decade on the molecular regulation of gastrulation in amniotes, the process of amnion development has been poorly described and illustrated in mice, and conflicting descriptions exist. Understanding the morphogenesis and development not only of the early ...

journal_title：BMC developmental biology

authors： Pereira PN,Dobreva MP,Graham L,Huylebroeck D,Lawson KA,Zwijsen AN

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Germline stem cells (GSCs) are present in the gonads of Drosophila females and males, and their proper maintenance, as well as their correct differentiation, is essential for fertility and fecundity. The molecular characterization of factors involved in maintenance and differentiation is a major goal both in...

journal_title：BMC developmental biology

authors： Cash AC,Andrews J

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:The contribution of cell proliferation to regeneration varies greatly between different metazoan models. Planarians rely on pluripotent neoblasts and amphibian limb regeneration depends upon formation of a proliferative blastema, while regeneration in Hydra can occur in the absence of cell proliferation. Rec...

journal_title：BMC developmental biology

authors： Passamaneck YJ,Martindale MQ

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:Postnatal growth in mouse is rapid, with total skeletal muscle mass increasing several-fold in the first few weeks. Muscle growth can be achieved by either an increase in muscle fibre number or an increase in the size of individual myofibres, or a combination of both. Where myofibre hypertrophy during growth...

journal_title：BMC developmental biology

authors： White RB,Biérinx AS,Gnocchi VF,Zammit PS

更新日期：2010-02-22 00:00:00

abstract：BACKGROUND:Bats comprise the second largest order of mammals. However, there are far fewer morphological studies of post-implantation embryonic development than early embryonic development in bats. RESULTS:We studied three species of bats (Miniopterus schreibersii fuliginosus, Hipposideros armiger and H. pratti), repr...

journal_title：BMC developmental biology

authors： Wang Z,Han N,Racey PA,Ru B,He G

更新日期：2010-01-21 00:00:00

abstract：BACKGROUND:Monocyte chemoattractant protein-1(MCP-1) is a chemokine secreted by Leydig cells and peritubular myoid cells in the rat testis. Its role in regulating the development of Leydig cells via autocrine and paracrine is still unclear. The objective of the current study was to investigate the effects of MCP-1 on L...

journal_title：BMC developmental biology

authors： Zhan X,Zhang J,Li S,Zhang X,Li L,Song T,Liu Q,Lu J,Xu Y,Ge RS

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:The central nervous tissue contains diverse subtypes of neurons with characteristic morphological and physiological features and different neurotransmitter phenotypes. The generation of neurons with defined neurotransmitter phenotypes seems to be governed by factors differently expressed along the anterior-p...

journal_title：BMC developmental biology

authors： Varga BV,Hádinger N,Gócza E,Dulberg V,Demeter K,Madarász E,Herberth B

更新日期：2008-09-22 00:00:00

abstract：BACKGROUND:Our current knowledge on tooth development derives primarily from studies in mice. Very little is known about gene expression and function during human odontogenesis. Sonic Hedgehog (SHH) signaling has been demonstrated to play crucial roles in the development of multiple organs in mice, including the tooth....

journal_title：BMC developmental biology

authors： Hu X,Zhang S,Chen G,Lin C,Huang Z,Chen Y,Zhang Y

更新日期：2013-04-08 00:00:00

abstract：BACKGROUND:Pbx genes encode TALE class homeodomain transcription factors that pattern the developing neural tube, pancreas, and blood. Within the hindbrain, Pbx cooperates with Hox proteins to regulate rhombomere segment identity. Pbx cooperates with Eng to regulate midbrain-hindbrain boundary maintenance, and with Myo...

journal_title：BMC developmental biology

authors： French CR,Erickson T,Callander D,Berry KM,Koss R,Hagey DW,Stout J,Wuennenberg-Stapleton K,Ngai J,Moens CB,Waskiewicz AJ

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:Interactions of cells with the extracellular matrix (ECM) are critical for the establishment and maintenance of stem cell self-renewal and differentiation. However, the ECM is a complex mixture of matrix molecules; little is known about the role of ECM components in human embryonic stem cell (hESC) different...

journal_title：BMC developmental biology

authors： Ma W,Tavakoli T,Derby E,Serebryakova Y,Rao MS,Mattson MP

更新日期：2008-09-22 00:00:00

abstract：BACKGROUND:Mammalian Ras genes regulate diverse cellular processes including proliferation and differentiation and are frequently mutated in human cancers. Tumor development in response to Ras activation varies between different tissues and the molecular basis for these variations are poorly understood. The murine lens...

journal_title：BMC developmental biology

authors： Burgess D,Zhang Y,Siefker E,Vaca R,Kuracha MR,Reneker L,Overbeek PA,Govindarajan V

更新日期：2010-01-27 00:00:00

abstract：BACKGROUND:During Drosophila oogenesis, the follicular epithelium differentiates into several morphologically distinct follicle-cell populations. Characteristic bioelectrical properties make this tissue a suitable model system for studying connections between electrochemical signals and the organisation of the cytoskel...

journal_title：BMC developmental biology

authors： Weiß I,Bohrmann J

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:The zinc finger transcription factor Egr-1 (Early growth response 1) is central to several growth factors and represents an important activator of target genes not only involved in physiological processes like embryogenesis and neonatal development, but also in a variety of pathophysiological processes, for ...

journal_title：BMC developmental biology

authors： Dussmann P,Pagel JI,Vogel S,Magnusson T,Zimmermann R,Wagner E,Schaper W,Ogris M,Deindl E

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:The regulation of proneural gene expression is an important aspect of neurogenesis. In the study of the Drosophila proneural genes, scute and atonal, several themes have emerged that contribute to our understanding of the mechanism of neurogenesis. First, spatial complexity in proneural expression results fr...

journal_title：BMC developmental biology

authors： Holohan EE,zur Lage PI,Jarman AP

更新日期：2006-11-09 00:00:00

abstract：BACKGROUND:Biological processes are regulated by complex interactions between transcription factors and signalling molecules, collectively described as Genetic Regulatory Networks (GRNs). The characterisation of these networks to reveal regulatory mechanisms is a long-term goal of many laboratories. However compiling, ...

journal_title：BMC developmental biology

authors： Bacha J,Brodie JS,Loose MW

更新日期：2009-06-06 00:00:00

abstract：BACKGROUND:The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that many signaling pathways, including Activin, Bmp, Fgf, sonic hedgehog, Insulin-like growth factor (IGF)...

journal_title：BMC developmental biology

authors： Hirose K,Shiomi T,Hozumi S,Kikuchi Y

更新日期：2014-12-06 00:00:00

abstract：:Notch signalling acts in virtually every tissue during the lifetime of metazoans. Recent studies have pointed to multiple roles for Notch in stem cells during quiescence, proliferation, temporal specification, and maintenance of the niche architecture. Skeletal muscle has served as an excellent paradigm to examine the...

journal_title：BMC developmental biology

authors： Mourikis P,Tajbakhsh S

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or function within the optic nerve. As a first step in understanding the role of HDACs in optic nerve, this s...

journal_title：BMC developmental biology

authors： Tiwari S,Dharmarajan S,Shivanna M,Otteson DC,Belecky-Adams TL

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Combining microarray results and biological pathway information will add insight into biological processes. Pathway information is widely available in databases through the internet. Mammalian muscle formation has been previously studied using microarray technology in pigs because these animals are an intere...

journal_title：BMC developmental biology

authors： Te Pas MF,Hulsegge I,Coster A,Pool MH,Heuven HH,Janss LL

更新日期：2007-06-13 00:00:00

abstract：BACKGROUND:The C. elegans gene folt-1 is an ortholog of the human reduced folate carrier gene. The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms. A knockout mutation of the gene, folt-1(ok1460), was shown to cause sterility, and here we investigate the sourc...

journal_title：BMC developmental biology

authors： Austin MU,Liau WS,Balamurugan K,Ashokkumar B,Said HM,LaMunyon CW

更新日期：2010-05-04 00:00:00