Synthetic antibodies as therapeutics.

abstract：INTRODUCTION:Realization that oxygen is one of the key regulators of development and differentiation has a profound significance on how current cell-based and tissue engineering applications using adipose-derived stem cells (ASCs) can be further improved. AREAS COVERED:The article provides an overview of mechanisms of...

journal_title：Expert opinion on biological therapy

authors： Zachar V,Duroux M,Emmersen J,Rasmussen JG,Pennisi CP,Yang S,Fink T

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Vulvar squamous cell carcinoma (VSCC) develops via two different pathways: TP53 mutations in a background of lichen sclerosus or a persistent infection with high-risk human papilloma virus (HPV). The latter group of tumor responds better to treatment than the non-virally induced VSCC. This may be explained...

journal_title：Expert opinion on biological therapy

authors： Abdulrahman Z,Kortekaas KE,De Vos Van Steenwijk PJ,Van Der Burg SH,Van Poelgeest MI

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The therapeutic uses of botulinum toxin have been expanding due to deeper knowledge of its molecular behaviour and different mechanisms of action. OBJECTIVE:To present suggested doses of Botox and Dysport for controlling the muscle hyperkinetic activity in facial palsy in the perioral area and to review oth...

journal_title：Expert opinion on biological therapy

authors： de Maio M

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Over the past decade, the cytolytic capabilities of oncolytic viruses (OVs), exploited to selectively eliminate neoplastic cells, have become secondary to their use to elicit a tumor-directed immune response. AREAS COVERED:Here, based on an NCBI-PubMed literature survey, we review the efforts undertaken t...

journal_title：Expert opinion on biological therapy

authors： de Gruijl TD,Janssen AB,van Beusechem VW

更新日期：2015-07-01 00:00:00

abstract：:Malaria remains an important public health problem throughout the tropical world causing immense human suffering and impeding economic development. Despite extensive research for > 100 years, options for preventing malaria remain limited to vector control and chemoprophylaxis. The complexity of the organism and its li...

journal_title：Expert opinion on biological therapy

authors： Wipasa J,Riley EM

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Type 1 diabetes (T1DM) is an immune-mediated disease induced by antigen-specific T cells infiltrating pancreatic beta cells leading to the progressive loss of endogenous insulin secretion. AREAS COVERED:The identification of specific components of the autoimmune response favoured the implementation of sev...

journal_title：Expert opinion on biological therapy

authors： Guglielmi C,Williams SR,Del Toro R,Pozzilli P

更新日期：2016-06-01 00:00:00

abstract：:Cervical cancer is the second most common neoplastic disease affecting women worldwide. Basic, clinical and epidemiological analyses indicate that expression of high-risk human papillomaviruses (HPVs) E6/E7 genes is the primary cause of cervical cancer and represent ideal targets for the application of therapeutic nuc...

journal_title：Expert opinion on biological therapy

authors： DiPaolo JA,Alvarez-Salas LM

更新日期：2004-08-01 00:00:00

abstract：:Introduction: Peptide molecules are being vastly investigated as an emerging class of therapeutic molecules in recent years. Currently, 60 peptides have been approved by the US Food and Drug Administration (FDA), and more would enter the market in near future. Peptides have already opened their ways into cosmeceutical...

journal_title：Expert opinion on biological therapy

authors： Negahdaripour M,Owji H,Eslami M,Zamani M,Vakili B,Sabetian S,Nezafat N,Ghasemi Y

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Knowledge of IFN-antiviral activity against HIV infection dates from the first years of the AIDS epidemic. Recombinant IFN had an inhibitory effect on HIV and was not toxic to peripheral blood mononuclear cells (PBMC), and this finding was the basis for the design of clinical trials that evaluated the pote...

journal_title：Expert opinion on biological therapy

authors： Rivero-Juárez A,Frias M,Rivero A

更新日期：2016-09-01 00:00:00

abstract：:Stem cell transplantation, a widely accepted therapeutic approach to diseases of modular organs such as the heart and the endocrine pancreas, remains a controversial option for the nervous system. However, historical advances in the 1990s on key aspects of neural plasticity and the appreciation of the selective vulner...

journal_title：Expert opinion on biological therapy

authors： Koliatsos VE,Xu L,Yan J

更新日期：2008-02-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:The use of biologics as immune modulators in several autoimmune diseases has provided new tools to the physician's therapeutic armamentiarium and has led to improved patients' outcomes and quality of life. By producing autoantibodies, B cells in systemic lupus erythematosus (SLE) are key players...

journal_title：Expert opinion on biological therapy

authors： La Cava A

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:Regulatory T cells (Tregs) have been characterised in different cancers. They accumulate in peripheral blood and tumour microenvironments where they suppress tumour-specific immune responses, enabling tumours to develop without challenge. This tumour immune evasion represents a major obstacle to successful...

journal_title：Expert opinion on biological therapy

authors： Chaudhary B,Abd Al Samid M,al-Ramadi BK,Elkord E

更新日期：2014-07-01 00:00:00

abstract：:In recent years there has been significant new interest in the development of transmucosal (mostly oral) pharmaceutical formulations for the delivery of therapeutic proteins. Emphasis has been given to the molecular design of new carriers for the delivery of insulin, calcitonin and various types of interferons for the...

journal_title：Expert opinion on biological therapy

authors： Peppas NA,Wood KM,Blanchette JO

更新日期：2004-06-01 00:00:00

abstract：INTRODUCTION:Based on the known relevance of IL-6 in juvenile idiopathic arthritis (JIA) pathophysiology, tocilizumab has been investigated and approved for use in the treatment of systemic and polyarticular JIA. Tocilizumab is a humanized monoclonal antibody that inhibits signaling through both membrane bound and solu...

journal_title：Expert opinion on biological therapy

authors： Turnier JL,Brunner HI

更新日期：2016-01-01 00:00:00

abstract：:Introduction: The expiry of patents for biologics has led to the introduction of biosimilars for the treatment of immune-mediated inflammatory diseases (IMIDs). These treatment alternatives may allow earlier and wider access to appropriate therapy for patients without increasing the economic burden on health-care syst...

journal_title：Expert opinion on biological therapy

authors： Edwards CJ,Hercogová J,Albrand H,Amiot A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Obesity has long been associated with psoriasis and it is considered to be an independent risk factor for chronic heart diseases in these patients. Recently, some of the biologic drugs used for psoriasis have been reported to cause increase in body weight. It is currently not clear if this increased body wei...

journal_title：Expert opinion on biological therapy

authors： Al-Mutairi N,Nour T

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Oral health is affected by its resident microorganisms. Three prominent oral disorders are dental caries, gingivitis and periodontitis, with the oral microbiota playing a key role in the initiation/progression of all three. Understanding the microbiota and the diseases they may cause is critical to the dev...

journal_title：Expert opinion on biological therapy

authors： Saha S,Tomaro-Duchesneau C,Tabrizian M,Prakash S

更新日期：2012-09-01 00:00:00

abstract：:Introduction: Rheumatic diseases are inflammatory diseases that damage target organs via multiple subsets of immune cells. Fractalkine (FKN) acts as chemoattractant as well as adhesion molecule. It contributes to the pathogenesis of rheumatoid arthritis (RA) and other rheumatic diseases through multiple mechanisms: th...

journal_title：Expert opinion on biological therapy

authors： Muraoka S,Nishio J,Kuboi Y,Imai T,Nanki T

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Brain-derived neurotrophic factor (BDNF) has been implicated in wide range of neurological diseases and injury. This neurotrophic factor is vital for neuronal health, survival, and synaptic connectivity. Many therapies focus on the restoration or enhancement of BDNF following injury or disease progression....

journal_title：Expert opinion on biological therapy

authors： Deng P,Anderson JD,Yu AS,Annett G,Fink KD,Nolta JA

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Biological therapies have revolutionized moderate-to-severe psoriasis treatment. Increased understanding of disease pathogenesis has yielded multiple therapeutic targets involving the IL-23/Th17 pathway, while current therapies continue to be monitored for long-term efficacy and safety. AREAS COVERED:This...

journal_title：Expert opinion on biological therapy

authors： Mansouri B,Patel M,Menter A

更新日期：2013-12-01 00:00:00

abstract：:ABSTRACT Background: Thymosin alpha-1 (Ta-1) suppresses HBV viral replication, while the evidence of combination effect with nucleoide is still limited. We aimed to investigate the efficacy and safety of combination therapy of Ta-1 with entecavir (ETV) in patients with compensated liver cirrhosis. RESEARCH DESIGN AND...

journal_title：Expert opinion on biological therapy

authors： Wu X,Shi Y,Zhou J,Sun Y,Piao H,Jiang W,Ma A,Chen Y,Xu M,Xie W,Cheng J,Xie S,Shang J,Cheng J,Xie Q,Ding H,Zhang X,Bai L,Zhang M,Wang B,Chen S,Ma H,Ou X,Jia J,You H

更新日期：2018-07-01 00:00:00

abstract：:Complete resection is mandatory in order to achieve a cure in patients with early-stage non-small cell lung cancer (NSCLC). However, despite complete resection, a substantial proportion of patients have disease recurrence, with distant metastases being the primary sites of failure. Recent trials have conclusively demo...

journal_title：Expert opinion on biological therapy

authors： Potti A,Ganti AK

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:IL-21, a recently described common gamma-chain cytokine, can induce the maturation and enhanced cytotoxicity of natural killer (NK) and CD8(+) T cells and proliferation of CD40-stimulated B cells. Exogenous IL-21 has antitumor effects in murine models via immunological mechanisms. In addition, IL-21 can also...

journal_title：Expert opinion on biological therapy

authors： Andorsky DJ,Timmerman JM

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Two humanized monoclonal antibodies, bapineuzumab and solanezumab, directed against the N terminus and mid-region of β-amyloid (Aβ), respectively, were recently tested in large, long-term Phase III trials in patients with mild-to-moderate Alzheimer's disease (AD). AREAS COVERED:This review discusses curre...

journal_title：Expert opinion on biological therapy

authors： Panza F,Solfrizzi V,Imbimbo BP,Logroscino G

更新日期：2014-10-01 00:00:00

abstract：:This review discusses the present outlook for new thrombocytopenia therapies that induce haematopoietic stem and progenitor cells to proliferate, differentiate and produce functional platelets. A brief overview of megakaryopoiesis and its regulation by thrombopoietin (TPO) is followed by a discussion of how early expe...

journal_title：Expert opinion on biological therapy

authors： Szilvassy SJ

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To study the effectiveness and safety of anti-CD20 B-cell antibody rituximab (RTX) in the treatment of ocular mucous membrane pemphigoid (MMP). METHODS:Retrospective analysis of six MMP patients receiving RTX with or without concomitant immunosuppression. RTX was administered as a high dose regimen (1000 mg/...

journal_title：Expert opinion on biological therapy

authors： Rübsam A,Stefaniak R,Worm M,Pleyer U

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Tuberculosis (TB), an infirmity that mainly affects the respiratory system, is the world's second deadliest infectious disease, with > 9 million new cases diagnosed in 2006. One-third of the world's population is now infected with the TB bacillus. According to the WHO, an estimated 1.7 million people died fr...

journal_title：Expert opinion on biological therapy

authors： Giri PK

更新日期：2008-11-01 00:00:00

abstract：:Recent mechanistic studies on the role of heat-shock proteins (HSPs) to induce innate and adaptive immune responses have resulted in conflicting reports. Whereas some groups reported that HSPs have direct immunological function, others emphasised the endotoxin contamination of HSP preparations and questioned the antig...

journal_title：Expert opinion on biological therapy

authors： Manjili MH,Wang XY,MacDonald IJ,Arnouk H,Yang GY,Pritchard MT,Subjeck JR

更新日期：2004-03-01 00:00:00

abstract：:Soft tissue sarcomas are a challenge for medical oncology and gene therapy. Protective and sensitising approaches that target normal and malignant tissue, respectively, both have their role for opening the therapeutic window. Recent data show that an intensive maintenance chemotherapy significantly reduces metastatic ...

journal_title：Expert opinion on biological therapy

authors： Fruehauf S,Veldwijk MR,Zeller WJ,Laufs S

更新日期：2003-12-01 00:00:00

abstract：:Neovascularisation is a promising alternative therapeutic approach to re-establish blood flow in ischaemic tissues of patients suffering from coronary artery or peripheral artery disease. Often, these patients are not suitable candidates for current revascularisation procedures such as coronary angioplasty or bypass s...

journal_title：Expert opinion on biological therapy

authors： Ennett AB,Mooney DJ

更新日期：2002-12-01 00:00:00