Synthetic antibodies as therapeutics.


:Synthetic antibody libraries, whose repertoires are designed, have advanced in the last decade to rival natural repertoire-based libraries. Many types of diversity design have been shown to generate highly functional libraries. Defined template and defined diversity in synthetic antibody libraries improve the process of discovering and optimizing new antibodies. Synthetic libraries with different diversity design have targeted different epitopes on antigens, including epitopes that are unlikely to be targeted by immunization and hybridoma. Cross-species binding antibodies are prime examples of products generated by synthetic antibody libraries, and they are becoming the tools of choice to validate the selection of targeted molecules in therapeutic development. Synthetic antibody libraries complement the existing natural repertoire-based antibody libraries and hybridoma approach to maximize the potentials of antibodies as therapeutics.


Expert Opin Biol Ther


Fuh G




Has Abstract


2007-01-01 00:00:00












  • Ultra-low dose rituximab for refractory pemghigus vulgaris: a pilot study.

    abstract::Background: Pemphigus vulgaris is an autoimmune blistering disease affecting the skin and mucous membranes. Current treatments for pemphigus vulgaris include anti-inflammatory and immunosuppressive agents. Rituximab, an anti-CD20 monoclonal antibody, has been shown to be effective for the treatment of pemphigus vulgar...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章


    authors: Russo I,Miotto S,Saponeri A,Alaibac M

    更新日期:2020-06-01 00:00:00

  • Gene therapy strategies to improve strength and quality of flexor tendon healing.

    abstract:INTRODUCTION:Rupture of the repair and adhesion around a tendon are two major problems after tendon surgery. Novel biological therapies which enhance healing and reduce adhesions are goals of many investigations. Gene therapy offers a new and promising approach to tackle these difficult problems. In the past decade, we...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Tang JB,Zhou YL,Wu YF,Liu PY,Wang XT

    更新日期:2016-01-01 00:00:00

  • Future of tissue engineering in rheumatic diseases.

    abstract::Chronic inflammation during rheumatoid arthritis and degenerative processes during osteoarthritis eventually result in joint destruction. Anti-inflammatory therapies facilitate the inhibition or delay of progressing joint cartilage and bone loss, but do not regenerate these tissues. Surgical procedures are quite unsat...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章


    authors: Ringe J,Häupl T,Sittinger M

    更新日期:2007-03-01 00:00:00

  • Insulin degludec + liraglutide: a complementary combination.

    abstract:INTRODUCTION:The treatment of patients with type 2 diabetes mellitus remains challenging, as it goes beyond adequate glycemic control, in particular addressing weight, blood pressure and other contributors to cardiovascular disease. In addition, the progressive nature of type 2 diabetes mellitus demands the intensifica...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Stinkens K,Peene B,Mathieu C

    更新日期:2016-09-01 00:00:00

  • Promise of gene therapy to treat sickle cell disease.

    abstract:INTRODUCTION:Sickle cell anemia (SCA) is a hereditary blood disease caused by a single-gene mutation that affects millions of individuals world-wide. In this review, we focus on techniques to treat SCA by ex vivo genetic manipulation of hematopoietic stem/progenitor cells (HSPC), emphasizing replacement gene therapy an...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Romero Z,DeWitt M,Walters MC

    更新日期:2018-11-01 00:00:00

  • Etanercept (Enbrel) in the treatment of juvenile idiopathic arthritis.

    abstract:INTRODUCTION:Juvenile idiopathic arthritis (JIA) is a relatively common multidimensional and heterogeneous chronic disease of childhood. Children with JIA are at risk for significant morbidity in terms of joint damage, impairments in physical function and health-related quality of life. Outcomes for children with JIA h...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Berard RA,Laxer RM

    更新日期:2013-11-01 00:00:00

  • Therapeutic uses of botulinum toxin: from facial palsy to autonomic disorders.

    abstract:BACKGROUND:The therapeutic uses of botulinum toxin have been expanding due to deeper knowledge of its molecular behaviour and different mechanisms of action. OBJECTIVE:To present suggested doses of Botox and Dysport for controlling the muscle hyperkinetic activity in facial palsy in the perioral area and to review oth...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: de Maio M

    更新日期:2008-06-01 00:00:00

  • Peptide-based vaccination for colorectal cancer.

    abstract::Recently, the number of patients with colorectal cancer has been increasing. Although most patients with early colorectal cancer have a good prognosis, in the case of recurrent or metastatic disease, the prognosis is poor and most patients will ultimately die of cancer. Furthermore, the conventional treatment, such as...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Tsuruma T,Hata F,Furuhata T,Ohmura T,Katsuramaki T,Yamaguchi K,Kimura Y,Torigoe T,Sato N,Hirata K

    更新日期:2005-06-01 00:00:00

  • Hypoxia and adipose-derived stem cell-based tissue regeneration and engineering.

    abstract:INTRODUCTION:Realization that oxygen is one of the key regulators of development and differentiation has a profound significance on how current cell-based and tissue engineering applications using adipose-derived stem cells (ASCs) can be further improved. AREAS COVERED:The article provides an overview of mechanisms of...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Zachar V,Duroux M,Emmersen J,Rasmussen JG,Pennisi CP,Yang S,Fink T

    更新日期:2011-06-01 00:00:00

  • Injectable biomaterials for stem cell delivery and tissue regeneration.

    abstract:INTRODUCTION:Organ dysfunction and failure are major health issues affecting millions of patients, many of whom are desperate for organ transplantation. Tissue regeneration aims at providing alternative solutions through innovative application of cell biology and materials engineering to clinical practice. Biomaterials...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Zhang Z

    更新日期:2017-01-01 00:00:00

  • Activation of antigen-presenting cells by DNA delivery vectors.

    abstract::Gene-based modulation of immune functions is a promising means of eliciting protective immunity and induction of tolerance. Novel viral and non-viral DNA delivery systems are being investigated to achieve efficient gene transfer into mammalian cells. Antigen-presenting cells (APCs), in particular dendritic cells, are ...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Meng WS,Butterfield LH

    更新日期:2005-08-01 00:00:00

  • Head and neck cancer: gene therapy approaches. Part II: genes delivered.

    abstract::In Part I, the review summarised the safety of adenoviral vectors and provided insight into approaches being undertaken to improve the specificity, durability and potency of adenoviral delivery vehicles. In Part II, brief discussions are held regarding results of preclinical and clinical trials with a variety of diffe...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Nemunaitis J,O'Brien J

    更新日期:2002-03-01 00:00:00

  • Clinical applications of virosomes in cancer immunotherapy.

    abstract::Cancer immunotherapy is increasingly accepted as a treatment option for advanced stage disease. The identification of tumour-associated antigens in 1991 has prompted the development of antigen-specific immunotherapeutic strategies for a variety of cancers. Many of them result in some immunological responses in cancer ...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Adamina M,Guller U,Bracci L,Heberer M,Spagnoli GC,Schumacher R

    更新日期:2006-11-01 00:00:00

  • Melanocyte stem cells as potential therapeutics in skin disorders.

    abstract:INTRODUCTION:Melanocytes produce pigment granules that color both skin and hair. In the hair follicles melanocytes are derived from stem cells (MelSCs) that are present in hair bulges or sub-bulge regions and function as melanocyte reservoirs. Quiescence, maintenance, activation and proliferation of MelSCs are controll...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Lee JH,Fisher DE

    更新日期:2014-11-01 00:00:00

  • Vaccines in the management of hypertension.

    abstract:IMPORTANCE OF THE FIELD:In the USA only 35% of patients with hypertension achieve adequate blood pressure control. Non-compliance is one of the main barriers to treatment. Vaccine against hypertension is an innovative treatment, injected every 4 - 6 months, to combat non-compliance. AREAS COVERED IN THIS REVIEW:Pathog...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Do TH,Chen Y,Nguyen VT,Phisitkul S

    更新日期:2010-07-01 00:00:00

  • Interleukin-2 receptor blockade with humanized monoclonal antibody for solid organ transplantation.

    abstract:IMPORTANCE OF THE FIELD:Induction therapy has reduced the incidence of acute rejection compared with historical standards. The potency of currently available induction immunosuppression is not without risk and should be carefully considered. Induction with daclizumab, an IL-2 receptor antagonist, has been used safely a...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Campara M,Tzvetanov IG,Oberholzer J

    更新日期:2010-06-01 00:00:00

  • Rationale for and clinical development of anti-fractalkine antibody in rheumatic diseases.

    abstract::Introduction: Rheumatic diseases are inflammatory diseases that damage target organs via multiple subsets of immune cells. Fractalkine (FKN) acts as chemoattractant as well as adhesion molecule. It contributes to the pathogenesis of rheumatoid arthritis (RA) and other rheumatic diseases through multiple mechanisms: th...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章


    authors: Muraoka S,Nishio J,Kuboi Y,Imai T,Nanki T

    更新日期:2020-11-01 00:00:00

  • Atoh1 gene therapy in the cochlea for hair cell regeneration.

    abstract:INTRODUCTION:The sensory epithelium of the cochlea is a complex structure containing hair cells, supporting cells and auditory nerve endings, all of which degenerate after hearing loss in mammals. Biological approaches are being considered to preserve and restore the sensory epithelium after hearing loss. Of particular...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Richardson RT,Atkinson PJ

    更新日期:2015-03-01 00:00:00

  • Generation and genetic modification of induced pluripotent stem cells.

    abstract:IMPORTANCE OF THE FIELD:The generation of induced pluripotent stem cells (iPSCs) enabled by exogenous expression of the canonical Oct4, Sox2, Klf4 and c-Myc reprogramming factors has opened new ways to create patient- or disease-specific pluripotent cells. iPSCs represent an almost inexhaustible source of cells for tar...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Schambach A,Cantz T,Baum C,Cathomen T

    更新日期:2010-07-01 00:00:00

  • Biologicals and biosimilars: safety issues in Europe.

    abstract:INTRODUCTION:Medicinal products of a biological origin are approved by the EMA at a centralized level. However, there is no harmonization about their use in Europe. The current regulation referring to the safety of biological medicinal products and biosimilars in Europe has been identified. The safety associated with m...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Portela MDCC,Sinogas C,Albuquerque de Almeida F,Baptista-Leite R,Castro-Caldas A

    更新日期:2017-07-01 00:00:00

  • Ranibizumab and aflibercept for the treatment of wet age-related macular degeneration.

    abstract:INTRODUCTION:Wet age-related macular degeneration (AMD) is a potentially blinding eye disease that causes vision loss among individuals > 50 years old. The main goal in the treatment of wet AMD is to inhibit the choroidal neovascularization (CNV). Currently, ranibizumab and aflibercept are two available anti-VEGF drug ...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Yazdi MH,Faramarzi MA,Nikfar S,Falavarjani KG,Abdollahi M

    更新日期:2015-01-01 00:00:00

  • A comparison of human natural monoclonal antibodies and aptamer conjugates for promotion of CNS remyelination: where are we now and what comes next?

    abstract:INTRODUCTION:Multiple sclerosis (MS) is a chronic and progressive inflammatory demyelinating disease of the human central nervous system (CNS) and is the most common disabling neurological condition in young adults, resulting in severe neurological defects. No curative or long-term progression-inhibiting therapy has ye...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Perwein MK,Smestad JA,Warrington AE,Heider RM,Kaczor MW,Maher LJ 3rd,Wootla B,Kunbaz A,Rodriguez M

    更新日期:2018-05-01 00:00:00

  • T regulatory cells as an immunotherapy for transplantation.

    abstract::Advances in immunosuppressive therapies have made tissue and organ transplantation a common procedure in clinical medicine. However, true donor and recipient tolerance is not regularly achieved and almost all transplant recipients continue to require immunosuppressants throughout life, which is associated with side ef...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Albert MH,Anasetti C,Yu XZ

    更新日期:2006-04-01 00:00:00

  • Fighting infection using immunomodulatory agents.

    abstract::The last decade has seen the emergence of immunomodulators as promising therapeutic agents in infectious diseases. A diverse array of recombinant, synthetic and natural immunomodulatory preparations for prophylaxis and treatment of various infections are available today. Some of these substances, such as granulocyte c...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Masihi KN

    更新日期:2001-07-01 00:00:00

  • Progress of dendritic cell-based cancer vaccines for patients with hematological malignancies.

    abstract:INTRODUCTION:Dendritic cells (DCs) are the most professional antigen-presenting cells eliciting cellular and humoral immune responses against cancer cells by expressing these antigens on MHC class I/II complexes to T cells. Therefore, they have been employed in many clinical trials as cancer vaccines for patients with ...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Ni M,Hoffmann JM,Schmitt M,Schmitt A

    更新日期:2016-09-01 00:00:00

  • Myoblast transplantation for inherited myopathies: a clinical approach.

    abstract::Myoblast transplantation (MT) is an experimental strategy for the potential treatment of myopathies. MT has two properties that make it potentially beneficial: genetic complementation and myogenic potential. Preclinical experiments on monkeys have shown that promising results can be obtained with MT in large muscles o...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Skuk D

    更新日期:2004-12-01 00:00:00

  • A critical review on a globally-licensed, live, orally-administrable, monovalent human rotavirus vaccine: Rotarix.

    abstract::Rotavirus is the major cause of severe gastroenteritis in children worldwide, and two, live, orally-administrable vaccines are licensed globally. They are Rotarix, a monovalent, human rotavirus-based vaccine (GlaxoSmithKline), and RotaTeq, a pentavalent, bovine-human reassortant vaccine (Merck). The RIX4414 strain, a ...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Nakagomi T,Nakagomi O

    更新日期:2009-08-01 00:00:00

  • Regeneration of teeth using stem cell-based tissue engineering.

    abstract::Tooth autotransplantation, allotransplantation and dental implants have existed for many years, but have never been totally satisfactory. Thus, the development of new methods of tooth replacement has become desirable, and with the increasing knowledge of stem cell biology becomes a realistic possibility. Stem cell-bas...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Yen AH,Sharpe PT

    更新日期:2006-01-01 00:00:00

  • Biosimilars for breast cancer.

    abstract::Introduction: Cancer treatment has evolved significantly with the introduction of biologic agents, especially in the breast cancer (BC) area. The use of trastuzumab for HER2 amplified BCsignificantly improves survival in both metastatic and early stage disease. Although the efficacy of biologics is undeniable, their h...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章,评审


    authors: Migliavacca Zucchetti B,Nicolò E,Curigliano G

    更新日期:2019-10-01 00:00:00

  • Adalimumab in the treatment of rheumatoid arthritis.

    abstract::Adalimumab (ADA), a fully human monoclonal antibody against TNF-α is indicated for the treatment of rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, Crohn's disease, ulcerative colitis and psoriasis. In RA, it may be prescribed in combination with methotrexate or o...

    journal_title:Expert opinion on biological therapy

    pub_type: 杂志文章


    authors: Voulgari PV,Kaltsonoudis E,Papagoras C,Drosos AA

    更新日期:2012-12-01 00:00:00