Abstract：
:Catastrophic antiphospholipid syndrome (CAPS) (Asherson's Syndrome), is a life-threatening condition characterized by a rapidly progressive thromboses resulting in a multiorgan dysfunction syndrome (MODS), evidence of systemic inflammatory response syndrome (SIRS) in the presence of antiphospholipid antibodies. CAPS differs from the classic APS by predominantly affecting small vessels, involvement of unusual organs, rapid onset of MODS, and the development of acute respiratory distress syndrome (ARDS) in 25% of patients, which is a feature of SIRS. Obstetric-related multiorgan failure may be a feature of a subset of CAPS more frequently than was previously thought. Patients with obstetric complications should be tested for antiphospholipid antibodies and genetic thrombophilia in order to institute early prophylaxis. Low-molecular-weight heparin is the drug of choice for preventing obstetric complications and CAPS due to its anticoagulant and anti-inflammatory properties.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Makatsariya A,Asherson RA,Bitsadze V,Baimuradova S,Akinshina Sdoi
10.1016/j.autrev.2006.06.011subject
Has Abstractpub_date
2006-12-01 00:00:00pages
89-93issue
2eissn
1568-9972issn
1873-0183pii
S1568-9972(06)00095-4journal_volume
6pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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