Abstract:
:We conducted a retrospective single-center study to describe the clinical features of sinonasal sarcoidosis (SNS) and to determine whether SNS is associated with a particular clinical phenotype of sarcoidosis. Twenty patients with histologically proven SNS (men/women, 7/13; mean age, 32 +/- 9 yr) were compared with control patients with sarcoid but without sinonasal (SN) involvement. Each patient was matched with 2 controls for the date of admittance in our institution. SN involvement occurred in the course of previously known sarcoidosis in 8 patients, whereas it preceded disease diagnosis in 12 patients. Among these 12 patients, 4 initially presented with strictly isolated SNS and 8 had other associated signs related to sarcoidosis. The most common symptoms were stuffiness (90%), anosmia (70%), and rhinorrhea (70%). Lupus pernio was frequent (50%). Local examination was constantly abnormal and showed hypertrophy (75%) and purplish coloring of the nasal mucosa with granulations (50%) on the septum and/or inferior turbinates. Computed tomography scans showed medial lytic lesions, mainly of the septum and/or the turbinates in about half the cases. All patients had negative antineutrophil cytoplasmic antibodies. Patients with SNS had significantly more frequent and severe involvement of vital organs than controls, had a longer history of sarcoidosis, and required systemic treatment more frequently (100% vs. 57.7%, p < 0.001) and for a longer time (78 +/- 42 mo vs. 29 +/- 18 mo, p < 0.0001). Corticosteroids maintenance dosage was high (10.5 +/- 6 mg daily) and mainly depended on SN involvement. Although rare, SN involvement is a severe and recalcitrant manifestation of sarcoidosis representing a therapeutic challenge.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Aubart FC,Ouayoun M,Brauner M,Attali P,Kambouchner M,Valeyre D,Nunes Hdoi
10.1097/01.md.0000236955.79966.07subject
Has Abstractpub_date
2006-11-01 00:00:00pages
365-371issue
6eissn
0025-7974issn
1536-5964pii
00005792-200611000-00003journal_volume
85pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:To comprehensively evaluate the treatment efficacy and safety of silymarin for patients with glucose/lipid metabolic dysfunction using a meta-analysis. METHODS:A systematic literature search in PubMed, EMBASE and Cochrane Library databases was performed up to October 1, 2019. STATA 13.0 software was used to...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022249
更新日期:2020-10-02 00:00:00
abstract:OF BACKGROUND DATA:There is growing interest in identifying nutritional biomarkers associated with poor outcomes of elective spine surgery. Prealbumin and transferrin are both biomarkers of nutritional status that can be obtained from clinical laboratories. However, associations of preoperative measures of these nutrit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014741
更新日期:2019-03-01 00:00:00
abstract::Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) is rare and associated with a suboptimal prognosis. The aim of this retrospective study was to identify prognostic factors, with a particular focus on the dynamics of serum AFP levels during treatment, in AFPGC patients.Data of patients with pathologically diagn...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000023326
更新日期:2020-11-20 00:00:00
abstract::Purulent pericarditis, a localized infection within the pericardial space, has become a rare entity in the modern antibiotic era. Although historically a disease of children and young adults, this is no longer the case: the median age at the time of diagnosis has increased by nearly 30 years over the past 6 decades. D...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0b013e318194432b
更新日期:2009-01-01 00:00:00
abstract::Many studies have been reported that platelet-lymphocyte ratio (PLR) may be associated with the prognosis of colorectal cancer (CRC), but the results are inconsistent. Current opinion on the prognostic role of the PLR in CRC is inconsistent and inconclusive. Therefore, we conduct a meta-analysis that combines these st...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000003837
更新日期:2016-06-01 00:00:00
abstract::Hip preserving procedures are still a challenge in late-stage osteonecrosis of femoral head (ONFH) patients. We aimed to compare the clinical outcomes of surgical dislocation and impaction bone graft and surgical dislocation and rotational osteotomy for treatment of ONFH in Association Research Circulation Osseous (AR...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020215
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:Although there are various therapeutic methods for the treatment of knee osteoarthritis, each has its advantages and shortcomings, and a definitive treatment method is yet to be determined. This pilot study is designed to obtain basic data for a further large-scale trial as well as provide information abou...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000021957
更新日期:2020-09-04 00:00:00
abstract:INTRODUCTION:Mycoplasma pneumoniae (MP) infection in infants is usually overlooked and it might result in important complications if left untreated. MP-induced arthritis is probably the least common extrapulmonary manifestation and frequently leads to delays in the diagnosis. PATIENT CONCERNS:We report the case of a 2...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000024316
更新日期:2021-01-15 00:00:00
abstract::Routine postoperative surveillance is recommended for the patients with colorectal cancer (CRC). This study aimed to clarify the conditions indicate initial suspicion of CRC recurrence in different preoperative serum carcinoembryonic antigen (CEA) level groups, including positive physical signs/symptoms, elevated CEA ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022803
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND:Recently, many studies have been conducted to investigate the relationship between the A46G polymorphism in the β2-adrenergic receptor (ADRB2) gene and essential hypertension risk in the Chinese population. However, the results of previous studies were conflicting. OBJECTIVES:The present study aimed to inve...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023164
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:The blood glucose response to moderate-intensity exercise remains unclear for patients with type 2 diabetes (T2DM). In addition, little is known about determinants of blood glucose response to a 12-week moderate-intensity exercise training. Therefore, this study aimed to explore trends in blood glucose in re...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000016860
更新日期:2019-09-01 00:00:00
abstract::Nocturnal variations in blood pressure (BP) were associated with carotid intima-media thickness. However, the precise relationship between circadian variations of BP and carotid plaques remains unknown. Therefore, the prognostic value of reverse-dipper pattern of BP for carotid plaque was investigated. In this cross-s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000604
更新日期:2015-03-01 00:00:00
abstract::This study aimed to investigate the application of the healthcare failure mode and effect analysis (HFMEA) to reduce the incidence of posture syndrome of thyroid surgery (PSTS).Subjects before (n = 78, July 2017-December 2017) and after (n = 114, January 2018-June 2018) HFMEA implementation (The Second Hospital of Nan...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018309
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The Pharmaceutical industry sponsorship, research outcome and quality has been already evaluated for clinical trials in order to analyze if this kind of sponsorship affects the results of clinical trials. In this sense, this study has the aim to investigate whether placebo use allows positive outcomes regard...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022915
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Diabetic macular edema (DME) can cause severe vision impairments for patients with diabetes. Recently, Conbercept has shown efficacy on DME with 3-monthly loading dose injection and pro re nata (PRN, 3+PRN) thereafter in retrospectivetrials. Furthermore, there are some other approaches have been recommended ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021992
更新日期:2020-08-28 00:00:00
abstract:RATIONALE:Patients of critical pulmonary artery stenosis would face severe hypoxemia, cardiac failure as well as massive hemorrhage during percutaneous balloon dilation and pulmonary arterial stent implantation. Here, we present a case in which the elective use of extracorporeal membrane oxygenation (ECMO) support succ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015754
更新日期:2019-05-01 00:00:00
abstract::Although obesity is clearly identified as a risk factor for hypertension, the association between its different metabolic phenotypes and hypertension remains unclear. We aimed to investigate this association and compare the degree of association between metabolic health and obesity phenotypes defined by 5 representati...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012425
更新日期:2018-09-01 00:00:00
abstract::To compare the epidemiological and psychological features of globus symptoms between individuals from urban and rural areas in Guangzhou.In total, 3360 individuals aged 18 years and over were selected to participate in our questionnaire investigation using random cluster sampling under the stratification of a urban ar...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012986
更新日期:2018-10-01 00:00:00
abstract:RATIONALE:Sodium valproate (VPA) and lamotrigine (LTG) are widely used antiepileptic drugs, disabling postural, and action tremors after using LTG with VPA were reported in 1993. However, in this study, we describe a patient in whom disabling resting-type tremor induced by 2-year use of VPA and LTG. PATIENT CONCERNS:A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008711
更新日期:2017-11-01 00:00:00
abstract:RATIONALE:Primary hepatic lymphoma (PHL) is an extremely rare manifestation of extranodal non-Hodgkin lymphoma. There were few cases about PHL in recent years, while cases using positron emission tomography (PET) modalities for both diagnosis and follow-up were even rare. PATIENT CONCERNS:A 29-year-old man complaining...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018980
更新日期:2020-01-01 00:00:00
abstract::Aortoiliac occlusive disease (AIOD) affects the systemic vascular resistance and increases the afterload because the left ventricle (LV) must work harder to eject blood into a smaller vascular bed. This study was to determine whether successful revascularization of AIOD is associated with improvement of left ventricul...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012339
更新日期:2018-09-01 00:00:00
abstract:RATIONALE:Repair of soft tissue defects on the dorsum of the hand with accompanying tendon defects is a challenging problem in clinical practice. PATIENT CONCERNS:Here, we describe the case of a 3-year-old boy with a 1-week old soft tissue injury with infection due to a soft tissue defect on the dorsum of his right ha...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021837
更新日期:2020-08-21 00:00:00
abstract::Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result from mass effect, nerve compression, or vascular compromise. The differential diagnosis of HP includes immune-mediated conditions such as rheumatoid arthriti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e31829cce35
更新日期:2013-07-01 00:00:00
abstract::Abnormalities in the parathyroid hormone (PTH) gene as a cause of hypoparathyroidism were evaluated by linkage analysis with DNA polymorphisms adjacent to the PTH gene in 8 families in which members were affected with familial isolated hypoparathyroidism (FIH). We found that in none of the 23 affected individuals was ...
journal_title:Medicine
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract::Chronic hepatitis B (CHB) remains a global health problem. Therapeutic vaccination has been successfully employed to treat a subpopulation of CHB patients. Personalized treatment can not only improve therapeutic efficacy, but also decrease the cost of medical care. Since microRNAs (miRNAs) are highly conserved and are...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000002511
更新日期:2016-01-01 00:00:00
abstract::Myositis-specific autoantibodies, such as anti-melanoma differentiation associated gene 5 (MDA5) and anti-anti-amino acyl-tRNA synthetases (ARS) antibodies, are associated with interstitial lung diseases (ILD), which determine the prognosis of polymyositis/dermatomyositis (PM/DM) patients. However, there is a paucity ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015578
更新日期:2019-05-01 00:00:00
abstract::To compare imaging indicators and clinical effects of extreme lateral interbody fusion (XLIF) using allogenic bone, autologous bone marrow + allogenic bone, and rhBMP-2 + allogenic bone as bone graft materials in the treatment of degenerative lumbar diseases.This was a retrospective study of 93 patients with lumbar in...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017685
更新日期:2019-11-01 00:00:00
abstract::In this study, balance performance, agility, eye-hand coordination, and sports performance were compared between amateur badminton players and active controls.Thirty young adult badminton players and 33 active controls participated in the study. Static single-leg standing balance (with eyes closed) was measured using ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014134
更新日期:2019-01-01 00:00:00
abstract::Primary hepatic neuroendocrine tumors (PHNETs) are very rare and their clinical features and treatment outcomes are not well understood. It is difficult to reach a proper diagnosis before biopsy or resection. The aim of this study was to analyze the imaging features of PHNETs on contrast-enhanced ultrasound (CEUS). Th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003450
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:This study aimed to investigate the safety and efficacy of the cystotome-assisted prechop phacoemulsification surgery (CAPPS) and conventional phacoemulsification surgery (CPS) in patients with IV degree nucleus cataract. METHODS:The prospective, randomized, consecutive, comparative cohort study consecutive...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000013124
更新日期:2018-11-01 00:00:00