Abstract:
BACKGROUND:Charcot arthropathy is a chronic, progressive destructive process affecting bone architecture and joint alignment in people lacking protective sensation. The etiologic factors leading to progressive bone resorption have not been elucidated. The purpose of this study was to histologically examine surgical specimens with Charcot arthropathy for cell type and immunoreactivity of known cytokine mediators of bone resorption. METHODS:Tissue samples of 20 specimens with known Charcot arthropathy were stained for Hematoxylin and Eosin (H&E) to quantify cell type. Nine of the specimens were stained with interleukin-1 (IL-1) antibody, nine with tumor necrosis factor (TNF) alpha antibody, and nine with interleukin-6 (IL-6) antibody. Distribution of staining was graded as focal (less than 10% of cells), moderate (10% to 50% of cells), and diffuse (more than 50% of cells) by two independent investigators. Inflammatory cells in tissue sections of rheumatoid synovium served as a positive control. RESULTS:Osteoclasts were seen in excessive numbers lining the resorptive bone lacunae. There was a disproportionate increase in osteoclasts to osteoblasts in the Charcot-reactive bone. In each case, osteoclasts demonstrated immunoreactivity for IL-1, IL-6 and TNF-alpha with a grade of moderate or diffuse reactivity. CONCLUSION:The findings of excessive osteoclastic activity in the environment of cytokine mediators of bone resorption (IL-1, IL-6, and TNF-alpha) suggest enhanced bone resorption through the stimulation of osteoclastic progenitor cells as well as mature osteoclasts. Alteration in the synthesis, secretion, or activity of these important regulatory molecules through the use of pharmacologic agents may, in turn, alter bone remodeling and loss and lead to accelerated healing without collapse or malalignment.
journal_name
Foot Ankle Intjournal_title
Foot & ankle internationalauthors
Baumhauer JF,O'Keefe RJ,Schon LC,Pinzur MSdoi
10.1177/107110070602701007subject
Has Abstractpub_date
2006-10-01 00:00:00pages
797-800issue
10eissn
1071-1007issn
1944-7876pii
942122journal_volume
27pub_type
杂志文章abstract:BACKGROUND:Tibiotalocalcaneal (TTC) arthrodesis is a proven solution for severe hindfoot arthropathy that reestablishes stability for plantigrade gait and alleviates pain, while correcting deformity. Intramedullary nailing is an effective option for fixation. The aim of this study was to determine clinical outcome, ana...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100714565900
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Achilles tendon lengthening is an important part of the operative management of numerous foot and ankle disorders. The most commonly used percutaneous technique involves three hemitenotomies: medial, lateral, and medial. The discovery that Achilles tendon fibers may undergo external torsion created concern t...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070602701116
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:The surgical management of brachymetatarsia remains controversial, and choice is based on potential complications. We report a classification of complications based on severity, and we hypothesized that use of a semicircular external fixator would minimize severe complications in lateral metatarsal lengtheni...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100715593373
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:It is still unknown how ankle range of motion changes following total ankle arthroplasty. This study was undertaken to more accurately address patient expectations, guide postoperative rehabilitation, and improve our understanding of how ankle range of motion changes with time. METHODS:119 total ankle repla...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100713481433
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Suture anchors have been used for soft tissue repair in orthopedic surgery for decades. Recently, bioabsorbable suture anchors have increased in popularity and have spurred the introduction of ultrasound-assisted systems. The purpose of our study was to determine the clinical safety and efficacy of a new ult...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100720935122
更新日期:2020-09-01 00:00:00
abstract::The records of 104 patients who underwent reconstructive foot and ankle surgery for deformities secondary to rheumatoid arthritis were reviewed. The use of rheumatoid chemotherapeutic agents, age, sex, rheumatoid nodule status, and the number of concurrent surgical procedures performed was analyzed to determine any as...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070302400106
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:The proximal crescentic osteotomy is an effective technique for correcting a widened 1-2 intermetatarsal angle associated with moderate to severe hallux valgus deformities. However, postoperative dorsal malunion at the osteotomy site from loss of fixation has been reported. The purpose of this study was to e...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070502600505
更新日期:2005-05-01 00:00:00
abstract::Achilles tendinosis is a degenerative overuse tendinopathy involving the primary ankle plantarflexors, namely the soleus and gastrocnemius muscles forming the tendo Achilles. The Orthopaedic Research Institute-Ankle Strength Testing System (ORI-ASTS) was designed to record objective measurements of force generated wit...
journal_title:Foot & ankle international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/107110070202300206
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Wide variations in definitions of lesser toe deformities exist. In addition, a general consensus regarding treatment of lesser toe deformities is lacking. The objective of this study was to evaluate of the definitions, current concepts, and treatment protocols for lesser toe deformities among orthopaedic dep...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2007.1265
更新日期:2007-12-01 00:00:00
abstract::Three hundred and eleven patients have been enrolled in a multi-center prospective study evaluating the outcome of hallux valgus surgery by the members of the American Orthopaedic Foot and Ankle Society. One hundred seventy-nine of these patients have completed six-month follow-up questionnaires, and 195 have complete...
journal_title:Foot & ankle international
pub_type: 杂志文章,多中心研究
doi:10.1177/107110070102201205
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:The Self-reported Foot and Ankle Score (SEFAS) is a patient-reported outcome measure, while the American Orthopedic Foot and Ankle Society Score (AOFAS) is a clinician-based score, both used for evaluation of foot and ankle disorders. The purpose of this study was to compare the psychometric properties of th...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100714543647
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Previous studies that investigated mobilization with movement (MWM) treatment assessed only improvements in passive range of motion (ROM). No information is currently available regarding the efficacy of modified MWM by application of tape. Therefore, we investigated the effect of uphill walking with modified...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100714543797
更新日期:2014-11-01 00:00:00
abstract::A retrospective review was performed on industrial patients who sustained calcaneal fractures within the State of Idaho during the years 1992 to 1994, and these patients were insured by the Idaho State Insurance Fund. Of 48 calcaneal fractures that occurred during this period, 18 were non-displaced extra-articular fra...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070002101102
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Among the various operative treatments of Morton's neuroma, deep transverse metatarsal ligament (DTML) release has been performed for decompression of neuroma. However, the main lesion of Morton's neuroma is located between the metatarsal head and the metatarsophalangeal (MTP) joint and more distal than the ...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100713499905
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to review the results of arthrodesis of the Charcot hindfoot when an implantable bone growth stimulator was added to the procedure. Arthrodesis of the Charcot hindfoot has a high nonunion and complication rate. METHODS:Ten patients (ages 50 to 69 years) with Charcot neuroarthro...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2007.0971
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Computer Assisted Surgery (CAS) has shown the potential to increase the accuracy of surgical procedures in different fields of orthopedic surgery. The clinical experiences of 100 cases with CAS guided arthrodeses were evaluated. MATERIALS AND METHODS:Two navigation systems were used (VectorVision/Navivision...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2008.1235
更新日期:2008-12-01 00:00:00
abstract::The effect of a simulated leg length discrepancy on foot loading patterns and gait cycle times in normal individuals was investigated. Thirty feet of 15 normal volunteers were evaluated. Leg length discrepancy was simulated using flexible polyurethane soles. As leg length discrepancy increased, the total loading incre...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070302400310
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:There is limited consensus on the optimal operative technique for correcting heel varus in patients with Charcot-Marie-Tooth (CMT) disease. This comparative study evaluated the ability of 4 lateralizing calcaneal osteotomies, with and without Dwyer wedge resection and coronal rotation of the posterior tubero...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100718781572
更新日期:2018-10-01 00:00:00
abstract::Compartment syndrome of the newly discovered calcaneal compartment of the foot is a theoretical possibility following tibial fracture due to the communication with the deep posterior compartment of the calf. Forty-nine patients were reviewed at least 18 months after open or closed tibial shaft fractures treated with t...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070102200206
更新日期:2001-02-01 00:00:00
abstract::In 105 rabbits the course of healing was examined at one, two, four, eight and 12 weeks (21 rabbits per group) after an experimental Achilles tendon rupture. The following treatment modalities were compared: A) primary functional treatment; B) operative functional treatment (resorbable suture); and C) operative functi...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070202300704
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Research into gait characteristics has led to the creation of experimental gait simulators. The aim of this work was the development of a Contact Gait Simulation System (CGSS) to generate realistic plantar pressures for the contact phase of gait. The simulator seeks to create muscle loads which guide the foo...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2008.0066
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:A few studies report correlations between radiographic and anatomic measurements of the distal metatarsal articular angle (DMAA). However, little is known about how the DMAA correlates with the hallux valgus angle (HVA) and with anatomic and clinical radiographic measurements. METHODS:We dissected, measured...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100714522027
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Flexible suture-button devices are used to stabilize the distal tibiofibular joint after syndesmotic rupture, but little is known about how they affect fibular motion during cyclic physiological loading. This study examined how much fibular motion occurs during cyclic loading of ankles repaired with suture-b...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2009.0346
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Evans showed that lengthening the lateral column by inserting structural bone graft into the anterior calcaneus could correct abduction and valgus deformity in flatfoot. To better understand the mechanism of correction and the three-dimensional effect of this procedure a cadaver study was done. METHODS:Thre...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070502600209
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated higher infection rates following elective procedures on the foot and ankle compared with procedures involving other areas of the body. Previous studies also have documented the difficulty of eliminating bacteria from the forefoot prior to surgery. The purpose of the present...
journal_title:Foot & ankle international
pub_type: 杂志文章,随机对照试验
doi:10.3113/FAI.2009.0860
更新日期:2009-09-01 00:00:00
abstract::The American Orthopaedic Foot and Ankle Society "Diabetic Foot Care" patient education leaflet was revised to improve the layout and emphasis of key concepts of preventive care. This included review of daily foot and shoe examination, danger signs, daily washing and foot care, shoe fitting, medical care, and avoidance...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070502600110
更新日期:2005-01-01 00:00:00
abstract::The purpose of this study was to evaluate the biomechanical properties of commonly used autogenous transplants for the surgical stabilization of chronic lateral ankle instability. We dissected the transplants (peroneus longus, peroneus brevis, Achilles and plantaris tendon, periosteal flap, fascia, corium) and the ant...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070202300714
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:The distal attachment of the flexor hallucis longus (FHL) tendon with the flexor digitorum longus (FDL) tendon varies antomically. The presence of a strong link between the two tendons can preserve distal function if one of the tendons is used for transfer. METHODS:Twenty-four cadaver legs were dissected, a...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070602700708
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Insertional Achilles tendinopathy and retrocalcaneal bursitis is difficult to treat, and several operative techniques have been used after failure of conservative management. Dorsal wedge calcaneal osteotomy has been described for the treatment of insertional Achilles pathology. It was hypothesized that dors...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100716681139
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Extra-articular dorsal closing wedge osteotomy has been used with successful results for Freiberg disease; however, there has been concern regarding the technical difficulty. The purpose of this study was to address technical tips and report on the clinical and radiographic outcome using Kirchner wire-assist...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100712460185
更新日期:2013-01-01 00:00:00