Abstract:
:Leydig cells and seminiferous tubules of human testicular tissue were successfully separated by means of an anti-substance P-antiserum. On incubation with (14C)-testosterone or (14C)-dihydrotestosterone (DHT) it could be shown that besides DHT and 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol) also 5 alpha-androstane-3 beta, 17 beta-diol (3 beta-diol) originated in the tubular compartment. The ratio 3 alpha/3 beta-diol was found to be higher (0.7) here compared to incubation with whole testicular tissue (0.2), indicating that the testicular interstitium influences the metabolism of DHT by the seminiferous tubules.
journal_name
Andrologiajournal_title
Andrologiaauthors
Tamm J,Volkwein U,Schulze Wsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
80-4issue
1eissn
0303-4569issn
1439-0272journal_volume
22pub_type
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