Abstract：
:The insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes. This study assessed the relationships between circulating ACE activity, ACE I/D genotype, mechanical efficiency and the maximal rate of oxygen uptake in sedentary individuals. Sixty-two untrained women were tested for mechanical efficiency during submaximal cycle ergometry (delta and gross efficiencies during exercise between 40 and 80 W) and the maximal rate of oxygen uptake during incremental treadmill running. Respiratory variables were measured using indirect calorimetry. Venous blood was obtained for direct assay of circulating ACE activity, allowing for the assessment of correlations between two continuous variables, rather than a categorical analysis of endurance phenotype by genotype alone. ACE I/D genotype was also determined, and was strongly associated with circulating ACE activity (P < 0.0005). Neither circulating ACE activity (27.4 +/- 8.4 nM His-Leu-ml(-1)) nor ACE genotype showed a statistically significant association with any of the endurance phenotypes measured. The weak correlations observed included r = -0.122 (P = 0.229) for the relationship between delta efficiency (23.9 +/- 2.5%) and circulating ACE activity and r = 0.134 (P > 0.6) for the relationship between maximal aerobic power (149.1 +/- 22.9 ml kg(-2/3) min(-1)) and circulating ACE activity. The data do not support a role for systemic ACE activity in the regulation of endurance performance in sedentary individuals, extending this observation to a large female cohort.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Day SH,Gohlke P,Dhamrait SS,Williams AGdoi
10.1007/s00421-006-0309-3subject
Has Abstractpub_date
2007-01-01 00:00:00pages
11-8issue
1eissn
1439-6319issn
1439-6327journal_volume
99pub_type
杂志文章abstract：:Prolonged immobilization of the human body results in functional impairments and musculoskeletal system deconditioning that may be attenuated by adequate muscle exercise. In a 56-day horizontal bed rest campaign involving voluntary males we investigated the effects of vibration muscle exercise (RVE, 2x6 min daily) on ...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-006-0160-6
更新日期：2006-06-01 00:00:00
abstract：:Information concerning the validity and reliability of commercial on-line gas analysis systems is limited. The aim of this study was to provide a comparison of the validity and reliability of three on-line systems (Oxycon Alpha, Oxycon Pro and Pulmolab EX670) with that of Douglas bags. Two separate studies were conduc...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-001-0572-2
更新日期：2002-03-01 00:00:00
abstract：:In adults, exercise is a powerful and natural stimulator of immune cells and adhesion molecules. Far less is known about these exercise responses during childhood and whether or not exercise in real-life activities of healthy children might influence immune responses. We compared laboratory exercise (10 x 2 min period...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210100505
更新日期：2001-11-01 00:00:00
abstract：:Whole-Body vibration (WBV) may lead to muscle contractions via reflex activation of the primary muscle spindle (Ia) fibres. WBV has been reported to increase muscle power in the short term by improved muscle activation. The present study set out to investigate the acute effects of a standard WBV training session on vo...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-002-0723-0
更新日期：2003-01-01 00:00:00
abstract：:Fifteen healthy men performed a 5-week training program comprising four sets of seven unilateral, coupled concentric-eccentric knee extensions 2-3 times weekly. While eight men were assigned to training using a weight stack (WS) machine, seven men trained using a flywheel (FW) device, which inherently provides variabl...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0583-8
更新日期：2008-02-01 00:00:00
abstract：:This study was undertaken to elucidate the impact of long-term physical training on the modulation of stretch reflex excitability. To this end, electromyographic activities of the soleus muscle in response to quick toe-up rotation were compared between highly trained endurance runners (n = 8) and non-trained control s...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2351-7
更新日期：2012-10-01 00:00:00
abstract：:Beta-endorphin (betaE) is an important reliever of pain. Various stressors and certain modalities of physiotherapy are potent inducers of the release of endogenous betaE to the blood stream. Most forms of exercise also increase blood betaE level, especially when exercise intensity involves reaching the anaerobic thres...
journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-007-0469-9
更新日期：2007-07-01 00:00:00
abstract：:Mathematical models of the acid-base chemistry of blood based upon mass action and mass balance equations have become popular as diagnostic tools in intensive care. The reference models using this approach are those based on the strong ion approach, but these models do not currently take into account the effects of ox...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-009-1244-x
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:This study compared the effect of periodised versus non-periodised (NP) resistance training on neuromuscular adaptions in older adults. METHODS:Forty-one apparently healthy untrained older adults (female = 21, male = 20; 70.9 ± 5.1 years; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified t...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3605-1
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2) is representative of pulmonary arterial blood flow in individuals without pulm...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-018-3884-1
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:Vascular dysfunction has been demonstrated in patients with Alzheimer's disease (AD). Exercise is known to positively affect vascular function. Thus, the aim of our study was to investigate exercise-induced effects on vascular function in AD. METHODS:Thirty-nine patients with AD (79 ± 8 years) were recruited a...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04447-w
更新日期：2020-10-01 00:00:00
abstract：:The objective of this study was to assess the effects of whole-body vibration (WBV) on lumbar muscle oxygenation oscillations in healthy men based on the wavelet transform of near-infrared spectroscopy signals. Twelve healthy participants were exposed to WBV at frequencies of 3, 4.5 and 6 Hz while muscle oxygenation s...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2298-0
更新日期：2012-08-01 00:00:00
abstract：:The purpose of this study was to compare the effects of active vs. passive recovery on the time to exhaustion for intermittent runs (15 s) at supramaximal velocity (120% of maximal aerobic speed). Twelve male subjects performed a graded test, an intermittent run to exhaustion with active recovery (50% of maximal aerob...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-003-0834-2
更新日期：2003-08-01 00:00:00
abstract：PURPOSE:We investigated the effects of a 3-week dietary periodization on immunity and sleep in triathletes. METHODS:21 triathletes were divided into two groups with different nutritional guidelines during a 3-week endurance training program including nine twice a day sessions with lowered (SL group) or maintained (CON...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-016-3446-3
更新日期：2016-10-01 00:00:00
abstract：:SCUBA diving is regularly associated with asymptomatic changes in cardiac, pulmonary and vascular function. The aim of this study was to evaluate the changes in vascular/endothelial function following SCUBA diving and to assess the potential difference between two breathing gases: air and nitrox 36 (36% oxygen and 64%...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2187-6
更新日期：2012-06-01 00:00:00
abstract：:Early effects of a resistance training program include neural adaptations at multiple levels of the neuraxis, but direct evidence of central changes is lacking. Plasticity exhibited by multiple supraspinal centers following training may alter slow negative electroencephalographic activity, referred to as movement-rela...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1432-8
更新日期：2010-07-01 00:00:00
abstract：:A hypoxic model was used to investigate changes in localized cerebral and muscle haemodynamics during knee extension (KE) in healthy individuals. Thirty-one young healthy volunteers performed one set of KE until failure under hypoxia (14 % O(2)) or normoxia (21 % O(2)) at 50, 75 or 100 % of 1 repetition maximum, in ra...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2408-7
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Our purpose was to compare supramaximal versus submaximal intensity eccentric training performed until volitional fatigue. METHODS:Thirty-two young adults (19 males) were randomized into one of three groups: (1) ECC110 performed eccentric (ECC) only contractions at 110% of concentric (CON) 1-repetition maximum...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3700-3
更新日期：2017-10-01 00:00:00
abstract：:The present study examined the effects of raising both skin temperature and core temperature, separately and in combination, on perceptions of heat-related fatigue (alertness, contentment, calmness and thermal comfort), cardiovascular function and on objective measures of cognitive performance (reaction time and accur...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0677-y
更新日期：2008-09-01 00:00:00
abstract：:This study was undertaken to determine the cell adhesion molecule profile of CD4+, CD8hi and CD56+ lymphocytes, which are mobilised to and from the peripheral blood during and after prolonged aerobic exercise. Ten healthy males (21-35 years old) were tested on two occasions, separated by at least 14 days. On the first...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000374
更新日期：2001-04-01 00:00:00
abstract：:We have previously shown that Achilles tendon length is related to walking economy on the flat, presumably because of increased stretch-shortening cycle elastic energy savings. In addition, greater walking economy in African American (AA) women compared to European American (EA) women is explained by longer Achilles t...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-010-1816-9
更新日期：2011-08-01 00:00:00
abstract：:A routine method to determine total haemoglobin mass (tHb) in clinical practice and sports medicine is non-existent. Radioactive tracers or other dilution procedures like the common CO-rebreathing method (Proc(com)) are impractical, the latter in particular because of the relatively long time of respiration. According...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-0050-3
更新日期：2005-12-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) at selected acupoints on enhancing the rate of muscle force recovery after strenuous knee extension/flexion exercise. Ten male and seven female healthy young adults participated in this study in which they perform...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0463-2
更新日期：2007-08-01 00:00:00
abstract：:We investigated the alteration in flow-dependent-dilatation in the orthostatic intolerance occurring after bed-rest deconditioning. Eight men [aged mean (SEM) 32 (2) years] underwent two consecutive periods of 7 days of head-down-tilt (HDT, -6 degrees) during bed rest. A control age and sex matched group [n = 8, 30 (2...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s004210100483
更新日期：2001-09-01 00:00:00
abstract：:Exercise critical power (CP) has been shown to represent the highest sustainable work rate (WR) in patients with chronic obstructive pulmonary disease (COPD). Parameter estimation, however, depends on 4 high-intensity tests performed, on different days, to the limit of tolerance (T(lim)). In order to establish a milde...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-0064-x
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:Long static or intense dynamic apnoea-like high-altitude exposure is inducing hypoxia. Adenosine is known to participate to the adaptive response to hypoxia leading to the control of heart rate, blood pressure and vasodilation. Extracellular adenosine level is controlled through the equilibrative nucleoside tra...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04523-1
更新日期：2021-01-01 00:00:00
abstract：:Skin surface cooling has been shown to improve orthostatic tolerance; however, the influence of severe heat stress on cardiovascular and cerebrovascular responses to skin cooling remains unknown. Nine healthy males, resting supine in a water-perfusion suit, were heated to +1.0 and +2.0 degrees C elevation in body core...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-009-1298-9
更新日期：2010-05-01 00:00:00
abstract：:To identify the effect of normal breathlessness sensation elicited during intense intermittent exercise at exhaustion on limitation of exercise maintenance (Ex), the contribution of the flow-resistive unloading effect of normoxic helium-oxygen breathing on the breathlessness sensation to the change in the Ex was exami...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00421-004-1094-5
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate how much the distance between stimulation electrodes affects the knee extension torque in tetanic, electrically elicited contractions. METHODS:Current pulses of progressively larger amplitude, from 0 mA to maximally tolerated intensities, were delivered at 20 pps to...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-015-3289-3
更新日期：2016-02-01 00:00:00
abstract：:We have recently demonstrated that electromyogram (EMG) amplitude of the frowning muscles correlates with perception of effort during leg-extension exercise. However, during aerobic exercise the relationship between facial EMG and perception of effort has never been investigated. The aim of the present study was to in...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2138-2
更新日期：2012-05-01 00:00:00
