Abstract:
:Immunohistochemical localization of prostaglandin (PG) F2 alpha synthesized during recirculation following experimental forebrain ischemia was studied in Mongolian gerbils. The bilateral carotid arteries were clamped for 5 minutes, and the brains were frozen in situ after 5 minutes of recirculation. Sham-operated gerbils not subjected to arterial occlusion served as controls. Cryostat sections containing dorsal hippocampus 10 microns in thickness were incubated in rabbit anti-PGF2 alpha serum and stained with avidin-biotin-peroxidase complex after fixation in carbodi-imide and Zamboni's solution. In specimens from control animals, blood vessels were faintly stained with anti-PGF2 alpha serum, while neurons and glial cells were less intensely stained or unstained. Specimens from reperfused gerbils demonstrated strongly positive staining for PGF2 alpha in blood vessels, neurons (especially hippocampal pyramidal neurons), and glial cells. Staining for PGF2 alpha in the reperfused animals was substantially diminished by pretreatment with indomethacin (10 mg/kg, i.p.). The results indicate that recirculation after forebrain ischemia results in an increase in PGF2 alpha in neurons, glial cells, and blood vessels.
journal_name
Neurol Med Chir (Tokyo)journal_title
Neurologia medico-chirurgicaauthors
Nakagomi T,Sasaki T,Ogawa H,Noguchi M,Saito I,Takakura Kdoi
10.2176/nmc.30.223subject
Has Abstractpub_date
1990-04-01 00:00:00pages
223-8issue
4eissn
0470-8105issn
1349-8029pii
JST.Journalarchive/nmc1959/30.223journal_volume
30pub_type
杂志文章abstract::Appropriate management of moyamoya syndrome associated with Graves' disease is undetermined because of the rarity of this combination. Patients tend to present with cerebrovascular events such as transient ischemic attack (TIA) in a thyrotoxic state, which is relieved by proper antithyroid therapy. Four patients with ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.50.977
更新日期:2010-01-01 00:00:00
abstract::A 63-year-old female presented with an unusual case of microcystic meningioma manifesting as a 4-year history of unsteady gait, dysarthria, and hearing loss. Computed tomography disclosed a large hypodense mass in the right cerebellopontine angle, clivus, and middle fossa, with slight contrast enhancement. T1-weighted...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.37.407
更新日期:1997-05-01 00:00:00
abstract::Reappearance of symptoms of cranial nerve dysfunction is not uncommon after successful microvascular decompression (MVD). The purpose of this study was to report two quite unusual cases of recurrent and newly developed hemifacial spasm (HFS) caused by a new conflicting artery more than 20 years after the first success...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.cr.2015-0227
更新日期:2016-01-01 00:00:00
abstract::The efficacy of gabapentin monotherapy was investigated against both acute or chronic radicular pain caused by lumbar disk hernia (LDH) or lumbar spinal stenosis (LSS). Seventy-eight patients with radicular pain, 10 males and 68 females aged 23 to 76 years (mean 49.4 years), caused by LSS in 45 patients or LDH in 33 p...
journal_title:Neurologia medico-chirurgica
pub_type: 临床试验,杂志文章
doi:10.2176/nmc.50.1070
更新日期:2010-01-01 00:00:00
abstract::Adequate exposure of the distal internal carotid artery (ICA) for carotid endarterectomy may be difficult to achieve because of the position of the mandible and associated soft tissues. A simple yet effective use of a head frame is described to gain several centimeters of exposure of the distal ICA. The patient's head...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.43.271
更新日期:2003-05-01 00:00:00
abstract::Parent artery occlusion (PAO) is an alternative to surgical clipping or endovascular endosaccular coil embolization for the management of cerebral aneurysms. Most giant and fusiform aneurysms are not amenable to endosaccular coil embolization due to anatomical considerations, such as a broad-neck. However, majority of...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::The effects of cervical spinal cord stimulation (CSCS) on glucose consumption were examined in two patients with prolonged disturbance of consciousness due to head injuries. Several clinical parameters, including glucose consumption using positron emission tomography (PET) with [18F]2-fluoro-2-deoxy-D-glucose (FDG), w...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.35.797
更新日期:1995-11-01 00:00:00
abstract::Cervical spinal neurinomas are benign tumors that arise from nerve roots. Based on their location, these tumors can also take the form of a dumbbell-shaped mass. Treatment strategies for these tumors have raised several controversial issues such as appropriate surgical indications and selection of surgical approaches ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.ra.2014-0421
更新日期:2015-01-01 00:00:00
abstract::The angiographic findings in 31 Yugoslav moyamoya patients, 16 males and 15 females, including four children, were studied by conventional or digital subtraction angiography. The angiographic findings were reviewed for stenoocclusive lesions, form of the main cerebral arteries, transdural anastomoses, and basal vascul...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.37.512
更新日期:1997-07-01 00:00:00
abstract::Tumor tissues obtained from two patients with growth hormone-producing pituitary adenomas were cultured and treated with bromocriptine, then examined for morphological changes. Untreated tumor cells (controls) were morphologically well preserved and in terms of growth hormone secretion. Tumor cells exposed to bromocri...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.29.6
更新日期:1989-01-01 00:00:00
abstract::The authors report a case of cerebellopontine angle epidermoid presenting as typical hemifacial spasm. A 33-year-old male had experienced intermittent right hemifacial spasm for 2 years. Cranial nerve examination was otherwise normal, including auditory and trigeminal nerve functions. Metrizamide computed tomographic ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.31.410
更新日期:1991-07-01 00:00:00
abstract::Neural progenitor cells (NPCs) are expected to be useful donor sources for cell transplantation therapy in Parkinson's disease. However, control of the differentiational lineage, especially into dopaminergic neurons, is still difficult. Thus, genetic modification of NPCs to produce l-dopa is potentially useful. The pr...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.44.344
更新日期:2004-07-01 00:00:00
abstract::Acute coagulopathy is common after traumatic brain injury (TBI), particularly in severe cases of acute subdural hemorrhage (ASDH). Although acute coagulopathy is associated with poor outcomes, the optimal treatment strategy remains unknown. Here, we report the initial results of an empirical cryoprecipitate transfusio...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.oa.2019-0062
更新日期:2019-10-15 00:00:00
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journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.45.164
更新日期:2005-03-01 00:00:00
abstract::A 55-year-old man presented with a rare case of multiple isolated sinus dural arteriovenous fistulas (AVFs) associated with antithrombin (AT) III deficiency manifesting as sudden onset of headache and gait disturbance. Increased arterial shunting flow had caused intraventricular hemorrhage after incomplete repeated tr...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.48.455
更新日期:2008-10-01 00:00:00
abstract::A 31-year-old woman with moyamoya disease presented with choreiform movements persisting for 4.5 years. Magnetic resonance imaging showed a fine vascular plexus in the base of the brain but no parenchymal brain damage. Cerebral angiography revealed intracranial vascular abnormalities compatible with moyamoya disease. ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.48.390
更新日期:2008-09-01 00:00:00
abstract::Transforaminal full-endoscopic lumbar discectomy (TELD) can be performed under local anesthesia. However, there have been no reports on risk factors for a change in vital signs or the need for additional medications to maintain adequate analgesia during this procedure. The purpose of this study was to identify risk fa...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.oa.2020-0275
更新日期:2021-01-28 00:00:00
abstract::The relationships between event-related potential (P300), higher brain functions, and regional cerebral blood flow (rCBF) were examined in 31 neurosurgical patients. The P300 latency, evaluated by an acoustic "odd-ball" paradigm, was normal in 14 and prolonged in 17 patients. Fourteen of 17 prolonged P300 patients had...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.33.146
更新日期:1993-03-01 00:00:00
abstract::A 60-year-old female presented with sudden onset of severe headache and back pain, followed by nausea. The initial head computed tomography (CT) scan revealed posterior fossa subarachnoid hemorrhage (SAH). Spinal T(2)-weighted magnetic resonance imaging demonstrated SAH, and a homogeneous and slightly low signal inten...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.51.649
更新日期:2011-01-01 00:00:00
abstract::The involvement of nitric oxide synthase (NOS) in ischemia was evaluated by detecting the expression of neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS) by the immunohistochemical method in the rat model of middle cerebral artery (MCA) occlusion. Transient MCA occlusion (2 hours) was induced in 32...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.41.63
更新日期:2001-02-01 00:00:00
abstract::A 41-year-old female suffered transient ischemic attack. Cerebral angiography revealed occlusion of the left internal carotid artery at the cervical portion and collateral pathways consisting of transpial anastomosis and parenchymal anastomosis from the posterior circulation. Five years later, the second angiography w...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.31.957
更新日期:1991-12-01 00:00:00
abstract::An 18-year-old male presented with a pineal region germinoma with hearing impairment as the chief complaint. Magnetic resonance image demonstrated a well-enhanced multi-cystic tumor extending into the upper fourth ventricle and wall of the bilateral lateral ventricles. Audiometry revealed bilateral mild hearing impair...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.42.301
更新日期:2002-07-01 00:00:00
abstract::A rare case of an epidermoid tumor lying within Meckel's cave is reported. A 27-year-old housewife presented with complaints of right facial hypesthesia for two and a half years. On examination she had partial loss of touch sensation in the right trigeminal nerve distribution. Magnetic resonance imaging revealed a tum...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.40.74
更新日期:2000-01-01 00:00:00
abstract::Adverse effects of intravenous acetazolamide administration for evaluation of cerebrovascular reactivity using brain perfusion single-photon emission computed tomography (SPECT) were prospectively investigated in 100 patients with major cerebral artery, atherosclerotic, and steno-occlusive diseases. All patients under...
journal_title:Neurologia medico-chirurgica
pub_type: 临床试验,杂志文章
doi:10.2176/nmc.51.479
更新日期:2011-01-01 00:00:00
abstract::Head injuries due to high-velocity missiles and shrapnel as a result of military conflicts have become a very important cause of death or severe neurological deficits. Military-type missiles have high velocities and transfer higher amounts of energy to neural tissue, compared to civil-type missiles. This physical phen...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.45.281
更新日期:2005-06-01 00:00:00
abstract::A 32-year-old man presented with a rare case of spontaneous intracranial hypotension (SIH) associated with dural sinus thrombosis (DST) manifesting as severe postural headache which was relieved by lying down. Initial cerebrospinal fluid pressure was low. He was treated with hydration and rest under a diagnosis of SIH...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.47.555
更新日期:2007-12-01 00:00:00
abstract::A 52-year-old man complaining of headache and nuchal pain was treated initially under a diagnosis of bacterial meningitis. The meningitis resisted antibiotic therapy, and one week later was complicated by a ruptured retropharyngeal abscess, which led to the correct diagnosis of osteomyelitis of the odontoid process of...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.42.447
更新日期:2002-10-01 00:00:00
abstract::A 62-year-old woman presented with a rare case of subependymoma associated with prominent Rosenthal fibers located in the left lateral ventricle manifesting as right hemiparesis and mild motor aphasia. The tumor was well demarcated and consisted of clusters of round nuclei embedded in an abundant gliofibrillary matrix...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.50.933
更新日期:2010-01-01 00:00:00
abstract::The protective effect of nilvadipine, a Ca2+ antagonist, on cerebral ischemia was investigated in spontaneously hypertensive rats. The 12-week-old animals were treated for 7 days with either nilvadipine or vehicle using osmotic pumps implanted subcutaneously. Group 1 animals (n = 10) received the vehicle, and Group 2 ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.36.151
更新日期:1996-03-01 00:00:00
abstract::Cancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base. The treatment of these tumors affecting the skull base is complex due to the significant anatomical features. We examined 25 patients, 17 males and 8 females with mean age 61 +/- 2 years...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.50.20
更新日期:2010-01-01 00:00:00