The H295R system for evaluation of endocrine-disrupting effects.

Abstract:

:The present studies were undertaken to evaluate the utility of the H295R system as an in vitro assay to assess the potential of chemicals to modulate steroidogenesis. The effects of four model chemicals on the expression of ten steroidogenic genes and on the production of three steroid hormones were examined. Exposures with individual model chemicals as well as binary mixtures were conducted. Although the responses reflect the known mode of action of the various compounds, the results show that designating a chemical as "specific inducer or inhibitor" is unwise. Not all changes in the mixture exposures could be predicted based on results from individual chemical exposures. Hormone production was not always directly related to gene expression. The H295R system integrates the effects of direct-acting hormone agonists and antagonists as well as chemicals affecting signal transduction pathways for steroid production and provides data on both gene expression and hormone secretion which makes this cell line a valuable tool to examine effects of chemicals on steroidogenesis.

journal_name

Ecotoxicol Environ Saf

authors

Gracia T,Hilscherova K,Jones PD,Newsted JL,Zhang X,Hecker M,Higley EB,Sanderson JT,Yu RM,Wu RS,Giesy JP

doi

10.1016/j.ecoenv.2006.06.012

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

293-305

issue

3

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(06)00138-2

journal_volume

65

pub_type

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