Abstract:
:The present studies were undertaken to evaluate the utility of the H295R system as an in vitro assay to assess the potential of chemicals to modulate steroidogenesis. The effects of four model chemicals on the expression of ten steroidogenic genes and on the production of three steroid hormones were examined. Exposures with individual model chemicals as well as binary mixtures were conducted. Although the responses reflect the known mode of action of the various compounds, the results show that designating a chemical as "specific inducer or inhibitor" is unwise. Not all changes in the mixture exposures could be predicted based on results from individual chemical exposures. Hormone production was not always directly related to gene expression. The H295R system integrates the effects of direct-acting hormone agonists and antagonists as well as chemicals affecting signal transduction pathways for steroid production and provides data on both gene expression and hormone secretion which makes this cell line a valuable tool to examine effects of chemicals on steroidogenesis.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Gracia T,Hilscherova K,Jones PD,Newsted JL,Zhang X,Hecker M,Higley EB,Sanderson JT,Yu RM,Wu RS,Giesy JPdoi
10.1016/j.ecoenv.2006.06.012subject
Has Abstractpub_date
2006-11-01 00:00:00pages
293-305issue
3eissn
0147-6513issn
1090-2414pii
S0147-6513(06)00138-2journal_volume
65pub_type
杂志文章abstract::Cadmium exposure is associated with renal dysfunction. However, the outcome of renal function in subjects who have had a reduction in cadmium exposure for years has not been completely clarified, particularly for individuals with normal baseline renal function. In this study, we used a nomogram model to predict renal ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110251
更新日期:2020-03-15 00:00:00
abstract::The toxicity and environmental risk of chemicals, such as the antiepileptic drug carbamazepine (CBZ), is commonly assessed using standardized laboratory tests and laboratory-to-field extrapolation. To investigate the toxicity of CBZ to aquatic key organisms in a more complex and environmentally relevant scenario, we c...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.109481
更新日期:2019-11-15 00:00:00
abstract::With the continued increase of technological uses of cerium oxide nanoparticles (CeO2 NPs or nanoceria) and their unregulated disposal, the accumulation of nanoceria in the environment is inevitable. Concomitantly, atmospheric carbon dioxide (CO2) levels continue to rise, increasing the concentrations of bicarbonate i...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.05.041
更新日期:2019-09-30 00:00:00
abstract::Microalgae play an important role in arsenic (As) bioaccumulation and biogeochemical cycling in marine ecosystems. Marine microalgal growth and As biotransformation processes depend on environmental factors, including salinity, temperature, and nutrient concentrations, and data in this regard are available in the lite...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110797
更新日期:2020-09-15 00:00:00
abstract:AIM:The city of L'Aquila (central Italy) was hit by a strong earthquake in 2009 that caused the collapse of several buildings, deaths and injured people. In the following years, a great number of building sites were activated, building workers resulted intensely exposed and represent a relevant target for research on e...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110989
更新日期:2020-10-15 00:00:00
abstract::Detection of mutagenic pollution in natural environment is difficult as there are thousands of known chemical mutagens, and they have mutagenic effects usually at very low concentrations. Plants are able to accumulate various substances, including mutagens, in their tissues. Here, we demonstrate that rapid detection o...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2007.04.004
更新日期:2008-06-01 00:00:00
abstract::The 24-h toxicity of 20 substituted chlorophenols upon Lebistes reticulatus has been determined. The biological results have been tentatively connected with several of the following six parameters: logarithm of the octanol-water partition coefficient (log P); index of molecular connectivity (1 chi v); molecular refrac...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/0147-6513(84)90026-5
更新日期:1984-06-01 00:00:00
abstract::Resistance to treatments with Temephos or plant derived oil, Pb-CVO, between a field collected Wild Strain (WS) and a susceptible Laboratory Strain (LS) of Ae. aegypti were measured. The Temephos (0.1mg/L) showed the greatest percentage of mosquito mortality compared to Pb-CVO (1.5mg/L) in LS Ae. aegypti. However, WS ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.01.026
更新日期:2017-05-01 00:00:00
abstract::Sulfometuron-methyl is a broad-spectrum herbicide, used throughout Brazil; however, its environmental impacts in biochar (BC) amended soils is not fully understood. Biochar is known to enhance soil quality but can also have undesired effects such as altering the bioavailability and behavior of herbicides. Microbial co...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111222
更新日期:2021-01-01 00:00:00
abstract::The usual approaches used in ecological risk assessment have been based on individual and population level standard procedures. Although these have been important tools to assess adverse effects on ecosystems, they are generally simplified and therefore lack ecological realism. Microcosm studies using meiobenthic comm...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.09.040
更新日期:2018-01-01 00:00:00
abstract::Preimplantation rat embryos (8-cell, morulae, blastocysts) were incubated for 24 hr in vitro in a Brinster medium with or without cadmium chloride (1 microgram/ml). CdCl2 arrested the development of both the 8-cell and morulae into blastocysts. Morphologic observations revealed the 8-cell embryo to have shrunken cells...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/0147-6513(86)90013-8
更新日期:1986-12-01 00:00:00
abstract::Cadmium (Cd) is a highly toxic element and non-essential to human. Herein, the source and fate of Cd were examined in a typical sediment profile from the North River, South China, which was affected by the massive Pb-Zn smelting activities for decades. An exceptionally high enrichment of Cd, 107-441 mg/kg, was observe...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110529
更新日期:2020-06-15 00:00:00
abstract::Nodularin (NODLN) is a hepatotoxin produced by the cyanobacterium Nodularia spumigena, which occurs regularly in the Baltic Sea. The primary aim of this study was to study the transfer of NODLN to three-spined stickleback (Gasterosteus aculeatus L.), herring (Clupea harengus membras L.), and salmon (Salmo salar L.), w...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2006.02.006
更新日期:2007-03-01 00:00:00
abstract::Chromium (Cr) contamination is a potential threat to the agricultural soil. Arbuscular mycorrhizal (AM) fungi have potential to remediate the heavy metal polluted soils. It was hypothesized that Cr phytoremediation potentiality of AM fungi could be enhanced in combination with saprophytic filamentous fungi and soil am...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110869
更新日期:2020-09-15 00:00:00
abstract::Selenium (Se) is considered a beneficial element to higher plants based on its regulation of antioxidative system under abiotic or biotic stresses. However, the limit of beneficial and toxic physiological effects of Se is very narrow. In the present study, the antioxidant performance, nutritional composition, long-dis...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111016
更新日期:2020-10-15 00:00:00
abstract::Humans are exposed to polybrominated diphenyl ethers (PBDEs) via ingestion of food, dust inhalation, and dermal absorption. Exposure to PBDEs via the placenta and breast milk is a special and important pathway in infants. This nested case-control study aimed to investigate the levels of PBDEs in maternal serum and col...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.110623
更新日期:2020-07-15 00:00:00
abstract::Ecological risk assessment is defined both in theory and in practice. To do it properly, we need to know what targets we are protecting, but these targets are not always obvious and clearly defined. The pragmatic approach, used most generally in the context of environmental protection legislation, is the risk quotient...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1006/eesa.1998.1636
更新日期:1998-05-01 00:00:00
abstract::Oil water-soluble fractions (WSFs) compounds have low persistence in water; evaporating in a matter of hours to days. Nonetheless, they pose high toxicity to exposed biota. Their effects may be instantaneous or delayed, affecting, respectively, mainly survival vs growth and reproduction. We investigated the effects of...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.03.083
更新日期:2019-07-30 00:00:00
abstract::The newt (Pleurodeles waltl) is an amphibian species used in a mutagenicity test (micronucleus). This study was carried out to establish if the inducibility of hepatic cytochromes P450 of this species is similar to that of the rat. Our results showed that the newt is characterized by a lower level of hepatic cytochrom...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/0147-6513(92)90042-2
更新日期:1992-10-01 00:00:00
abstract::Arsenic (As) a non-essential element is of particular concern with respect to harmful effects on plant metabolism. While extensive studies have been conducted on the physiological responses of plants to increase As concentrations, however, molecular differences elucidating species-specific changes remain largely unkno...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111744
更新日期:2021-01-15 00:00:00
abstract::Three-dimensional (3D) porous graphene oxide-maize amylopectin (GO-MA) composites with controllable pore-sizes composites in the range of 6-40 nm were prepared by facile hydrothermal-assisted assembly approaches. The morphologies, pore sizes, specific surface area (SSA) and compositions of GO-MAx:y composites with and...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.03.069
更新日期:2019-07-30 00:00:00
abstract::The extensive industrial application of graphene oxide (GO), has increased its exposure risk to various aquatic organisms and its potential to affect the toxicity of other environmental pollutants. In this study, we investigated the combined toxicity of GO and copper on the freshwater microalga Scenedesmus obliquus, u...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2016.06.029
更新日期:2016-10-01 00:00:00
abstract::Chromium (Cr) is a highly toxic environmental pollutant that negatively affects plant growth and development. Thus, remediating Cr from soil or increasing plant tolerance against Cr stress is urgent. Organic acids are recognized as agents of phytoremediation and as exogenous protectants, but using maleic acid (MA) to ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2017.06.010
更新日期:2017-10-01 00:00:00
abstract::Exposure to toxic and essential metals is thought to be reflected by corresponding metal concentrations in tissues. However, toxic and essential metals may influence each other in regard to their retention in the body. Therefore a basic diet containing four toxic metals (As 7, Cd 9, Ni 13, and Pb 20 ppm) and adequate ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/0147-6513(87)90071-6
更新日期:1987-12-01 00:00:00
abstract::Coal excavation and refinement processes generate substantial volumes of contaminated effluent that may be detrimental to aquatic ecosystems. As such, understanding the impacts of coal mine water releases on aquatic animals and ecosystems is essential for effectively managing and protecting neighboring environments. S...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2016.03.003
更新日期:2016-07-01 00:00:00
abstract::2,4,6-tribromophenol (TBP) is generally used as a brominated flame retardant but is produced in the degradation of tetrabromobisphenol-A. Although TBP is frequently detected in the environment and in various biota, including fish species, we still know little about its toxicity and environmental health risk. Here we i...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2020.111207
更新日期:2020-12-15 00:00:00
abstract::The molecular mechanisms of the differences among the Cd tolerance and accumulation of different pak choi cultivars are essential to further breed Cd-safe genotypes pak choi. In our research, via morphological comparison, qRT-PCR and yeast function complementary approaches, we explored the differences of Cd tolerance ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2019.109571
更新日期:2019-11-15 00:00:00
abstract::Effluent from tannery, electroplating and electronic industries contain chromium which is highly toxic. This paper reports isolation of chromium tolerant microorganisms from solid waste as well as liquid effluent of an electroplating industry. Nine isolates were obtained that can tolerate chromium concentration up to ...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2007.12.017
更新日期:2008-11-01 00:00:00
abstract::Effects of chronic concentrations of linuron (0, 0.5, 5, 15, 50, and 150 micrograms/L) were studied in indoor, macrophyte dominated, freshwater microcosms. The concentrations were kept at a constant level for 4 weeks. This paper is the first in a series of two and summarizes the course of the linuron concentrations in...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1006/eesa.1997.1555
更新日期:1997-10-01 00:00:00
abstract::We aimed to evaluate the effect of GSM-like radiofrequency electromagnetic radiation (RF-EMR) on the oogenesis, and spermiogenesis of Xenopus laevis, and so the development of the embryos obtained from Normal Females+Normal Males (i.e. "N(F)+N(M)"); Normal Females+RF-exposed Males (i.e. "N(F)+RF(M)"); RF-exposed Femal...
journal_title:Ecotoxicology and environmental safety
pub_type: 杂志文章
doi:10.1016/j.ecoenv.2016.03.015
更新日期:2016-07-01 00:00:00