Expression of the short fimbriae of Porphyromonas gingivalis is regulated in oral bacterial consortia.

Abstract:

:The Mfa1 protein of Porphyromonas gingivalis is the structural subunit of the short fimbriae and mediates coadhesion between P. gingivalis and Streptococcus gordonii. We utilized a promoter-lacZ reporter construct to examine the regulation of mfa1 expression in consortia with common oral plaque bacteria. Promoter activity of mfa1 was inhibited by S. gordonii, Streptococcus sanguinis and Streptococcus mitis. In contrast, Streptococcus mutans, Streptococcus cristatus, Actinomyces naeslundii, Actinobacillus actinomycetemcomitans and Fusobacterium nucleatum did not affect mfa1 expression. Expression of SspA/B, the streptococcal receptor for Mfa1, was not required for regulation of mfa1 promoter activity. Proteinaceous molecule(s) in oral streptococci may be responsible for regulation of Mfa1 expression. Porphyromonas gingivalis is capable of detecting heterologous organisms, and responds to selected organisms by specific gene regulation.

journal_name

FEMS Microbiol Lett

authors

Park Y,James CE,Yoshimura F,Lamont RJ

doi

10.1111/j.1574-6968.2006.00357.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

65-71

issue

1

eissn

0378-1097

issn

1574-6968

pii

FML357

journal_volume

262

pub_type

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