Abstract：
:The opening of voltage sensitive calcium channels is an important event in the progression of irreversible shock, allowing the entry of toxic amounts of calcium (Ca2+) into the cells. Because intracellular magnesium (Mg2+) can efflux through these same channels, changes in serum Mg2+ may reflect the patency of these channels. In this study, electrolytes and selected serum enzymes were monitored in chronically instrumented conscious dogs to follow the progression of shock following a fixed volume hemorrhage. Plasma enzymes indicative of liver damage were elevated only in the terminal phase of hemorrhagic decompensation. A significant increase in serum Mg2+ was evident 60 min following hemorrhage, even though arterial pressure was still recovering. Serum Mg2+ continued to rise throughout the recovery and decompensating phases of shock. Verapamil treatment, which increased survival time and survival rate, significantly attenuated the changes in serum Mg2+ which normally followed hemorrhage. These results indicate that serum Mg2+ may be a useful indicator of the severity and the progression of hemorrhagic shock.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Carroll RG,Iams SG,Pryor WH Jr,Allison EJ Jrdoi
10.1016/0300-9572(90)90097-xsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
41-52issue
1eissn
0300-9572issn
1873-1570pii
0300-9572(90)90097-Xjournal_volume
19pub_type
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