Neuroprotection and thrombolysis: combination therapy in acute ischaemic stroke.

Abstract:

:The administration of oral aspirin within 48 h and tissue plasminogen activator within 3 h of ischaemic stroke onset remain the only treatments that have been shown to have clinical benefit. There has been much excitement about neuroprotection over the last two decades, as it may minimise the harmful effects of ischaemic neuronal damage. Although each step along the ischaemic cascade offers a potential target for therapeutic intervention, and neuroprotection has shown benefit in animal studies, this has been difficult to translate to humans. Some hope has been offered by the recent finding that the free radical scavenger NXY-059 may improve outcomes in patients presenting within 6 h of onset of ischaemic stroke. There is logic to the idea that neuroprotection may be most effective when reperfusion has occurred with thrombolysis, as the neuroprotectant will have greater access to ischaemic tissue and the opportunity is presented to minimise free radical-mediated reperfusion injury. Numerous studies in animal models support this view, but the concept has not, as yet, been rigorously tested in humans.

authors

Ly JV,Zavala JA,Donnan GA

doi

10.1517/14656566.7.12.1571

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

1571-81

issue

12

eissn

1465-6566

issn

1744-7666

journal_volume

7

pub_type

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