Genome-wide approaches to understanding human ageing.

Abstract:

:The use of genomic technologies in biogerontology has the potential to greatly enhance our understanding of human ageing. High-throughput screens for alleles correlated with survival in long-lived people have uncovered novel genes involved in age-associated disease. Genome-wide longevity studies in simple eukaryotes are identifying evolutionarily conserved pathways that determine longevity. It is hoped that validation of these 'public' aspects of ageing in mice, along with analyses of variation in candidate human ageing genes, will provide targets for future interventions to slow the ageing process and retard the onset of age-associated pathologies.

journal_name

Hum Genomics

journal_title

Human genomics

authors

Kaeberlein M

doi

10.1186/1479-7364-2-6-422

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

422-8

issue

6

eissn

1473-9542

issn

1479-7364

journal_volume

2

pub_type

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