Abstract:
:The use of genomic technologies in biogerontology has the potential to greatly enhance our understanding of human ageing. High-throughput screens for alleles correlated with survival in long-lived people have uncovered novel genes involved in age-associated disease. Genome-wide longevity studies in simple eukaryotes are identifying evolutionarily conserved pathways that determine longevity. It is hoped that validation of these 'public' aspects of ageing in mice, along with analyses of variation in candidate human ageing genes, will provide targets for future interventions to slow the ageing process and retard the onset of age-associated pathologies.
journal_name
Hum Genomicsjournal_title
Human genomicsauthors
Kaeberlein Mdoi
10.1186/1479-7364-2-6-422subject
Has Abstractpub_date
2006-06-01 00:00:00pages
422-8issue
6eissn
1473-9542issn
1479-7364journal_volume
2pub_type
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