Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet.

abstract：OBJECTIVE:Accumulation of mitochondrial DNA (mtDNA) damage has been associated with aging and abnormal oxidative metabolism. We hypothesized that in human immunodeficiency virus-associated sensory neuropathy (HIV-SN), damaged mtDNA accumulates in distal nerve segments, and that a spatial pattern of mitochondrial dysfun...

journal_title：Annals of neurology

authors： Lehmann HC,Chen W,Borzan J,Mankowski JL,Höke A

更新日期：2011-01-01 00:00:00

abstract：:We studied rhesus monkeys with hemiparkinsonism or bilateral parkinsonism produced by unilateral or bilateral intracarotid administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Using a standardized clinical rating scale, 4 hemiparkinsonian monkeys showed a 13 to 56% (mean, 36%) spontaneous improvement during...

journal_title：Annals of neurology

authors： Kurlan R,Kim MH,Gash DM

更新日期：1991-06-01 00:00:00

abstract：:It has been proposed that early-onset familial Alzheimer's disease (FAD) and sporadic Alzheimer's disease (AD) have different causes, with FAD due to a single dominant gene with disease onset before the sixth decade, whereas sporadic AD has a later onset and is not associated with a dominant pattern of inheritance. Gi...

journal_title：Annals of neurology

authors： Swearer JM,O'Donnell BF,Drachman DA,Woodward BM

更新日期：1992-11-01 00:00:00

abstract：:Splice-site and missense mutations have been identified in tau associated with frontotemporal dementia with parkinsonism linked to chromosome 17. In this study we assessed the genetic contribution of tau mutations to three patient series with non-Alzheimer's (non-AD) degenerative dementia. The groups included (1) a co...

journal_title：Annals of neurology

authors： Houlden H,Baker M,Adamson J,Grover A,Waring S,Dickson D,Lynch T,Boeve B,Petersen RC,Pickering-Brown S,Owen F,Neary D,Craufurd D,Snowden J,Mann D,Hutton M

更新日期：1999-08-01 00:00:00

abstract：:We report the clinical, radiological, and neuropathological features of selective brainstem injury in an asphyxiated term infant. Disproportionate injury to thalamus, basal ganglia, and brainstem with relative sparing of cortex and subcortical white matter is observed occasionally after acute total asphyxia. Although ...

journal_title：Annals of neurology

authors： Roland EH,Hill A,Norman MG,Flodmark O,MacNab AJ

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Migraine is among the most common and debilitating neurological conditions. Familial hemiplegic migraine type 1 (FHM1), a monogenic migraine subtype, is caused by gain-of-function of voltage-gated CaV 2.1 calcium channels. FHM1 mice carry human pathogenic mutations in the α1A subunit of CaV 2.1 channels and a...

journal_title：Annals of neurology

authors： Eikermann-Haerter K,Arbel-Ornath M,Yalcin N,Yu ES,Kuchibhotla KV,Yuzawa I,Hudry E,Willard CR,Climov M,Keles F,Belcher AM,Sengul B,Negro A,Rosen IA,Arreguin A,Ferrari MD,van den Maagdenberg AM,Bacskai BJ,Ayata C

更新日期：2015-08-01 00:00:00

abstract：:To study distribution and patterns of nerve hypertrophy in chronic inflammatory demyelinating polyneuropathy (CIDP), magnetic resonance neurography with 3-dimensional reconstruction of short tau inversion recovery images was performed in 33 patients. This technique clearly showed longitudinal morphological changes fro...

journal_title：Annals of neurology

authors： Shibuya K,Sugiyama A,Ito S,Misawa S,Sekiguchi Y,Mitsuma S,Iwai Y,Watanabe K,Shimada H,Kawaguchi H,Suhara T,Yokota H,Matsumoto H,Kuwabara S

更新日期：2015-02-01 00:00:00

abstract：:Immunohistochemical examination of 20 Down's syndrome brains, using antibodies to alpha-, beta-, and gamma-synuclein, demonstrated many alpha-synuclein-positive Lewy bodies and dystrophic neurites in 50% of amygdala samples from Down's syndrome brains with Alzheimer's disease. Similar lesions were less common in other...

journal_title：Annals of neurology

authors： Lippa CF,Schmidt ML,Lee VM,Trojanowski JQ

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:Cerebral aneurysms can cause substantial morbidity and mortality, specifically if they rupture, leading to nontraumatic subarachnoid hemorrhage (SAH). This meta-analysis summarizes evidence about the accuracy of noninvasive computed tomographic (CT) angiography for diagnosing intracranial aneurysms in symptom...

journal_title：Annals of neurology

authors： Menke J,Larsen J,Kallenberg K

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:A study was undertaken to establish an enzyme-linked immunosorbent assay (ELISA) to detect JC virus (JCV)-specific antibodies in multiple sclerosis (MS) patients, and to evaluate its potential utility for identifying patients at higher or lower risk (ie, risk stratification) of developing progressive multifoc...

journal_title：Annals of neurology

authors： Gorelik L,Lerner M,Bixler S,Crossman M,Schlain B,Simon K,Pace A,Cheung A,Chen LL,Berman M,Zein F,Wilson E,Yednock T,Sandrock A,Goelz SE,Subramanyam M

更新日期：2010-09-01 00:00:00

abstract：:Early differential diagnosis of motor neuropathies (MN) and lower motor neuron diseases (LMND) is important, as prognosis and therapeutic approaches are different. We evaluated the diagnostic contribution of the biopsy of the motor branch of the obturator nerve and gracilis muscle in 21 consecutive patients in which, ...

journal_title：Annals of neurology

authors： Riva N,Iannaccone S,Corbo M,Casellato C,Sferrazza B,Lazzerini A,Scarlato M,Cerri F,Previtali SC,Nobile-Orazio E,Comi G,Quattrini A

更新日期：2011-01-01 00:00:00

abstract：:The authors report on a series of spontaneous intracranial hemorrhages associated with vein of Galen aneurysmal malformations (VGAMs). Thirty-four children with VGAMs have been treated at this institution since 1986. Eight children (24%) harbored the mural-type malformation, and 26 (76%) had the choroidal-type lesion....

journal_title：Annals of neurology

authors： Meyers PM,Halbach VV,Phatouros CP,Dowd CF,Malek AM,Lempert TE,Lefler JE,Higashida RT

更新日期：2000-06-01 00:00:00

abstract：:A 30-year-old man presented with decreased vision in the right eye of three weeks' duration. Examination indicated a chiasmal syndrome and evidence of subarachnoid hemorrhage. CAT scan showed a large suprasellar mass. Surgical intervention confirmed the presence of a globular lesion filled with blood clots involving m...

journal_title：Annals of neurology

authors： Fermaglich J,Kattah J,Manz H

更新日期：1978-11-01 00:00:00

abstract：:Two siblings presented with a new phenotype consisting of fatal progressive macrocephaly and hypertrophic cardiomyopathy. Onset of symptoms started in both patients at the end of the first month of life with massive brain swelling causing macrocephaly and evolving to extensive brain destruction. Light microscopy of th...

journal_title：Annals of neurology

authors： Dionisi-Vici C,Ruitenbeek W,Fariello G,Bentlage H,Wanders RJ,Schägger H,Bosman C,Piantadosi C,Sabetta G,Bertini E

更新日期：1997-10-01 00:00:00

abstract：:Electroencephalographic (EEG) and evoked potential data were recorded during behavioral testing from 8 dyslexic and 10 normal boys aged 9 to 11 years. Topographic mapping of their brain electrical activity revealed four discrete regions of difference between the two groups involving both hemispheres, left more than ri...

journal_title：Annals of neurology

authors： Duffy FH,Denckla MB,Bartels PH,Sandini G

更新日期：1980-05-01 00:00:00

abstract：:Detrusor hyperreflexia is a relevant clinical symptom for patients suffering from Parkinson's disease. In a series of 16 patients, we demonstrated that subthalamic deep brain stimulation has a significant and urodynamically recordable effect leading to a normalization of pathologically increased bladder sensibility. ...

journal_title：Annals of neurology

authors： Seif C,Herzog J,van der Horst C,Schrader B,Volkmann J,Deuschl G,Juenemann KP,Braun PM

更新日期：2004-01-01 00:00:00

abstract：:Units linked to stimulation of the superior sagittal sinus were identified and recorded from in the trigeminocervical complex of the anesthetized cat. Iontophoresis of glutamate NMDA receptor agonists increased the baseline-firing rate of these neurons. Coejection of sumatriptan, 4991W93, or ergometrine resulted in a ...

journal_title：Annals of neurology

authors： Goadsby PJ,Akerman S,Storer RJ

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:Creatine kinase (CK) levels are increased on dried blood spots in newborns related to the birthing process. As a marker for newborn screening, CK in Duchenne muscular dystrophy (DMD) results in false-positive testing. In this report, we introduce a 2-tier system using the dried blood spot to first assess CK w...

journal_title：Annals of neurology

authors： Mendell JR,Shilling C,Leslie ND,Flanigan KM,al-Dahhak R,Gastier-Foster J,Kneile K,Dunn DM,Duval B,Aoyagi A,Hamil C,Mahmoud M,Roush K,Bird L,Rankin C,Lilly H,Street N,Chandrasekar R,Weiss RB

更新日期：2012-03-01 00:00:00

abstract：:A 65-year-old woman with normal pressure hydrocephalus experienced improved gait and hydrocephalus following surgical resection of a cauda equina neurinoma. Fibrinogen, detected in the cerebrospinal fluid, may be involved in the pathophysiological process of normal pressure hydrocephalus. ...

journal_title：Annals of neurology

authors： Ohta K,Gotoh F,Amano T,Obara K

更新日期：1990-04-01 00:00:00

abstract：:A case-control study was performed to determine the possible roles of various environmental factors, prior illnesses, drug use, and personal habits in the development of Alzheimer's disease. Such information was collected from 40 patients with onset of dementia prior to age 70 and from 80 community control subjects ma...

journal_title：Annals of neurology

authors： Heyman A,Wilkinson WE,Stafford JA,Helms MJ,Sigmon AH,Weinberg T

更新日期：1984-04-01 00:00:00

abstract：:Inborn errors of urea synthesis can present in the newborn period as a catastrophic illness or later in childhood or adulthood with an indolent course punctuated by hyperammonemic episodes. Because symptoms mimic other neuropsychiatric disorders, it is common for there to be a delay in diagnosis, often with dire conse...

journal_title：Annals of neurology

authors： Batshaw ML

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:The UCHL-1 gene is widely cited as a susceptibility factor for sporadic Parkinson's disease (PD). The strongest evidence comes from a meta-analysis of small studies that reported the S18Y polymorphism as protective against PD, after pooling studies of white and Asian subjects. Here, we present data that chall...

journal_title：Annals of neurology

authors： Healy DG,Abou-Sleiman PM,Casas JP,Ahmadi KR,Lynch T,Gandhi S,Muqit MM,Foltynie T,Barker R,Bhatia KP,Quinn NP,Lees AJ,Gibson JM,Holton JL,Revesz T,Goldstein DB,Wood NW

更新日期：2006-04-01 00:00:00

abstract：:Female patients experience substantial neuroprotection after experimental stroke compared with male patients, a finding attributed to the protective effects of gonadal hormones. This study examined the response of male- and female-derived organotypic hippocampal slices to oxidative and excitotoxic injury. Both oxygen ...

journal_title：Annals of neurology

authors： Li H,Pin S,Zeng Z,Wang MM,Andreasson KA,McCullough LD

更新日期：2005-08-01 00:00:00

abstract：:Recently, variant mRNA transcripts for the astroglial glutamate transporter EAAT2 have been detected in brain tissues of 60% of patients with sporadic amyotrophic lateral sclerosis (SALS). We have tested the hypothesis that the gene for EAAT2 may be defective in some ALS cases. In 16 familial ALS (FALS) pedigrees with...

journal_title：Annals of neurology

authors： Aoki M,Lin CL,Rothstein JD,Geller BA,Hosler BA,Munsat TL,Horvitz HR,Brown RH Jr

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:To design a new class of selective neuronal nitric oxide synthase (NOS) inhibitors, and demonstrate that administration in a rabbit model for cerebral palsy (CP) prevents hypoxia-ischemia-induced deaths and reduces the number of newborn kits exhibiting signs of CP. METHODS:We used a novel computer-based drug...

journal_title：Annals of neurology

authors： Ji H,Tan S,Igarashi J,Li H,Derrick M,Martásek P,Roman LJ,Vásquez-Vivar J,Poulos TL,Silverman RB

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Brain-computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene and ameliorate their effects in disease states. Here, we provide proof-of-principle of this approach by using a BCI to interpret pathological brain activity in patients with advanced Parkinson d...

journal_title：Annals of neurology

authors： Little S,Pogosyan A,Neal S,Zavala B,Zrinzo L,Hariz M,Foltynie T,Limousin P,Ashkan K,FitzGerald J,Green AL,Aziz TZ,Brown P

更新日期：2013-09-01 00:00:00

abstract：:This paper attempts to place into perspective the present state of clinical investigation with PET in neurology. To this end we briefly review the work of the neurology group of the MRC Cyclotron Unit at Hammersmith Hospital, by reference to studies performed in normal subjects and in patients with cerebrovascular dis...

journal_title：Annals of neurology

authors： Frackowiak RS,Wise RJ,Gibbs JM,Jones T

更新日期：1984-01-01 00:00:00

abstract：:A brief description is given of neurofibrillary changes of the paired helical filament type in a variety of chronic neurological diseases. These include subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Down syndrome, Hallervorden-Spatz disease, and lipofuscinosis. In these conditions, with...

journal_title：Annals of neurology

authors： Wisniewski K,Jervis GA,Moretz RC,Wisniewski HM

更新日期：1979-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is characterized by patchy accumulations of inflammatory cells combined with demyelination. There are mononuclear cells in blood and cerebrospinal fluid of patients with MS that produce interferon-gamma and interleukin-4 in response to myelin basic protein (MBP) and proteolipid protein (PLP). H...

journal_title：Annals of neurology

authors： Link J,Fredrikson S,Söderström M,Olsson T,Höjeberg B,Ljungdahl A,Link H

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Deletions of CACNA1A, encoding the α1 subunit of CaV 2.1 channels, cause epilepsy with ataxia in humans. Whereas the deletion of Cacna1a in γ-aminobutyric acidergic (GABAergic) interneurons (INs) derived from the medial ganglionic eminence (MGE) impairs cortical inhibition and causes generalized seizures in N...

journal_title：Annals of neurology

authors： Jiang X,Lupien-Meilleur A,Tazerart S,Lachance M,Samarova E,Araya R,Lacaille JC,Rossignol E

更新日期：2018-09-01 00:00:00