Serious renal impairment occurs rarely with use of tenofovir DF.

Abstract:

PURPOSE:The purpose of this study was to evaluate the short-term effects (up to 6 months) of tenofovir disoproxil fumarate (DF) use on renal function in patients being treated for HIV-1 infection. METHOD:The charts of 447 HIV-1-infected patients who received at least three months of tenofovir DF treatment were reviewed. Data collected included demographics, concurrent antiretrovirals, other concurrent medications, CD4 counts and HIV-1 viral loads, and serum creatinine values while on tenofovir DF. Data collection was truncated at 6 months. RESULTS:Baseline serum creatinine (SCr) was 1.0 mg/dL, with a calculated creatinine clearance (CLCr) of 95.2 mL/min (using the Cockroft-Gault equation). There was no significant change in SCr or CLCr at 12 weeks (1.1 mg/dL and 92.7 mL/min, respectively) or 24 weeks (1.1 mg/dL and 92.9 mL/min, respectively). All three patients with grade 2 increases in SCr had other medical reasons for an increased SCr (one patient each had indinavir-associated nephrolithiasis, lactic acidosis, and pancreatitis). No patients experienced any complications from these increases in SCr. CONCLUSION:Increases in SCr and CLCr within the first 6 months of tenofovir DF therapy were rare. Although no clinical nephrotoxicity was observed, continued observation of renal function is warranted in patients predisposed to renal impairment.

journal_name

HIV Clin Trials

journal_title

HIV clinical trials

authors

Scott JD,Wolfe PR,Bolan RK,Guyer B

doi

10.1310/2taj-qpd1-tyae-qak5

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

55-8

issue

2

eissn

1528-4336

issn

1945-5771

pii

2TAJQPD1TYAEQAK5

journal_volume

7

pub_type

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2011-11-01 00:00:00