Endometrial preparation for in vitro oocyte maturation: early use of estrogen increases endometrial tissue and requires lower daily dosage: a cross over trial in 'mock' cycles.

Abstract:

PURPOSE:Determine if estrogen used since the beginning of the menstrual flow could improve endometrial tissue compared to standard endometrial preparation for in vitro maturation cycles. METHODS:Twenty polycystic ovary syndrome women were submitted to two estrogen therapy schedules: standard schedule; estrogen began on the day of planned egg retrieval (dosage was based on endometrial thickness); and long schedule; estrogen began on the first day of menstruation. No oocyte retrieval or embryo transfer was performed. Three-dimensional ultrasound was performed on the day of planned egg retrieval and one week later for endometrial evaluation. RESULTS:A higher endometrial thickness and volume was found in long schedule on both evaluations. The number of patients that have used 10 mg/day of estradiol was significant higher in the standard schedule (65%x0%). No other significant difference was found. CONCLUSIONS:The early use of estrogen improves endometrial tissue and requires lower daily dosage.

journal_name

J Assist Reprod Genet

authors

Martins Wde P,dos Reis RM,Ferriani RA,de Araújo CH,Nastri CO,Filho FM

doi

10.1007/s10815-006-9042-4

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

241-6

issue

5

eissn

1058-0468

issn

1573-7330

journal_volume

23

pub_type

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