Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis.

abstract：RATIONALE:Long-term intermittent hypoxia (LTIH) exposure in adult mice, modeling oxygenation patterns of moderate-severe obstructive sleep apnea, results in lasting hypersomnolence and is associated with nitration and oxidation injuries in many brain regions, including wake-active regions. OBJECTIVES:We sought to dete...

journal_title：American journal of respiratory and critical care medicine

authors： Zhan G,Fenik P,Pratico D,Veasey SC

更新日期：2005-06-15 00:00:00

abstract：RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

journal_title：American journal of respiratory and critical care medicine

authors： Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

更新日期：2019-02-15 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：RATIONALE:The impact of asthma on chronic lung function deficits is well known. However, there has been little study of ethnic differences in these asthma-associated deficits. OBJECTIVES:To examine whether there are ethnic differences in the effects of asthma on children's lung function. METHODS:We evaluated the impa...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,McConnell R,Gilliland F,Berhane K

更新日期：2011-03-01 00:00:00

abstract：:This study aimed to estimate exposure-response relationships for mesothelioma and environmental exposure to crocidolite. All 4,659 former residents of Wittenoom, Western Australia (WA) who lived there between 1943 and 1993 for at least 1 mo and were not directly employed in the crocidolite industry, were followed-up t...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen J,de Klerk NH,Musk AW,Hobbs MS

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:North American occupational health programs that switched from the tuberculin skin test (TST) to IFN-γ release assays for latent tuberculosis screening are reporting challenges with interpretation of serial testing results in healthcare workers (HCWs). However, limited data exist on the reproducibility of ser...

journal_title：American journal of respiratory and critical care medicine

authors： Slater ML,Welland G,Pai M,Parsonnet J,Banaei N

更新日期：2013-10-15 00:00:00

abstract：:Despite several codes of research ethics, the issuance of comprehensive rules regarding informed consent by governmental agencies, and numerous writings on the subject of informed consent, many commentators still question the quality of the informed consent process in clinical research. A major concern is that investi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman HJ

更新日期：1996-09-01 00:00:00

abstract：:Measurement of cardiac output using thermodilution technique in mechanically ventilated patients is associated with significant morbidity. The goal of the present study was to assess the validity of cardiac output measurement using transesophageal Doppler in critically ill patients. Forty-six patients from three diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Valtier B,Cholley BP,Belot JP,de la Coussaye JE,Mateo J,Payen DM

更新日期：1998-07-01 00:00:00

abstract：:This study examines hemodialysis clearances of isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB). Seven chronic hemodialysis patients were studied. Six were given single oral doses (INH 300 mg, RIF 600 mg, PZA 1000 mg, and EMB 25 mg/kg) 2 h before hemodialysis (Cobe Centrysystem 3 hemodialysis ...

journal_title：American journal of respiratory and critical care medicine

authors： Malone RS,Fish DN,Spiegel DM,Childs JM,Peloquin CA

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:Congenital central hypoventilation syndrome (CCHS) is a genetic disorder mainly characterized by failure of automatic control of breathing, causing alveolar hypoventilation. Little is known regarding cough in CCHS. Parental reports indicate that patients cough normally during airway infections; however, previ...

journal_title：American journal of respiratory and critical care medicine

authors： Lavorini F,Fontana GA,Pantaleo T,Geri P,Piumelli R,Pistolesi M,Widdicombe J

更新日期：2007-10-15 00:00:00

abstract：:The frequency and determinants of exogenous reinfection and of endogenous reactivation of tuberculosis in patients previously treated are poorly understood. In Gran Canaria Island, Spain, between 1991 and 1996, 962 tuberculosis cases were confirmed by culture. Drug susceptibility testing was performed on available bac...

journal_title：American journal of respiratory and critical care medicine

authors： Caminero JA,Pena MJ,Campos-Herrero MI,Rodríguez JC,Afonso O,Martin C,Pavón JM,Torres MJ,Burgos M,Cabrera P,Small PM,Enarson DA

更新日期：2001-03-01 00:00:00

abstract：:Levels of oleic acid (OA) are elevated in plasma and bronchoalveolar lavage fluids of patients with acute respiratory distress syndrome (ARDS). OA is also widely used to provoke edema, by unknown mechanisms, in experimental models of ARDS. We investigated the impact of intravascularly applied OA on epithelial lining f...

journal_title：American journal of respiratory and critical care medicine

authors： Vadász I,Morty RE,Kohstall MG,Olschewski A,Grimminger F,Seeger W,Ghofrani HA

更新日期：2005-03-01 00:00:00

abstract：RATIONALE:Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES:To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS:We first ide...

journal_title：American journal of respiratory and critical care medicine

authors： Kaiser L,Aubert JD,Pache JC,Deffernez C,Rochat T,Garbino J,Wunderli W,Meylan P,Yerly S,Perrin L,Letovanec I,Nicod L,Tapparel C,Soccal PM

更新日期：2006-12-15 00:00:00

abstract：RATIONALE:Patients of Hispanic origin with cystic fibrosis (CF) are the largest growing minority, representing 8.5% of patients with CF in the United States. No national survival analysis of this group has ever been undertaken. OBJECTIVES:We aimed to determine whether Hispanic ethnicity within the CF population is ass...

journal_title：American journal of respiratory and critical care medicine

authors： Rho J,Ahn C,Gao A,Sawicki GS,Keller A,Jain R

更新日期：2018-10-15 00:00:00

abstract：RATIONALE:Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVE...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson WH,Coakley RD,Button B,Henderson AG,Zeman KL,Alexis NE,Peden DB,Lazarowski ER,Davis CW,Bailey S,Fuller F,Almond M,Qaqish B,Bordonali E,Rubinstein M,Bennett WD,Kesimer M,Boucher RC

更新日期：2015-07-15 00:00:00

abstract：:In a prospective, controlled, and randomized clinical trial, we examined the effects of treatment with vitamin D (1,000 IU/d), calcium (1 g/d), and ethane-1-hydroxy-1,1-diphosphonate (EHDP; 7.5 mg/kg body weight) on vertebral bone mass in fourteen asthmatics undergoing long-term treatment with systemically applied cor...

journal_title：American journal of respiratory and critical care medicine

authors： Worth H,Stammen D,Keck E

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness. Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory ...

journal_title：American journal of respiratory and critical care medicine

authors： Rukhadze I,Fenik VB,Benincasa KE,Price A,Kubin L

更新日期：2010-11-15 00:00:00

abstract：:Calculation of diurnal peak expiratory flow (PEF) variability using values before and after bronchodilator is no longer possible for many asthmatic patients because they now use beta-agonists "as needed" for symptoms rather than regularly. This study assesses the usefulness of a number of alternative PEF indices as ma...

journal_title：American journal of respiratory and critical care medicine

authors： Reddel HK,Salome CM,Peat JK,Woolcock AJ

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:FVC has emerged as a standard primary endpoint in clinical trials evaluating novel therapies for patients with idiopathic pulmonary fibrosis (IPF). However, it has recently been proposed that all-cause mortality or a composite comprised of all-cause mortality and all-cause nonelective hospitalization be adopt...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr,Albera C,Bradford WZ,Costabel U,du Bois RM,Leff JA,Nathan SD,Sahn SA,Valeyre D,Noble PW

更新日期：2014-04-01 00:00:00

abstract：:The present prospective study was designed to determine the prevalence of pleural effusion at approximately 28 days after cardiac surgery and their subsequent course. This consecutive case study included 389 patients; 312 had only coronary artery bypass graft surgery (CABG) surgery, 37 had both valve and CABG surgery,...

journal_title：American journal of respiratory and critical care medicine

authors： Light RW,Rogers JT,Moyers JP,Lee YC,Rodriguez RM,Alford WC Jr,Ball SK,Burrus GR,Coltharp WH,Glassford DM Jr,Hoff SJ,Lea JW 4th,Nesbitt JC,Petracek MR,Starkey TD,Stoney WS,Tedder M

更新日期：2002-12-15 00:00:00

abstract：RATIONALE:5-Hydroxytryptamine (5-HT) is involved in the pathogenesis of allergic airway inflammation (AAI). It is unclear, however, how 5-HT contributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for peripheral 5-HT synthesis. OBJECTIVES:To elucidate the role of TPH1 and the...

journal_title：American journal of respiratory and critical care medicine

authors： Dürk T,Duerschmied D,Müller T,Grimm M,Reuter S,Vieira RP,Ayata K,Cicko S,Sorichter S,Walther DJ,Virchow JC,Taube C,Idzko M

更新日期：2013-03-01 00:00:00

abstract：:The pathophysiology of impaired exercise tolerance in patients with cystic fibrosis (CF) is not completely understood. The objective of this study was to compare exercise ability (at clinical and cellular levels) and resting energy expenditure in female athletes with CF compared with matched control subjects. Sixteen ...

journal_title：American journal of respiratory and critical care medicine

authors： Selvadurai HC,Allen J,Sachinwalla T,Macauley J,Blimkie CJ,Van Asperen PP

更新日期：2003-12-15 00:00:00

abstract：:The incidence of mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in children with intermediate sweat chloride levels is unknown. The results of 2,349 sweat tests performed at two Belgian university hospitals were reviewed. Intermediate chloride concentrations were observed in 98 subjec...

journal_title：American journal of respiratory and critical care medicine

authors： Lebecque P,Leal T,De Boeck C,Jaspers M,Cuppens H,Cassiman JJ

更新日期：2002-03-15 00:00:00

abstract：:Cryptogenic fibrosing alveolitis has been reported to be associated with an increased risk of lung cancer. However, it has recently become apparent that cigarette smoking may be a risk factor for cryptogenic fibrosing alveolitis as well as for lung cancer, and so may confound the association between these conditions. ...

journal_title：American journal of respiratory and critical care medicine

authors： Hubbard R,Venn A,Lewis S,Britton J

更新日期：2000-01-01 00:00:00

abstract：:We derived reference values for slow vital capacity (VC) and flow-volume curve indexes (FVC, FEV(1), and flows) from the 1,185 tracings provided by 1,039 "normal" subjects who participated in one or both cross-sectional surveys of the Po River Delta study in 1980-1982 and in 1988-1991. Definition of "normal" was based...

journal_title：American journal of respiratory and critical care medicine

authors： Pistelli F,Bottai M,Viegi G,Di Pede F,Carrozzi L,Baldacci S,Pedreschi M,Giuntini C

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied. OBJECTIVES:To examine the functional and transcriptional profiles of pa...

journal_title：American journal of respiratory and critical care medicine

authors： Juss JK,House D,Amour A,Begg M,Herre J,Storisteanu DM,Hoenderdos K,Bradley G,Lennon M,Summers C,Hessel EM,Condliffe A,Chilvers ER

更新日期：2016-10-15 00:00:00

abstract：:Four hundred forty-one subjects 34 to 69 yr of age were recruited from a random sample of the community. The sample was biased in favor of men, snorers, and subjects with subjective sleep complaints. They answered a questionnaire and were monitored in their homes for sleep-disordered breathing (SDB). This report conce...

journal_title：American journal of respiratory and critical care medicine

authors： Olson LG,King MT,Hensley MJ,Saunders NA

更新日期：1995-08-01 00:00:00

abstract：:The plasma level of fibrinogen is felt to be an independent risk factor for vascular events. Obstructive sleep apnea (OSA) has a high prevalence in patients with stroke and may also be an independent risk factor. The aim of our study was to determine the association between OSA and plasma levels of fibrinogen in patie...

journal_title：American journal of respiratory and critical care medicine

authors： Wessendorf TE,Thilmann AF,Wang YM,Schreiber A,Konietzko N,Teschler H

更新日期：2000-12-01 00:00:00

abstract：:The severity of asthma can be graded from mild intermittent to severe persistent. Airway inflammation is a feature of persistent asthma. We compared several markers of inflammation in mucosal biopsies and bronchoalveolar lavage fluid (BAL fluid) from 12 healthy control subjects, 24 patients with intermittent asthma, a...

journal_title：American journal of respiratory and critical care medicine

authors： Vignola AM,Chanez P,Campbell AM,Souques F,Lebel B,Enander I,Bousquet J

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Comorbidities contribute to disease severity and mortality in patients with chronic obstructive pulmonary disease (COPD). Comorbidities have been studied individually and were mostly based on self-reports. The coexistence of objectively identified comorbidities and the role of low-grade systemic inflammation ...

journal_title：American journal of respiratory and critical care medicine

authors： Vanfleteren LE,Spruit MA,Groenen M,Gaffron S,van Empel VP,Bruijnzeel PL,Rutten EP,Op 't Roodt J,Wouters EF,Franssen FM

更新日期：2013-04-01 00:00:00