Abstract:
OBJECTIVE:The American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for management of ASC-H is colposcopic examination followed by biopsy. HPV testing (HPVT) is recommended after a negative biopsy result. More definitive interpretation of ASC-H could prevent discomfort and minimize the cost. The purpose of this study was to evaluate association of various cytomorphological patterns of ASC-H with various clinical scenarios. METHODS:We reviewed SurePath (TriPath Imaging, Inc. Burlington, NC, USA) cervical smears interpreted as ASC-H in 161 women (mean age, 37 {15 to 78} years), over 24 months (2002 to 2003). HPVT (Digene, Hybrid Capture II HPV test, Digene Corporation, Gaithersburg, MD, USA) was performed in 20% of cases (33/161) and biopsy results were available in 54 cases (19 with and 35 without HPVT). RESULTS:HPVT was positive in 64% (21/33) cases, and negative in 36% (12/33) cases. In the follow-up biopsies of 71% (15/21) of cases with positive HPVT, 27% showed HPV changes or CIN1, 27% showed CIN2-3, and 46% were negative for epithelial abnormality. Follow-up biopsies from cases with negative HPVT (33%, 4/12 cases), 8% showed CIN1 and 25% were negative for any epithelial abnormality. Six cytomorphological patterns of ASC-H correlated with different clinical categories in relation to HPVT and biopsy results. 35% (19 out of 54 ASC-H cases in which biopsy results were available) could be interpreted definitively as HSIL by cytopathology, 11% (6/54) cases as LSIL with cyanophilic atypical parakeratotic pattern, and 31% (17/54) cases as reactive, with HPV status. The interpretation had to be continued as ASC-H in 22% (12/54) cases. CONCLUSION:ASC-H demonstrated a spectrum of cytomorphological patterns. Some of these patterns in liquid-based cervical smears may be more specifically interpreted as LSIL, HSIL, or benign if HPV status is known.
journal_name
Cytojournaljournal_title
CytoJournalauthors
Chivukula M,Shidham VBdoi
10.1186/1742-6413-3-14subject
Has Abstractpub_date
2006-05-10 00:00:00pages
14eissn
0974-5963issn
1742-6413pii
1742-6413-3-14journal_volume
3pub_type
杂志文章相关文献
CytoJournal文献大全abstract::To analyze the impact of using a hand held fan to speed the air-drying process during immediate adequacy evaluation of Fine Needle Aspirations. The effect on turn around time and staining quality is evaluated. Two mirror image air-dried smears for each pass were prepared. One was subjected to a small hand-held fan wit...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-3-12
更新日期:2006-04-19 00:00:00
abstract:Background:Epidermal growth factor receptor mutation-positive (EGFR-p) lung adenocarcinomas are sensitive to tyrosine kinase inhibitors. Although histopathological subtype is an independent predictor of mutation status, there is a paucity of data on the cytomorphological features correlating with the EGFR mutation stat...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/cytojournal.cytojournal_45_17
更新日期:2018-04-02 00:00:00
abstract:Background:Leishmaniasis is the prevalent in tropical and subtropical regions of the world. Demonstration of Leishman-Donovan (LD) bodies in the bone marrow aspirates (BMA) is vital to diagnosis of visceral leishmaniasis (VL). In the present study, we studied the clinicohematological parameters encountered in VL and co...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/cytojournal.cytojournal_38_17
更新日期:2018-08-27 00:00:00
abstract:BACKGROUND:Self-collection of anorectal swab specimens could greatly facilitate the completion of prerequisite studies and future implementation of anal cancer screening among men who have sex with men (MSM). We therefore compared self- versus clinician- collection procedures with respect to specimen adequacy for cytol...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-3-4
更新日期:2006-03-20 00:00:00
abstract:BACKGROUND:Desmoplastic melanoma is a variant of malignant melanoma that can range in appearance from sarcomatoid to scar-like. Cytomorphology of desmoplastic melanoma has been previously described on conventional smears; however, to our knowledge, detailed cytomorphology on ThinPrep has so far not been described. Here...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-4-18
更新日期:2007-09-19 00:00:00
abstract::Urachal carcinoma is rare comprising less than 1% of all bladder carcinomas. Metastases of urachal carcinoma have been reported to meninges, brain, ovary, lung, and maxilla. Cytologic features of metastatic urachal carcinoma have not been previously reported. We present a case of metastatic urachal adenocarcinoma in b...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.106684
更新日期:2013-01-31 00:00:00
abstract::Synovial sarcoma (SS) is a rare soft tissue tumor, commonly arising in para-articular areas of extremities, but can also present in the head and neck area. However, primary SS of the thyroid gland is an extremely rare tumor which has been reported only five times in previous English literatures. This report presents f...
journal_title:CytoJournal
pub_type:
doi:10.4103/cytojournal.cytojournal_14_17
更新日期:2017-10-12 00:00:00
abstract::BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of these tumors can be difficult because they show morphological features quite similar to other small round blue cells tumors. We described four cases of DSRCT with cytological sampling: one obt...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-2-6
更新日期:2005-03-18 00:00:00
abstract:BACKGROUND:The Paris System for Reporting Urinary Cytology represents a significant improvement in classification of urinary specimens. The system acknowledges the difficulty in cytologically diagnosing low-grade urothelial carcinomas and has developed categories to deal with this issue. The system uses six categories:...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/cytojournal.cytojournal_12_17
更新日期:2017-07-24 00:00:00
abstract:BACKGROUND:Molecular techniques are relevant to modern cytopathology, but their implementation is difficult without molecular expertise and infrastructure. The assessment of KRAS mutational status on cytological preparations may be useful either to refine uncertain diagnoses on pancreatic aspirates or to yield predicti...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.200936
更新日期:2017-02-24 00:00:00
abstract:Objective:Squamous cell carcinoma (SCC) rarely causes malignant effusions. Distinguishing between SCC and adenocarcinoma in effusion cytology can be a challenge. p63 and p40 have been frequently used to support squamous cell differentiation in both histological and cytological specimens. However, similar results in cyt...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.25259/Cytojournal_78_2019
更新日期:2020-06-08 00:00:00
abstract::Cell-blocks are paraffin-embedded versions of cytology specimens comparable to the formalin-fixed paraffin-embedded (FFPE) tissue from surgical pathology specimens. They allow various elective ancillary studies on a variety of specimens with enhanced cytopathologic interpretation, including opportunity to perform mole...
journal_title:CytoJournal
pub_type: 杂志文章,评审
doi:10.4103/cytojournal.cytojournal_20_19
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:Next-generation sequencing (NGS) with a multi-gene panel is now available for patients with lung adenocarcinoma, but the performance characteristics and clinical utility of this testing are not well-described. We present the results of an extended 467 gene panel in a series of advanced, highly selected nonsm...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.202602
更新日期:2017-03-20 00:00:00
abstract::Breast augmentation with implantation represents a challenge for subsequent radiographic imaging and pathological sampling. Fine-needle aspiration biopsy (FNAB) is an excellent technique to sample suspicious lesions that are adjacent to fragile implants. We report a case of a 51-year-old woman with breast implants pre...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.149844
更新日期:2015-01-22 00:00:00
abstract:BACKGROUND:To evaluate and compare the role of Ziehl-Neelsen (ZN) staining and mycobacterial culture in diagnosis of tuberculous lymphadenitis. MATERIALS AND METHODS:A total of 56 fine needle aspirations (FNAs) from patients who were clinically suspected to have tuberculous lymphadenitis were included. Acid-fast Bacil...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.187070
更新日期:2016-07-27 00:00:00
abstract::Solitary tracheobronchial papilloma (STBP) is a rare benign tumor that primarily involves the tracheobronchial tree. Human papilloma virus (HPV) infection is associated with dysplasia and a high risk of carcinoma in these lesions. The cytomorphology of STBP is not well established in the literature. Our aim is to char...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.77286
更新日期:2011-03-03 00:00:00
abstract:BACKGROUND:Multiple Myeloma presenting as a pleural effusion is extremely rare. It is usually a late complication and is associated with a poor prognosis. CASE PRESENTATION:A 40-year-old male presented with dyspnea and fever of six months duration. Clinical diagnosis of pulmonary tuberculosis was considered. X-ray che...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-4-17
更新日期:2007-09-07 00:00:00
abstract::Paragangliomas (PGLs) are uncommon tumors. Although PGLs are known to occur in the head and neck region, especially the carotid body, middle ear, and larynx, involvement of the parotid glands has not been reported. In this article, we report the fine needle aspiration features of tumor in an unusual location, presenti...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.105119
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Pancreatic neuroendocrine tumors (PNETs) are rare tumors of the pancreas, which are increasingly diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). In this retrospective study, we assessed the performance of EUS-FNA in diagnosing PNETs. MATERIALS AND METHODS:We identified 48 cases o...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.112648
更新日期:2013-05-29 00:00:00
abstract:BACKGROUND:The overall malignancy rate for the thyroid fine-needle aspiration (FNA) diagnosed as atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) ranges from 5% to 30%. In this study, we present our institutional experience with thyroid nodules diagnosed as AUS/FLUS and furt...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.139725
更新日期:2014-08-28 00:00:00
abstract:INTRODUCTION:The most common site for the metastasis of papillary carcinoma of the thyroid (PTC) is regional lymph nodes. Ultrasound (US) imaging may identify abnormal appearing lymph nodes, suspicious for PTC recurrence. Although fine needle aspiration biopsy (FNAB) of abnormal lymph nodes is often diagnostic of recur...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.1186/1742-6413-5-1
更新日期:2008-01-31 00:00:00
abstract:BACKGROUND:Granular cell tumors (GCT) formerly known as Abrikossoff tumor or granular cell myoblastoma, are rare neoplasms encountered in the fine needle aspiration (FNA) service. Named because of their highly granular cytoplasm which is invariably positive for the S-100 antibody, the classic GCT is thought to be of ne...
journal_title:CytoJournal
pub_type: 杂志文章,评审
doi:10.4103/1742-6413.143304
更新日期:2014-10-21 00:00:00
abstract::[This corrects the article on p. 15 in vol. 13, PMID: 27563338.]. ...
journal_title:CytoJournal
pub_type: 已发布勘误
doi:10.4103/1742-6413.192192
更新日期:2016-10-13 00:00:00
abstract:BACKGROUND:Hashimoto's thyroiditis (HT) is an autoimmune disease and it is more prevalent in Asians. The incidence of HT seems to be increasing in the recent times. It is one of the most common cause of hypothyroidism. The purpose of this study is to review the cytomorphologic spectrum of HT and correlate it with clini...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.131741
更新日期:2014-04-29 00:00:00
abstract:BACKGROUND:Tubercular involvement of the liver is uncommon, but is a serious consideration in differential diagnosis of granulomatous conditions, especially in endemic regions like India. OBJECTIVE:To assess the role of polymerase chain reaction (PCR) done on archival cytological material in diagnosing tuberculosis (T...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.198815
更新日期:2017-01-20 00:00:00
abstract:BACKGROUND:Research and publications are critical to advancements in the quality of healthcare delivery. This article attempts to highlight the prospects and challenges of fine needle aspiration (FNA) cytology as a tool for research in Nigeria. MATERIALS AND METHODS:Data available in local and international bibliograp...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.82277
更新日期:2011-01-01 00:00:00
abstract::Visceral leishmaniasis (VL), also known as kala-azar, is a life-threatening systemic disease caused by the obligate intracellular protozoan, Leishmania, and transmitted to humans by the female phlebotomine sand fly (Phlebotomus argentipes). The disease is fatal, if left untreated. We report a case of a patient clinica...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.205312
更新日期:2017-04-28 00:00:00
abstract:BACKGROUND:Endobronchial ultrasound-guided transbronchial fine-needle aspiration is a minimally invasive technique for diagnosis of mediastinal lesions. Although most studies have reported the utility of EBUS-FNA in malignancy, its use has been extended to the benign conditions as well. OBJECTIVE:To evaluate the diagn...
journal_title:CytoJournal
pub_type: 杂志文章
doi:10.4103/1742-6413.165947
更新日期:2015-09-22 00:00:00
abstract::Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystoure...
journal_title:CytoJournal
pub_type:
doi:10.4103/1742-6413.95528
更新日期:2012-01-01 00:00:00
abstract::In recent times, the diagnosis of breast lesions has mostly become dependent on core needle biopsies (CNBs) with a gradual reduction in the rate of performing fine-needle aspiration cytology (FNAC). Both the procedures have their pros and cons and outsmart each other taking into account different parameters. Both the ...
journal_title:CytoJournal
pub_type: 杂志文章,评审
doi:10.4103/1742-6413.189637
更新日期:2016-08-31 00:00:00