Abstract:
:Feldman, L. A. (Baylor University College of Medicine, Houston, Tex.), J. L. Melnick, and F. Rapp. Influence of SV40 genome on the replication of an adenovirus-SV40 "hybrid" population. J. Bacteriol. 90:778-782. 1965.-Replication of a type 7 adenovirus-SV40 hybrid population in primary African green monkey kidney cells was accompanied by the formation of SV40 tumor antigen, adenovirus antigens, and cytopathic changes characteristic of adenovirus infection. Prior infection of the cultures with SV40 stimulated replication of nonintegrated adenovirus 7 but did not enhance the replication of the hybrid virus. These results suggest that the population of the adenovirus-SV40 hybrid studied contains many particles carrying SV40 information. Replication of SV40 virus was not enhanced by co-infection with nonintegrated adenovirus 7 or with the adenovirus-SV40 hybrid. Cytosine arabinoside strongly inhibited replication of the adenovirus-SV40 hybrid population in African green monkey kidney cells. Enhanced replication of nonintegrated adenovirus 7 by SV40 was blocked by cytosine arabinoside; this block could be reversed by 2-deoxycytidine or deoxycytidine triphosphate.
journal_name
J Bacterioljournal_title
Journal of bacteriologyauthors
Feldman LA,Melnick JL,Rapp Fdoi
10.1128/JB.90.3.778-782.1965keywords:
subject
Has Abstractpub_date
1965-09-01 00:00:00pages
778-82issue
3eissn
0021-9193issn
1098-5530journal_volume
90pub_type
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更新日期:2018-08-10 00:00:00
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更新日期:2016-05-13 00:00:00
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更新日期:1970-10-01 00:00:00