Influence of SV40 Genome on the Replication of an Adenovirus-SV40 "Hybrid" Population.

Abstract:

:Feldman, L. A. (Baylor University College of Medicine, Houston, Tex.), J. L. Melnick, and F. Rapp. Influence of SV40 genome on the replication of an adenovirus-SV40 "hybrid" population. J. Bacteriol. 90:778-782. 1965.-Replication of a type 7 adenovirus-SV40 hybrid population in primary African green monkey kidney cells was accompanied by the formation of SV40 tumor antigen, adenovirus antigens, and cytopathic changes characteristic of adenovirus infection. Prior infection of the cultures with SV40 stimulated replication of nonintegrated adenovirus 7 but did not enhance the replication of the hybrid virus. These results suggest that the population of the adenovirus-SV40 hybrid studied contains many particles carrying SV40 information. Replication of SV40 virus was not enhanced by co-infection with nonintegrated adenovirus 7 or with the adenovirus-SV40 hybrid. Cytosine arabinoside strongly inhibited replication of the adenovirus-SV40 hybrid population in African green monkey kidney cells. Enhanced replication of nonintegrated adenovirus 7 by SV40 was blocked by cytosine arabinoside; this block could be reversed by 2-deoxycytidine or deoxycytidine triphosphate.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Feldman LA,Melnick JL,Rapp F

doi

10.1128/JB.90.3.778-782.1965

keywords:

subject

Has Abstract

pub_date

1965-09-01 00:00:00

pages

778-82

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

90

pub_type

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