PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis.

Abstract:

:We have cloned a lytic enzyme, PlyPH, with a specific lytic effect on Bacillus anthracis strains. PlyPH remains active between pH 4 and 10.5, and a single dose rescued a significant percentage of mice infected intraperitoneally with an attenuated B. anthracis strain. We propose PlyPH as a novel therapeutic agent.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Yoong P,Schuch R,Nelson D,Fischetti VA

doi

10.1128/JB.188.7.2711-2714.2006

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

2711-4

issue

7

eissn

0021-9193

issn

1098-5530

pii

188/7/2711

journal_volume

188

pub_type

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