Serological pattern "anti-HBc alone": characterization of 552 individuals and clinical significance.

Abstract:

AIM:To investigate the prevalence and clinical significance of "anti-HBc alone" in an unselected population of patients and employees of a university hospital in southern Germany. METHODS:All individuals with the pattern "anti-HBc alone" were registered over a time span of 82 mo. HBV-DNA was measured in serum and liver samples, and clinical charts were reviewed. RESULTS:Five hundred and fifty two individuals were "anti-HBc alone" (of 3004 anti-HBc positive individuals; 18.4%), and this pattern affected males (20.5%) more often than females (15.3%; P<0.001). HBV-DNA was detected in serum of 44 of 545 "anti-HBc alone" individuals (8.1%), and in paraffin embedded liver tissue in 16 of 39 patients tested (41.0%). There was no association between the detection of HBV genomes and the presence of biochemical, ultrasonic or histological signs of liver damage. Thirty-eight "anti-HBc alone" patients with cirrhosis or primary liver carcinoma had at least one additional risk factor. HCV-coinfection was present in 20.4% of all individuals with "anti-HBc alone" and was the only factor associated with a worse clinical outcome. CONCLUSION:In an HBV low prevalence area, no evidence is found that HBV alone causes severe liver damage in individuals with "anti-HBc alone". Recommendations for the management of these individuals are given.

journal_name

World J Gastroenterol

authors

Knöll A,Hartmann A,Hamoshi H,Weislmaier K,Jilg W

doi

10.3748/wjg.v12.i8.1255

keywords:

subject

Has Abstract

pub_date

2006-02-28 00:00:00

pages

1255-60

issue

8

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

杂志文章
  • Diet and microbiota in inflammatory bowel disease: The gut in disharmony.

    abstract::Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i12.2124

    authors: Rapozo DC,Bernardazzi C,de Souza HS

    更新日期:2017-03-28 00:00:00

  • Analysis of gene expression profile of pancreatic carcinoma using cDNA microarray.

    abstract:AIM:To identify new diagnostic markers and drug targets, the gene expression profiles of pancreatic cancer were compared with that of adjacent normal tissues utilizing cDNA microarray analysis. METHODS:cDNA probes were prepared by labeling mRNA from samples of six pancreatic carcinoma tissues with Cy5-dUTP and mRNA fr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i4.818

    authors: Tan ZJ,Hu XG,Cao GS,Tang Y

    更新日期:2003-04-01 00:00:00

  • Viral blips during long-term treatment with standard or double dose lamivudine in HBe antigen negative chronic hepatitis B.

    abstract:AIM:To evaluate safety and effect on hepatitis B virus (HBV) suppression of a long-term treatment with lamivudine (LAM) at standard (100 mg/d) or double (200 mg/d) dose in chronic hepatitis B. METHODS:This was a case study with matched controls (1:3) in patients with chronic hepatitis B with anti-HBe antibodies. RESU...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v13.i42.5642

    authors: Stornaiuolo G,Stanzione M,Brancaccio G,Cuomo G,Precone V,Di Biase S,Felaco FM,Piccinino F,Gaeta GB

    更新日期:2007-11-14 00:00:00

  • Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease.

    abstract:AIM:To determine serum vitamin D levels and colonic vitamin D receptor (VDR) expression in inflammatory bowel disease (IBD) and non-IBD patients and correlate these with histopathology. METHODS:Puerto Rican IBD (n = 10) and non-IBD (n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i13.3581

    authors: Abreu-Delgado Y,Isidro RA,Torres EA,González A,Cruz ML,Isidro AA,González-Keelan CI,Medero P,Appleyard CB

    更新日期:2016-04-07 00:00:00

  • Intermediate-advanced hepatocellular carcinoma in Argentina: Treatment and survival analysis.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of HCC. AIM:To describe real-life treatments performed in patients with intermediate-advanced HCC before th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.v25.i27.3607

    authors: Piñero F,Marciano S,Fernández N,Silva J,Anders M,Zerega A,Ridruejo E,Romero G,Ameigeiras B,D'Amico C,Gaite L,Bermúdez C,Reggiardo V,Colombato L,Gadano A,Silva M

    更新日期:2019-07-21 00:00:00

  • Transjugular intrahepatic portosystemic shunt with accidental diagnosis of persistence of the left superior vena cava.

    abstract::Transjugular intrahepatic portosystemic shunt (TIPSS) is considered a valid therapeutic option for the treatment of portal hypertension and its complications. The guidelines for this procedure have already been established on the basis of the normal vascular anatomy and of various technical radiological aspects. In so...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i9.1158

    authors: Petridis I,Miraglia R,Marrone G,Gruttadauria S,Luca A,Vizzini GB,Gridelli B

    更新日期:2010-03-07 00:00:00

  • Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles.

    abstract:AIM:To prepare the chitosan-pmEpo nanoparticles and to study their ability for transcellular and paracellular transport across intestinal epithelia by oral administration. METHODS:ICR mice were fed with recombinant plasmid AAV-tetO-CMV-mEpo (containing mEpo gene) or pCMVbeta(containing LacZ gene), whether it was wrapp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i1.112

    authors: Chen J,Yang WL,Li G,Qian J,Xue JL,Fu SK,Lu DR

    更新日期:2004-01-01 00:00:00

  • JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease.

    abstract::The incidence of obesity has dramatically increased in recent years. Consequently, obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem. Therefore, the contribution of adipose tissue to metabolic homeostasis has become a focus of interest. In this review, we discuss th...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v17.i33.3785

    authors: Tarantino G,Caputi A

    更新日期:2011-09-07 00:00:00

  • Prospective randomized controlled trial investigating the type of sutures used during hepatectomy.

    abstract:AIM:To determine whether absorbable sutures or non-absorbable sutures are better in preventing surgical site infection (SSI), in this paper we discuss the results of a randomized clinical trial which examined the type of sutures used during hepatectomy. METHODS:All hepatic resections performed from January 2007 to Nov...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3748/wjg.v17.i18.2338

    authors: Harimoto N,Shirabe K,Abe T,Yukaya T,Tsujita E,Gion T,Kajiyama K,Nagaie T

    更新日期:2011-05-14 00:00:00

  • Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients.

    abstract:AIM:To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness in Chinese patients. METHODS:The resected cancer and adjacent normal tissues (10 cm beyond cancer margins) from 101 consecutive patients with CRC were collected. Fluorescent ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i11.3227

    authors: Li YY,Ge QX,Cao J,Zhou YJ,Du YL,Shen B,Wan YJ,Nie YQ

    更新日期:2016-03-21 00:00:00

  • Malignant extra-gastrointestinal stromal tumor of the pancreas: report of two cases and review of the literature.

    abstract::Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors that arise from the gastrointestinal tract. In rare cases, these tumors are found in intra-abdominal sites unrelated to the gastrointestinal tract, such as the mesentery, omentum and retroperitoneum. However, pancreatic extra-gastrointestinal stromal tumor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i3.863

    authors: Tian YT,Liu H,Shi SS,Xie YB,Xu Q,Zhang JW,Zhao DB,Wang CF,Chen YT

    更新日期:2014-01-21 00:00:00

  • Circulating tumor DNA as a liquid biopsy target for detection of pancreatic cancer.

    abstract::Most pancreatic cancer patients present with advanced metastatic disease, resulting in extremely poor 5-year survival, mainly because of the lack of a reliable modality for early detection and limited therapeutic options for advanced disease. Therefore, there is a need for minimally-invasive diagnostic tools for detec...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i38.8480

    authors: Takai E,Yachida S

    更新日期:2016-10-14 00:00:00

  • Diagnostic efficacy of the Japan Narrow-band-imaging Expert Team and Pit pattern classifications for colorectal lesions: A meta-analysis.

    abstract:BACKGROUND:Pit pattern classification using magnifying chromoendoscopy is the established method for diagnosing colorectal lesions. The Japan Narrow-band-imaging (NBI) Expert Team (JNET) classification is a novel NBI magnifying endoscopic classification that focuses on the vessel, and surface patterns. AIM:To determin...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v26.i40.6279

    authors: Zhang Y,Chen HY,Zhou XL,Pan WS,Zhou XX,Pan HH

    更新日期:2020-10-28 00:00:00

  • Dietary compliance in celiac disease.

    abstract::Celiac disease is an immune-mediated disorder that causes severe architectural disturbance in the small intestinal mucosa of genetically-predisposed individuals. Impaired absorption of multiple nutrients results and diarrhea and weight loss develop. Evidence has accumulated that a strict gluten-free diet can result in...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v23.i15.2635

    authors: Freeman HJ

    更新日期:2017-04-21 00:00:00

  • Optimal initiation of Helicobacter pylori eradication in patients with peptic ulcer bleeding.

    abstract:AIM:To evaluate when Helicobacter pylori (H. pylori) eradication therapy (ET) should be started in patients with peptic ulcer bleeding (PUB). METHODS:Clinical data concerning adults hospitalized with PUB were retrospectively collected and analyzed. Age, sex, type and stage of peptic ulcer, whether endoscopic therapy w...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i8.2497

    authors: Yoon H,Lee DH,Jang ES,Kim J,Shin CM,Park YS,Hwang JH,Kim JW,Jeong SH,Kim N

    更新日期:2015-02-28 00:00:00

  • Treatment of gastric outlet and duodenal obstructions with uncovered expandable metal stents.

    abstract:AIM:To investigate and evaluate the technical feasibility and clinical effectiveness of fluoroscopically guided peroral uncovered expandable metal stent placement to treat gastric outlet and duodenal obstructions. METHODS:Fifteen consecutive patients underwent peroral placement of Wallstent(TM) Enteral Endoprosthesis ...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v13.i40.5376

    authors: Huang Q,Dai DK,Qian XJ,Zhai RY

    更新日期:2007-10-28 00:00:00

  • Role of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer.

    abstract::Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumour-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the role of mi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i35.7951

    authors: da Silva Oliveira KC,Thomaz Araújo TM,Albuquerque CI,Barata GA,Gigek CO,Leal MF,Wisnieski F,Rodrigues Mello Junior FA,Khayat AS,de Assumpção PP,Rodriguez Burbano RM,Smith MC,Calcagno DQ

    更新日期:2016-09-21 00:00:00

  • Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis.

    abstract::Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and rectum. The hallmark clinical symptom of UC is bloody diarrhea. The clinical course is marked by exacerbations and remissions, which may occur spontaneously or in response to treatment changes or intercurr...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i28.9458

    authors: da Silva BC,Lyra AC,Rocha R,Santana GO

    更新日期:2014-07-28 00:00:00

  • Retroperitoneal fibrosis associated with immunoglobulin G4-related disease.

    abstract::Retroperitoneal fibrosis is a rare disease characterized by the development of inflammation and fibrosis in the soft tissues of the retroperitoneum and other abdominal organs. Retroperitoneal fibrosis can be of 2 types: idiopathic and secondary. The recently advocated concept and diagnostic criteria of immunoglobulin ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v19.i1.35

    authors: Fujimori N,Ito T,Igarashi H,Oono T,Nakamura T,Niina Y,Hijioka M,Lee L,Uchida M,Takayanagi R

    更新日期:2013-01-07 00:00:00

  • Microbial dysbiosis in spouses of ulcerative colitis patients: Any clues to disease pathogenesis?

    abstract::A number of alterations have been found within the gut microbial profile of patients with inflammatory bowel diseases when compared with the healthy population; however, it is unclear whether such dysbiosis is the cause or simply the consequence of the disease state. In ulcerative colitis, the environment seems to pla...

    journal_title:World journal of gastroenterology

    pub_type: 评论,社论

    doi:10.3748/wjg.v23.i37.6747

    authors: Sorrentino D

    更新日期:2017-10-07 00:00:00

  • Desperately seeking hepatitis C virus.

    abstract::Spanish investigators described recently the so-called occult hepatitis C virus (HCV) infection, emphasizing the detection of genomic and antigenomic HCV RNA strands in liver and peripheral blood mononuclear cells. Therefore, the persistence of viral replication in occult HCV infection should be considered as a putati...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.14.2946

    authors: Moreno-Otero R

    更新日期:2008-05-14 00:00:00

  • Safety of lamivudine treatment for chronic hepatitis B in early pregnancy.

    abstract:AIM:To evaluate the safety of lamivudine (LAM) treatment for chronic hepatitis B in early pregnancy. METHODS:A total of 92 pregnant women who received LAM treatment either before pregnancy or in early pregnancy were enrolled in this study. All of the pregnant women volunteered to take lamivudine during pregnancy and w...

    journal_title:World journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3748/wjg.v18.i45.6645

    authors: Yi W,Liu M,Cai HD

    更新日期:2012-12-07 00:00:00

  • Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy-flavone on experimental hepatic injury.

    abstract:AIM:To investigate the pharmacological effects of rice flavone (5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D-glucopyranosyloxy-flavone, RF) separated from panicle-differentiating to flowing rice on rat experimental hepatic injury. METHODS:Models of rat acute hepatic injury induced by carbon tetrachloride (CCl(4)) adminis...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i12.1764

    authors: Xu DH,Mei XT,Chen Y,Li YM,Lv JY,Xu SB

    更新日期:2005-03-28 00:00:00

  • alpha,beta-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats.

    abstract:AIM:To study the beneficial effects of triterpene alpha,beta-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS:Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 x 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of alph...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i34.4272

    authors: Melo CM,Carvalho KM,Neves JC,Morais TC,Rao VS,Santos FA,Brito GA,Chaves MH

    更新日期:2010-09-14 00:00:00

  • Relationship between nuclear morphometry, DNA content and resectability of pancreatic cancer.

    abstract:AIM:To investigate the association of nuclear morphometry and DNA content with resectability of pancreatic cancer. METHODS:A total of 36 patients with pancreatic adenocarcinoma were divided into resectable group and unresectable group. The nuclear morphometry and DNA contents of tumor cells were analyzed by IBAS autoi...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i8.1863

    authors: He YC,Peng W,Qiao JG,Cao J,Chen JW

    更新日期:2003-08-01 00:00:00

  • Effect of discounting on estimation of benefits determined by hepatitis C treatment.

    abstract::The combination of either boceprevir or telaprevir with ribavirin and interferon (triple therapy) has been shown to be more effective than ribavirin+interferon (dual therapy) for the treatment of genotype 1 hepatitis C. Since the benefit of these treatments takes place after years, simulation models are needed to pred...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.v18.i23.3032

    authors: Messori A,Fadda V,Maratea D,Trippoli S

    更新日期:2012-06-21 00:00:00

  • Are we giving biologics too late? The case for early versus late use.

    abstract::Corticosteroids and immunomodulators have been the mainstay therapies for Crohn's disease. Corticosteroids are highly effective to control symptoms in the short-term, but they are not effective in maintaining remission, they heal the mucosa in a reduced proportion of cases, and long-time exposure is associated with an...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.5523

    authors: Ricart E,García-Bosch O,Ordás I,Panés J

    更新日期:2008-09-28 00:00:00

  • Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.

    abstract:AIM:To summarize progress in the study of K-ras gene studies in pancreatic cancer and its potential clinical significance in screening test for early detection of pancreatic cancer, and to differentiate pancreatic cancer from chronic pancreatitis in recent decade. METHODS:Literature search (MEDLINE 1986-2003) was perf...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v10.i4.471

    authors: Mu DQ,Peng YS,Xu QJ

    更新日期:2004-02-15 00:00:00

  • Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors.

    abstract::To review the implication of CXCR4 for gastrointestinal cancer, a "Pubmed" analysis was performed in order to evaluate the relevance of CXCR4 and its ligands for gastrointestinal cancers. Search terms applied were "cancer, malignoma, esophageal, gastric, colon, colorectal, hepatic, pancreatic, CXCR4, SDF-1alpha, and S...

    journal_title:World journal of gastroenterology

    pub_type: 社论,评审

    doi:10.3748/wjg.14.4721

    authors: Schimanski CC,Galle PR,Moehler M

    更新日期:2008-08-14 00:00:00

  • Proinflammatory effects and molecular mechanisms of interleukin-17 in intestinal epithelial cell line HT-29.

    abstract:AIM:To evaluate the proinflammatory effects and molecular mechanisms of interleukin (IL)-17 in intestinal epithelial cell line HT-29. METHODS:HT-29 cells were cultured with IL-17, tumor necrosis factor (TNF)-α, or the combination of both IL-17 and TNF-α. Real-time PCR and Western blot were used to measure the gene exp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i47.17924

    authors: Wang YL,Fang M,Wang XM,Liu WY,Zheng YJ,Wu XB,Tao R

    更新日期:2014-12-21 00:00:00