[Acetylsalicylic acid does not alter the mechanoelectrical transduction of mammalian outer hair cells in vitro].

Abstract:

BACKGROUND:High doses of acetylsalicylic acid (ASS) induce tinnitus and hearing loss. This ototoxic side effect of ASS is characterized by a decrease in spontaneous and evoked otoacoustic emissions. A decrease in otoacoustic emissions is found not only in mammals, but also in non-mammalian ears without electromotile outer hair cells. The molecular mechanism underlying ASS ototoxicity seems to be competitive binding to and a block of the motor molecule prestin. In non-mammalian species, ASS ototoxicity is possibly explained by an effect on the hair bundle. RESULTS:The present data from the outer hair cells of the adult guinea pig cochlea show a reduction in the membrane capacitance by maximally 42%, probably as a result of ASS binding competitively to the motor molecule. However, spontaneous and evoked receptor currents were not modulated by ASS. CONCLUSION:The results suggest an influence of ASS on outer hair cell somatic electromotility, without a concomitant effect on hair-bundle function.

journal_name

HNO

journal_title

HNO

authors

Preyer S,Meyer J

doi

10.1007/s00106-005-1358-3

keywords:

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

670-6

issue

9

eissn

0017-6192

issn

1433-0458

journal_volume

54

pub_type

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