Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.

Abstract:

:We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.

journal_name

Nat Med

journal_title

Nature medicine

authors

Cardona K,Korbutt GS,Milas Z,Lyon J,Cano J,Jiang W,Bello-Laborn H,Hacquoil B,Strobert E,Gangappa S,Weber CJ,Pearson TC,Rajotte RV,Larsen CP

doi

10.1038/nm1375

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

304-6

issue

3

eissn

1078-8956

issn

1546-170X

pii

nm1375

journal_volume

12

pub_type

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