Abstract:
:We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in pancreatectomized rhesus macaques. Although porcine islets transplanted into nonimmunosuppressed macaques were rapidly rejected by a process consistent with cellular rejection, recipients treated with a CD28-CD154 costimulation blockade regimen achieved sustained insulin independence (median survival, >140 days) without evidence of porcine endogenous retrovirus dissemination. Thus, neonatal porcine islets represent a promising solution to the crucial supply problem in clinical islet transplantation.
journal_name
Nat Medjournal_title
Nature medicineauthors
Cardona K,Korbutt GS,Milas Z,Lyon J,Cano J,Jiang W,Bello-Laborn H,Hacquoil B,Strobert E,Gangappa S,Weber CJ,Pearson TC,Rajotte RV,Larsen CPdoi
10.1038/nm1375keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
304-6issue
3eissn
1078-8956issn
1546-170Xpii
nm1375journal_volume
12pub_type
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