Abstract:
:One line (strain) of mouse has been selectively bred in our laboratory for 15 generations to exhibit a very high sensitivity to levorphanol-induced analgesia on the hot plate assay (HAR or high antinociceptive response line). Concurrently, a second line (LAR or low antinociceptive response line) has been bred in the opposite direction, i.e., to exhibit a very low sensitivity under the same conditions. This has resulted in a 7-fold difference in sensitivity between HAR and LAR mice as a result of changes in gene frequency. Receptor autoradiographic studies with 3H-DAGO were carried out in the central gray to find receptor populations differing greatly in density between HAR and LAR mice to parallel their in vivo sensitivity differences: such receptors would then be implicated in mediating in vivo analgesia. The caudal portions of the dorsal raphe nucleus (DRN) showed 1.5- to 2-fold differences in density of mu sites, while the periaqueductal gray (PAG) showed relatively small differences. These results strongly suggest that mu receptors in a portion of the DRN are involved in mediating analgesia due to systemically administered opioids in this population of mice.
journal_name
J Addict Disjournal_title
Journal of addictive diseasesauthors
Belknap JK,Laursen SE,Sampson KE,Wilkie Adoi
10.1300/J069v10n01_03keywords:
subject
Has Abstractpub_date
1991-01-01 00:00:00pages
29-44issue
1-2eissn
1055-0887issn
1545-0848journal_volume
10pub_type
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pub_type: 杂志文章,评审
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journal_title:Journal of addictive diseases
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journal_title:Journal of addictive diseases
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journal_title:Journal of addictive diseases
pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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