Activity of glutaraldehyde at low concentrations (less than 2%) against poliovirus and its relevance to gastrointestinal endoscope disinfection procedures.

Abstract:

:The activity of glutaraldehyde (GTA) at low concentrations (less than 2%) against poliovirus was assessed by a suspension procedure. The inactivation kinetics showed that concentrations of less than or equal to 0.10% were effective against purified poliovirus at pH 7.2; a 1 log10 reduction was obtained in 70 min with 0.02% GTA, and a 3 log10 reduction was obtained in 30 min with 0.10% GTA. GTA activity at low concentrations was greatly enhanced at alkaline pH, but was completely abolished at acid pH. In contrast, the inactivation assays on poliovirus RNA showed that it was highly resistant to GTA at concentrations up to 1.0% at pH 7.2. At pH 8.3 a low inactivation was noticed with 1.0% GTA. Our results are of relevance to hospital practice in digestive endoscopy investigations because there has been an increasing tendency to use low concentrations of GTA and very short contact times in disinfection procedures.

journal_name

Appl Environ Microbiol

authors

Bailly JL,Chambon M,Peigue-Lafeuille H,Laveran H,De Champs C,Beytout D

doi

10.1128/AEM.57.4.1156-1160.1991

keywords:

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

1156-60

issue

4

eissn

0099-2240

issn

1098-5336

journal_volume

57

pub_type

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