Abstract:
OBJECTIVE:To describe clinical, radiological, and histopathologic features of diffuse bronchiolar disease due to chronic occult aspiration. PATIENTS AND METHODS:We identified 4 patients encountered from July 2001 to January 2004 who had persistent respiratory symptoms and lung Infiltrates and who were eventually diagnosed by surgical lung biopsy as having diffuse bronchiolar disease due to chronic occult aspiration. Medical records, radiological studies, and histopathologic specimens were reviewed to assess their clinicoradiologic presentation and diagnostic features. RESULTS:The mean age of these 4 patients was 50 years (age range, 41-59 years), and 2 were women. All presented with persistent dyspnea, cough, and lung infiltrates. Three had a history of gastroesophageal reflux, but only 1 had active symptoms. Chest radiography showed interstitial infiltrates, whereas the predominant finding on computed tomography was numerous centrilobular nodules in all patients. Bronchoscopic lung biopsies had been performed in all patients, and the results were nondiagnostic. Surgical lung biopsy specimens revealed diagnostic features that consisted of bronchiolocentric organizing pneumonia with giant cells that contained material consistent with food in all 4 patients. CONCLUSION:Diffuse bronchiolar disease likely represents an underrecognized form of aspiration-related lung disease and may occur in relatively young Individuals without symptoms suggestive of recurrent aspiration. Radiological features associated with this disorder are distinctively different from those seen in aspiration pneumonia.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Barnes TW,Vassallo R,Tazelaar HD,Hartman TE,Ryu JHdoi
10.4065/81.2.172keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
172-6issue
2eissn
0025-6196issn
1942-5546pii
S0025-6196(11)61666-2journal_volume
81pub_type
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journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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doi:
更新日期:1980-12-01 00:00:00
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更新日期:2006-09-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
abstract::The first 100 liver transplantations at the Mayo Clinic were performed in 83 patients, who required a total of 917 patient days in the intensive-care unit (ICU). The mean duration of stay in the ICU was 5.91 days after liver transplantation and 6.15 days for patients who subsequently required readmission to the ICU. D...
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journal_title:Mayo Clinic proceedings
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doi:
更新日期:1977-11-01 00:00:00
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更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00