Bicarbonate supplementation as a preventive way in statins-induced muscle damage.

Abstract:

PURPOSE:The aim of this study was to evaluate the bicarbonate-induced improvement of statins, cerivastatin, simvastatin acid and lovastatin acid -induced apoptosis using rat myoblast cell line (L6) as a model of in vitro skeletal muscle and of cerivastatin-induced muscle damage in vivo study. METHODS:Statin-induced reduction of cell viability and apoptosis was measured by 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) assay and caspase assay. In vivo, we evaluated plasma creatine phosphokinase (CPK) level in cerivastatin-treated rat. RESULTS:Bicarbonate prevented cerivastatin-, simvastatin- acid and lovastatin acid -induced reduction of cell viability, morphological change and caspase activation in L6 cells. Moreover, in the in vivo study, bicarbonate prevented cerivastatin-induced increase in CPK concentrations. CONCLUSIONS:These results from in vitro and in vivo studies support that bicarbonate supplementation prevented statin-induced muscle damage.

journal_name

J Pharm Pharm Sci

authors

Kobayashi M,Kagawa T,Narumi K,Itagaki S,Hirano T,Iseki K

doi

10.18433/j33018

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

1-8

issue

1

issn

1482-1826

journal_volume

11

pub_type

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