Quantification of coagulation factors and inhibitors. Still a special task.

abstract：:Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of cor...

journal_title：Hamostaseologie

authors： Bugger H,Bode C

更新日期：2015-01-01 00:00:00

abstract：:Platelets play a crucial role in haemostasis and several pathophysiological processes. Collagen is a main initiator for platelet activation and aggregation. Given that Wnt signalling negatively regulates platelet function, and IWR-1 (a small molecule inhibitor for Wnt signalling) has the potential of inhibiting collag...

journal_title：Hamostaseologie

authors： Wang W,Lai S,Xiao Z,Yan H,Li Y,Zhang Y,Wu Y,Wang L

更新日期：2019-11-01 00:00:00

abstract：UNLABELLED:With the development of clotting-factors in the seventies the haemophilia patients were released from being handicapped and began to live a quite normal life. Thus, psychosocial counselling did not seem to be necessary. But the impact of HIV-infection to the world of haemophilia was so intense that professio...

journal_title：Hamostaseologie

authors： Schneider MM,Schramm W

更新日期：2010-11-01 00:00:00

abstract：UNLABELLED:An adequate number of qualified haemophilia centres is an essential requirement for effective and cost-efficient haemophilia care. During a reassessment of the delivery of haemophilia care in Germany a broad range of criteria relating to structure and quality of the centres were defined and a questionnaire w...

journal_title：Hamostaseologie

authors： Zimmermann R,Eifrig B,Lenk H,Pollmann H,Scharrer I,Huth-Kühne A

更新日期：2012-01-01 00:00:00

abstract：:This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is pr...

journal_title：Hamostaseologie

authors： Kehrel BE

更新日期：2008-12-01 00:00:00

abstract：:Haemophilic arthropathy is a complex multifactorial disorder that poses significant challenges to both the treating haematologist and arthroplasty surgeon. Its pathogenesis is incompletely understood. Recent literature has concentrated on the toxic effects of iron and the characteristic inflammatory synovitis. Discuss...

journal_title：Hamostaseologie

authors： Wharton R,Austin S,Back D

更新日期：2017-01-01 00:00:00

abstract：:When assessing the quality of clinical trials in intermittent claudication, on principle the same strict biometric and medical standards need to be applied for studies on the effect of walking exercise as for conservative drug treatment studies. However, as demonstrated by a recent review of the Cochrane Collaboration...

journal_title：Hamostaseologie

authors： Amendt K

更新日期：2006-08-01 00:00:00

abstract：:Vitamin K-antagonists and heparin belong to the established indirect acting anticoagulants. For many years these drugs were the only possibility for prophylaxis and treatment of venous and arterial thrombosis. The challenges for the routine laboratory related to the treatment with vitamin K-antagonists and heparin can...

journal_title：Hamostaseologie

authors： Schuster B

更新日期：2009-08-01 00:00:00

abstract：:The translation of fundamental science-based constructs to the preemptive identification and optimal management of individuals with or those at risk for thrombotic disorders of the cardiovascular system has taken a step closer to being realized with the development of molecular technologies that include nucleic acid a...

journal_title：Hamostaseologie

authors： Becker RC,Oney S,Becker KC,Rusconi CP,Sullenger B

更新日期：2007-12-01 00:00:00

abstract：:Vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) is an enzyme essential for the vitamin K cycle. VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. The generated vitamin K hydroquinone serves as substrate for the enzyme γ-glutamyl-...

journal_title：Hamostaseologie

authors： Czogalla KJ,Watzka M,Oldenburg J

更新日期：2016-11-08 00:00:00

abstract：:This case report concerns a pregnant multipara (age: 27 years) in the 16th gestational week. She developed a sudden onset of paraesthesia in her left lower arm although injecting dalteparin 5000 IU once daily subcutaneously (s. c.) due to a heterozygous factor V Leiden mutation and a prior miscarriage in the first pre...

journal_title：Hamostaseologie

authors： Hecking C,Hendelmeier M,von Bardeleben R,Gröschel K,Schinzel H

更新日期：2014-01-01 00:00:00

abstract：UNLABELLED:Clinical expression of inadequately treated haemophilia is dominated by orthopedic complications, requiring invasive or non-invasive interventions. OBJECTIVE:In Romania, with under dosed and late introduced "on demand" substitution, we aimed at highlighting the experience of orthopedic treatment and its out...

journal_title：Hamostaseologie

authors： Serban M,Mihailov MD,Poenaru D,Pop L,Branea I,Bataneant M,Lăcătuşu A,Barna L,Tepeneu N,Schramm W

更新日期：2008-10-01 00:00:00

abstract：:Replacement therapy of coagulation factor preparations (AT, FFP, PPSB, FXIII, rFVIIa) are frequently used on the Intensive Care Units. Indications, dosage, specific effects and side effects have to be considered. ...

journal_title：Hamostaseologie

authors： Scharrer I

更新日期：2005-05-01 00:00:00

abstract：:Nearly every second patient, who needs an oral anticoagulation with vitamin K antagonists, is feasible to perform INR-self-management after participation in a structured teaching program. Patient self-testing or measuring the INR value by relatives or nurses would increase this method of control by the aid of telemedi...

journal_title：Hamostaseologie

authors： Völler H,Braun S

更新日期：2008-10-01 00:00:00

abstract：:Von Willebrand disease (VWD) is known for its marked heterogeneity which was already recognized by von Willebrand in 1926. The basis of phenotypic differentiation are quantitative and qualitative or functional differences between the different types and subtypes of VWD. One of the most important tools in the classific...

journal_title：Hamostaseologie

authors： Schneppenheim R,Budde U

更新日期：2004-02-01 00:00:00

abstract：:Clinically overt, preoperative, disseminated intravascular coagulation (DIC) is not common in patient with aortic aneurysm. However, cases with large and expanding aneurysm are especially prone for this coagulopathy. Contrary to the clinically overt form compensated DIC in patients with aortic aneurysm seems frequent ...

journal_title：Hamostaseologie

authors： Jeleńska MM

更新日期：2004-08-01 00:00:00

abstract：UNLABELLED:Molecular genetic testing for factor VIII (FVIII) mutations is indicated in haemophilia A since determination of FVIII activity cannot reliably identify female carriers. Given the large number of FVIII mutations the identification of novel mutations is not uncommon. Since amino acid polymorphisms of FVIII ar...

journal_title：Hamostaseologie

authors： Schneppenheim R,Schröder J,Obser T,Oyen F,Schneppenheim S,Oldenburg J

更新日期：2009-05-01 00:00:00

abstract：:Patients with diabetes are at increased risk of cardiovascular morbidity and mortality. While arteriosclerotic lesions have long been recognized as the underlying cause more recent studies suggest that alterations of the blood are also critically involved. Following plaque rupture, adherence of platelets is followed b...

journal_title：Hamostaseologie

authors： Hess K

更新日期：2015-01-01 00:00:00

abstract：:Recent advances in the diagnosis and the treatment of acute coronary syndromes (ACS) have led to a substantial reduction of major coronary events, to an improvement in patient outcome and the definition of new guidelines. Current strategies for the treatment of patients with non-ST-elevation ACS recommend a combined a...

journal_title：Hamostaseologie

authors： Hölschermann H

更新日期：2007-12-01 00:00:00

abstract：UNLABELLED:In recent years thrombophilia has gained much attention as a risk factor for pregnancy complications. Whereas there is an established correlation between antiphospholipid-antibodies and pregnancy loss, data for other risk factors of thrombosis are less well established. Data suggest associations with antithr...

journal_title：Hamostaseologie

authors： Pabinger I

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION: Regular visits at haemophilia treatment centres (HTCs) in rural regions are often dependent on the access to a private car due to lack of or limited availability of public means. Therefore, a mobile haemophilia outpatient care (MHOC) concept providing home visits to haemophilia patients has been developed...

journal_title：Hamostaseologie

authors： Eichler H,Schleicher C,Heine S,Graf N,von Mackensen S

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION: Platelet dysfunction is not uncommon in patients with end-stage renal disease (ESRD). Type of renal replacement therapy may have an effect on platelet functions, which has not been well investigated. We evaluated in vitro closure time (CT) differences between peritoneal dialysis (PD) and hemodialysis (HD)...

journal_title：Hamostaseologie

authors： Gokalp C,Karadag FK,Braunisch MC,Schmaderer C,Gunay E,Kiper HD,Tobu M,Ustün C,Demirci MS,Ozkahya M

更新日期：2020-12-01 00:00:00

abstract：:The DHR (Deutsches Hämophilieregister, German Haemophilia Register) records patient data on haemophilia A, haemophilia B, von Willebrand disease, and other coagulation factor deficiency disorders. The DHR has been online since 2009. The participation in the DHR leads to additional administrative workload for the hospi...

journal_title：Hamostaseologie

authors： Haschberger B,Hesse J,Heiden M,Seitz R,Schramm W

更新日期：2010-11-01 00:00:00

abstract：:Epidemiological studies revealed that most antineoplastic agents and regimes enhance the risk of venous and arterial thromboembolic events in cancer patients. The purpose of this article is to review clinical and pathophysiological data related to chemotherapy-associated thromboembolism under special consideration of ...

journal_title：Hamostaseologie

authors： Lechner D,Weltermann A

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:Clot waveform analysis extends the interpretation of aPTT measurement curves. The curve is mathematically processed to obtain information about fibrin formation kinetics including semiquantitative determination of thrombin, prothrombinase and tenase activity. PATIENTS, METHOD:In this study the feasibility o...

journal_title：Hamostaseologie

authors： Siegemund T,Scholz U,Schobess R,Siegemund A

更新日期：2014-01-01 00:00:00

abstract：AIM:In children, screening for haemorrhagic disorders is further complicated by the fact that infants and young children with mild disease in many cases most likely will not have a significant history of easy bruising or bleeding making the efficacy of a questionnaire even more questionable. PATIENTS, METHODS:We compa...

journal_title：Hamostaseologie

authors： Music I,Novak M,Acham-Roschitz B,Muntean W

更新日期：2009-10-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is defined by the association of arterial and/or venous thrombosis and/or pregnancy complications with the presence of at least one among the main antiphospholipid antibodies (aPL) (i. e., Lupus anticoagulants, LA, IgG and/or IgM anticardiolipin antibodies, aCL, IgG and/or IgM antiβ...

journal_title：Hamostaseologie

authors： Galli M

更新日期：2011-11-01 00:00:00

abstract：:Atherosclerosis and its major complications - myocardial infarction and stroke - remain major causes of death and disability in the United States and world-wide. Indeed, with dramatic increases in obesity and diabetes mellitus, the prevalence and public health impact of cardiovascular diseases (CVD) will likely remain...

journal_title：Hamostaseologie

authors： Sun QA,Runge MS,Madamanchi NR

更新日期：2016-05-10 00:00:00

abstract：UNLABELLED:The retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. RESULTS:During the ob...

journal_title：Hamostaseologie

authors： Kocher S,Asmelash G,Makki V,Müller S,Krekeler S,Alesci S,Miesbach W

更新日期：2012-01-01 00:00:00

abstract：:Thrombocytosis (defined as platelets >450 x 109/l) has several aetiologies. After having excluded spurious thrombocytosis (e. g., due to microspherocytes, schistocytes, cryoglobulins, or bacteria), the differential diagnosis of true thrombocytosis encompasses secondary causes (as diverse as inflammation, infection, ma...

journal_title：Hamostaseologie

authors： Alberio L

更新日期：2016-11-07 00:00:00