Dopamine profoundly suppresses excitatory transmission in neonatal rat hippocampus via phosphatidylinositol-linked D1-like receptor.

abstract：:In several tauopathies such as Alzheimer's disease (AD), an increased incidence of seizures is observed. Tau, one of the major proteins implicated in AD pathology, is an important regulator of neural network excitability and might participate in the underlying epileptic cascade. However, the mechanisms underlying this...

journal_title：Neuroscience

authors： Van Erum J,Valkenburg F,Van Dam D,De Deyn PP

更新日期：2020-01-15 00:00:00

abstract：:In the hippocampus, chelatable zinc is accumulated in vesicles of glutamatergic presynaptic terminals, abounding specially in the mossy fibers, from where it is released with activity and can exert a powerful inhibitory action upon N-methyl-D-aspartate receptors. Zinc is therefore in a strategic situation to control o...

journal_title：Neuroscience

authors： Domínguez MI,Blasco-Ibáñez JM,Crespo C,Marqués-Marí AI,Martínez-Guijarro FJ

更新日期：2003-01-01 00:00:00

abstract：:Angiogenesis after intracerebral hemorrhage (ICH) injury can effectively alleviate brain damage and improve neurological function. Hypoxia-inducible factor 2α (HIF-2α) is an important angiogenic regulator and exhibits protective effects in several neurological diseases; however, its role in ICH has not yet been report...

journal_title：Neuroscience

authors： Chen H,Xiao H,Gan H,Zhang L,Wang L,Li S,Wang D,Li T,Zhai X,Zhao J

更新日期：2020-11-10 00:00:00

abstract：:The effects of intense noise exposure on the classical auditory pathway have been extensively investigated; however, little is known about the effects of noise-induced hearing loss on non-classical auditory areas in the brain such as the lateral amygdala (LA) and striatum (Str). To address this issue, we compared the ...

journal_title：Neuroscience

authors： Chen GD,Sheppard A,Salvi R

更新日期：2016-02-19 00:00:00

abstract：:It has previously been demonstrated, in dual probe microdialysis studies, that stimulation of the neostriatum with kainic acid causes the release of GABA both locally within the neostriatum and distally in the substantia nigra, observations that are consistent with the known anatomy of the basal ganglia. The object of...

journal_title：Neuroscience

authors： Bianchi L,Colivicchi MA,Bolam JP,Della Corte L

更新日期：1998-11-01 00:00:00

abstract：:GABAergic neurons are coextensive with cholinergic neurons in the medial septum-diagonal band complex. Serial sectioning, sequential staining and double immunofluorescence techniques employing antibodies to glutamate decarboxylase and choline acetyltransferase revealed the distribution of these transmitter-specific ne...

journal_title：Neuroscience

authors： Brashear HR,Zaborszky L,Heimer L

更新日期：1986-02-01 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of ho...

journal_title：Neuroscience

authors： Song C,Merali Z,Anisman H

更新日期：1999-01-01 00:00:00

abstract：:Activation of poly (ADP-ribose) polymerases (PARP) contributes to ischemic damage by causing neuronal nicotinamide adenine dinucleotide (NAD(+)) depletion, release of apoptosis-inducing factor and consequent caspase-independent cell death. PARP-mediated cell death is sexually dimorphic, participating in ischemic damag...

journal_title：Neuroscience

authors： Vagnerova K,Liu K,Ardeshiri A,Cheng J,Murphy SJ,Hurn PD,Herson PS

更新日期：2010-03-17 00:00:00

abstract：:To evaluate the reversibility of neural function in the brainstem following ischemia, we investigated the effect of transient brainstem ischemia on the brainstem auditory evoked potential in gerbils. Brainstem ischemia was produced by bilateral extracranial occlusion of vertebral arteries. Local cerebral blood flow wa...

journal_title：Neuroscience

authors： Hata R,Matsumoto M,Matsuyama T,Yamamoto K,Hatakeyama T,Kubo T,Mikoshiba K,Sakaki S,Sugita M,Yanagihara T

更新日期：1998-03-01 00:00:00

abstract：:How does our mind produce physical, goal-directed action of our body? For about 200years, philosophers and psychologists hypothesized the transformation from mind to body to rely on the anticipation of an action's sensory consequences. Whereas this hypothesis received tremendous support from behavioral experiments, th...

journal_title：Neuroscience

authors： Pfister R,Melcher T,Kiesel A,Dechent P,Gruber O

更新日期：2014-02-14 00:00:00

abstract：:Fetal alcohol spectrum disorder is associated with defects in neuronal generation, migration, and differentiation. The present study tested the hypothesis that ethanol exposure during the period of naturally occurring neuronal death causes a time- and Bax-dependent neuronal loss. Wild-type and Bax knockout mice were g...

journal_title：Neuroscience

authors： Britton SM,Miller MW

更新日期：2018-01-15 00:00:00

abstract：:The effect of exogenously applied cholinergic agents upon mitral-granule cell complex activity of the olfactory bulb was studied in anesthetized rats. Output neurons were activated by electrical paired-pulse stimulation (40-80 ms time interval) applied either to the olfactory nerve (orthodromic stimulation) or to the ...

journal_title：Neuroscience

authors： Elaagouby A,Ravel N,Gervais R

更新日期：1991-01-01 00:00:00

abstract：:Central neuropathic pain (CNP) in the spinal cord, such as chronic pain after spinal cord injury (SCI), is an incurable ailment. However, little is known about the spinal cord mechanisms underlying CNP. Recently, reactive oxygen species (ROS) have been recognized to play an important role in CNP of the spinal cord. Ho...

journal_title：Neuroscience

authors： Nishio N,Taniguchi W,Sugimura YK,Takiguchi N,Yamanaka M,Kiyoyuki Y,Yamada H,Miyazaki N,Yoshida M,Nakatsuka T

更新日期：2013-09-05 00:00:00

abstract：:We previously showed that magnesium sulfate (MS) has systemic antinociceptive and local peripheral pronociceptive effects. The role of transient receptor potential (TRP) channels and acid-sensing ion channels (ASICs) in the mechanism of action of MS has not been investigated in detail. The aim of this study was to exp...

journal_title：Neuroscience

authors： Srebro D,Vučković S,Prostran M

更新日期：2016-12-17 00:00:00

abstract：:The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The metabotropic glutamate receptors first d...

journal_title：Neuroscience

authors： Birse EF,Eaton SA,Jane DE,Jones PL,Porter RH,Pook PC,Sunter DC,Udvarhelyi PM,Wharton B,Roberts PJ

更新日期：1993-02-01 00:00:00

abstract：:The present study utilized an in vitro preparation of the rabbit carotid body, with tissue catecholamine stores labeled by incubation with 3H-tyrosine. The goal was to characterize pharmacologically the voltage-dependent Ca2+ channels present in the type I (glomus) cells of this arterial chemoreceptor organ, and to el...

journal_title：Neuroscience

authors： Obeso A,Rocher A,Fidone S,Gonzalez C

更新日期：1992-01-01 00:00:00

abstract：:We have studied the roles of nicotinic and muscarinic receptors in the acetylcholine-evoked secretion of catecholamine from guinea-pig chromaffin cells. Isolated guinea-pig chromaffin cells secrete catecholamine in response to acetylcholine, nicotine, and a variety of muscarinic agonists. Optimal concentrations of ace...

journal_title：Neuroscience

authors： Role LW,Perlman RL

更新日期：1983-11-01 00:00:00

abstract：:In order to study structural alterations which occur after a defined unilateral cortical infarct, the hindlimb region of the rat cortex was photochemically lesioned. The infarcts caused edema restricted to the perilesional cortex which affected allocortical and isocortical areas differently. Postlesional changes in cy...

journal_title：Neuroscience

authors： Bidmon HJ,Jancsik V,Schleicher A,Hagemann G,Witte OW,Woodhams P,Zilles K

更新日期：1998-01-01 00:00:00

abstract：:Intracellular and whole-cell patch-clamp recordings were obtained from sympathetic preganglionic neurons in rat spinal cord slices. Perfusion of selective ionotropic and metabotropic excitatory amino acid agonists induced depolarizing responses in all neurons. In approximately 20% of neurons the application of these a...

journal_title：Neuroscience

authors： Spanswick D,Pickering AE,Gibson IC,Logan SD

更新日期：1994-09-01 00:00:00

abstract：:We have used the evoked expression of the immediate early gene-encoded proteins (c-Fos, Fos B, Jun B, Jun D, c-Jun and Krox-24) to monitor sensory processing in the hindbrain structures of rats undergoing somatic inflammation. Experiments were performed on freely moving animals that did not experience constraints othe...

journal_title：Neuroscience

authors： Lantéri-Minet M,Weil-Fugazza J,de Pommery J,Menétrey D

更新日期：1994-01-01 00:00:00

abstract：:Perinatal asphyxia and hypoxia are common causes of morbidity in neonates. Prenatal birth associated with hypoxemia often results in several disorders because of the lack of oxygen in the brain. Survival rates from perinatal hypoxia have improved, but appropriate treatments for recovery are still limited, with great i...

journal_title：Neuroscience

authors： Coveñas R,González-Fuentes J,Rivas-Infante E,Lagartos-Donate MJ,Cebada-Sánchez S,Arroyo-Jiménez MM,Insausti R,Marcos P

更新日期：2014-06-20 00:00:00

abstract：:The after-effects of locomotor stimulation are a transient facilitation of locomotor initiation (the priming effect), and a transient increase in hippocampal rhythmic slow activity in the 3-6 Hz band of the theta range. The similar time course of the two effects suggests that hippocampal 3-6 Hz activity may be linked ...

journal_title：Neuroscience

authors： Sinnamon HM

更新日期：2000-01-01 00:00:00

abstract：:Physiological evidence has indicated that serotonin (5-hydroxytryptamine) could be a regulator of cerebral blood flow in various regions of the brain. In the present study, tryptophan hydroxylase immunocytochemistry was used to characterize, both at the light and electron microscopic levels, serotonergic nerve termina...

journal_title：Neuroscience

authors： Cohen Z,Ehret M,Maitre M,Hamel E

更新日期：1995-06-01 00:00:00

abstract：:Substance P is known to elicit diverse actions via activating multiple subtypes of tachykinin receptors, and these actions appear to be involved not only in synaptic transmission but also in synaptic plasticity during development of the mammalian central nervous system. The availability of sensitive quantitation of in...

journal_title：Neuroscience

authors： Taoka M,Song SY,Kubota M,Minegishi A,Yamakuni T,Konishi S

更新日期：1996-10-01 00:00:00

abstract：:An increased frequency of apolipoprotein E E4 allele has been reported in patients with late onset Alzheimer's disease. Apolipoprotein E participates in the transport of cholesterol and other lipids and interferes with the growth and regeneration of both peripheral and central nervous system tissues during development...

journal_title：Neuroscience

authors： Lehtovirta M,Laakso MP,Soininen H,Helisalmi S,Mannermaa A,Helkala EL,Partanen K,Ryynänen M,Vainio P,Hartikainen P

更新日期：1995-07-01 00:00:00

abstract：:A systematic line-sampling method is described for counting and mapping myelinated axons in transverse sections of the spinal cord. Its advantages over random sampling of small areas are considered. The technique was applied to quantifying experimental weight-drop contusion injuries of cat spinal cord, from several mo...

journal_title：Neuroscience

authors： Blight AR

更新日期：1983-10-01 00:00:00

abstract：:Synaptic plasticity involves remodeling of extracellular matrix. This is mediated, in part, by enzymes of the matrix metalloproteinase (MMP) family, in particular by gelatinase MMP-9. Accordingly, there is a need of developing methods to visualize gelatinolytic activity at the level of individual synapses, especially ...

journal_title：Neuroscience

authors： Gawlak M,Górkiewicz T,Gorlewicz A,Konopacki FA,Kaczmarek L,Wilczynski GM

更新日期：2009-01-12 00:00:00

abstract：:Gonadal hormones are known to influence the regulation of emotional responses and affective states. Whereas fluctuations in progesterone and estradiol are associated with increased vulnerability for mood disorders, testosterone is mainly associated with social dominance, aggressive, and antisocial behavior. Here, we r...

journal_title：Neuroscience

authors： van Wingen GA,Ossewaarde L,Bäckström T,Hermans EJ,Fernández G

更新日期：2011-09-15 00:00:00

abstract：:In vivo voltammetry was used to study the effects of basolateral amygdala dopamine depletion on stress-induced dopamine release in the nucleus accumbens and medial prefrontal cortex. Male Long-Evans rats received bilateral microinjections of 6-hydroxydopamine or vehicle into the basolateral amygdala. Changes in dopami...

journal_title：Neuroscience

authors： Stevenson CW,Sullivan RM,Gratton A

更新日期：2003-01-01 00:00:00

abstract：:The granular layer of the cerebellar cortex consists of densely packed neuronal cells, classified into granule cells and large interneurons. In this study, we provide a comparative survey of large granular layer interneurons in the adult rat cerebellum based on both morphological and neurochemical criteria. To this en...

journal_title：Neuroscience

authors： Geurts FJ,Timmermans J,Shigemoto R,De Schutter E

更新日期：2001-01-01 00:00:00