Repair of mandible defect with tissue engineering bone in rabbits.


BACKGROUND:The aim of the present study was to investigate the effect of tissue engineering bone composed of bone marrow-derived osteoblasts and demineralized bone in repairing mandible defect. METHODS:Bone marrow-derived osteoblasts of 20 rabbits were cultured and seeded into scaffold of allogeneic demineralized bone to construct tissue engineering bone graft in vitro, which was used to repair the 10 x 5-mm bone defect made in the same rabbit mandible edge. Implant of demineralized bone alone was as the control. Rabbits were killed according to the schedule: five after 2 weeks, five after 4 weeks, five after 8 weeks, five after 12 weeks, and the implants were harvested for gross, radiographic, and histological observation. RESULTS:New bone formation at the margin region of defect and osteogenesis at the centre were observed in the implant of tissue engineering bone, and the bone formation pattern included osteogenesis, osteoconduction, and osteoinduction. In the implant of demineralized bone alone, the major bone formation pattern was 'creeping substitute'. CONCLUSIONS:The tissue engineering bone graft constructed by autogenous bone marrow-derived osteoblasts and allogeneic demineralized bone was better than demineralized bone alone in bone formation capability, which might be an ideal graft for bone defect repair.


ANZ J Surg


ANZ journal of surgery


Li Z,Li ZB





Has Abstract


2005-11-01 00:00:00














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    abstract:BACKGROUND:The aim of this study was to review the discrepancies in Gleason scores (GS) of prostate biopsies and radical prostatectomy specimens and the effects of multiple-needle biopsies on scoring accuracy. METHODS:One hundred patients who had undergone consecutive radical prostatectomies (RP) between January 2004 ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章


    authors: Ooi K,Samali R

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Motson RW,Kelly MD

    更新日期:2002-04-01 00:00:00

  • Audit of the Douglas Hocking Research Institute bone bank: ten years of non-irradiated bone graft.

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    authors: Kaman L,Behera A,Singh R,Katariya RN

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  • Factors influencing donor and recipient decision making in adult-to-adult living donor liver transplantation: a survey of a non-transplant population.

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    pub_type: 杂志文章


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    更新日期:2008-06-01 00:00:00

  • Reduction in hospital admissions with an early computed tomography scan: results of an outpatient management protocol for uncomplicated acute diverticulitis.

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  • Orbital exenterations: an 18-year experience from a single head and neck unit.

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    pub_type: 杂志文章,随机对照试验


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  • Regional nodal metastasis and 5-year survival in patients with thin melanoma in Queensland: a population-based study.

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  • Preoperative anaemia and thrombocytopenia are associated with venous thromboembolism complications after colorectal resection.

    abstract:BACKGROUND:Earlier studies have shown that abnormal levels of haemoglobin and platelets may be associated with worse post-operative outcomes. We aim to compare the rates of venous thromboembolism (VTE), anastomotic leak and other complications in patients post-colorectal resection with normal and abnormal levels of hae...

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  • Sustaining the surgical educator workforce in Australia and New Zealand.

    abstract:BACKGROUND:The education and training of tomorrow’s surgeons are predicated upon the involvement of a broad spectrum of surgical educators. Identification of the factors that influence their ongoing participation is crucial for its continuity. METHODS:A study was performed on 695 surgeons identified as having major in...

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