Nanoscale polymer carriers to deliver chemotherapeutic agents to tumours.

abstract：IMPORTANCE OF THE FIELD:The therapeutic use of platelet-rich plasma (PRP) is an autologous biotechnology that relies on the local delivery of a wide range of growth factors and cytokines with the aim of enhancing tissue healing. Understanding both tendon healing and PRP therapies is an area of research that is critical...

journal_title：Expert opinion on biological therapy

authors： Andia I,Sanchez M,Maffulli N

更新日期：2010-10-01 00:00:00

abstract：:This review discusses the present outlook for new thrombocytopenia therapies that induce haematopoietic stem and progenitor cells to proliferate, differentiate and produce functional platelets. A brief overview of megakaryopoiesis and its regulation by thrombopoietin (TPO) is followed by a discussion of how early expe...

journal_title：Expert opinion on biological therapy

authors： Szilvassy SJ

更新日期：2006-10-01 00:00:00

abstract：:Defibrotide is a polydisperse oligonucleotide with antiatherosclerotic, anti-inflammatory, anti-ischaemic, pro-fibrinolytic and antithrombotic actions without significant systemic anticoagulant effects. It has been used in the treatment of various cardiovascular disorders, and especially in endothelial complications o...

journal_title：Expert opinion on biological therapy

authors： Morabito F,Gentile M,Gay F,Bringhen S,Mazzone C,Vigna E,Musto P,Di Raimondo F,Palumbo A

更新日期：2009-06-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a congenital immune deficiency that is a promising therapeutic target for gene replacement into haematopoietic stem cells (HSCs). CGD results from mutations in any one of four genes encoding subunits of the superoxide-generating NADPH oxidase of phagocytes. Life-threatening, recu...

journal_title：Expert opinion on biological therapy

authors： Barese CN,Goebel WS,Dinauer MC

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:IL-21, a recently described common gamma-chain cytokine, can induce the maturation and enhanced cytotoxicity of natural killer (NK) and CD8(+) T cells and proliferation of CD40-stimulated B cells. Exogenous IL-21 has antitumor effects in murine models via immunological mechanisms. In addition, IL-21 can also...

journal_title：Expert opinion on biological therapy

authors： Andorsky DJ,Timmerman JM

更新日期：2008-09-01 00:00:00

abstract：:Complete resection is mandatory in order to achieve a cure in patients with early-stage non-small cell lung cancer (NSCLC). However, despite complete resection, a substantial proportion of patients have disease recurrence, with distant metastases being the primary sites of failure. Recent trials have conclusively demo...

journal_title：Expert opinion on biological therapy

authors： Potti A,Ganti AK

更新日期：2006-07-01 00:00:00

abstract：:B cell targeted therapy using rituximab, a genetically engineered chimeric mouse/human monoclonal antibody, is recommended for patients with active rheumatoid arthritis who have failed to respond to both conventional disease-modifying drugs and TNF inhibitors. The value of ritixumab in patients with earlier disease, w...

journal_title：Expert opinion on biological therapy

authors： Khan A,Scott D

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Although catalytic RNA enzymes (CRzs) are naturally occurring in many organisms, their DNA counterparts (CDzs) were developed by in vitro selection/evolution from random sequence libraries. OBJECTIVE:To provide a brief overview of how CDzs have been selected in vitro, and of their properties and functions, ...

journal_title：Expert opinion on biological therapy

authors： Pan W,Clawson GA

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:Oral health is affected by its resident microorganisms. Three prominent oral disorders are dental caries, gingivitis and periodontitis, with the oral microbiota playing a key role in the initiation/progression of all three. Understanding the microbiota and the diseases they may cause is critical to the dev...

journal_title：Expert opinion on biological therapy

authors： Saha S,Tomaro-Duchesneau C,Tabrizian M,Prakash S

更新日期：2012-09-01 00:00:00

abstract：:Malaria remains an important public health problem throughout the tropical world causing immense human suffering and impeding economic development. Despite extensive research for > 100 years, options for preventing malaria remain limited to vector control and chemoprophylaxis. The complexity of the organism and its li...

journal_title：Expert opinion on biological therapy

authors： Wipasa J,Riley EM

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Coronary artery disease commonly leads to myocardial ischaemia and hibernation. Relevant preclinical models of these conditions are essential to evaluate new therapeutic options such as cell-based vasculogenic therapies. AREAS COVERED:In this article, the authors first review basic concepts of myocardial ...

journal_title：Expert opinion on biological therapy

authors： Giordano C,Kuraitis D,Beanlands RS,Suuronen EJ,Ruel M

更新日期：2013-03-01 00:00:00

abstract：:Daclizumab is a humanized monoclonal antibody which binds to the IL-2 receptor on activated lymphocytes and blocks the production of IL-2. Its use is well established in solid organ transplantation as induction therapy, especially in high-risk patients where reduction or delayed dose of standard immunosuppression woul...

journal_title：Expert opinion on biological therapy

authors： Mottershead M,Neuberger J

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:Gastrointestinal cancers contribute to a significant number of cancer- associated mortality. The gastrointestinal tract harbors a multitude of microorganisms, known as the microbiota. Recently, the microbiota is considered to be an accessory organ resulting in several health benefits. The microbiota is inv...

journal_title：Expert opinion on biological therapy

authors： Khan AA,Nema V,Khan Z

更新日期：2020-10-09 00:00:00

abstract：INTRODUCTION:Statins are currently the most commonly used agents for treatment of hypercholesterolemia in patients with atherosclerotic cardiovascular disease. However, some patients on statins do not achieve their treatment goals or are intolerant to statins. Therefore, new therapies for treatment of hypercholesterole...

journal_title：Expert opinion on biological therapy

authors： Valerio MG,Velayati A,Jain D,Aronow WS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Current gene-based strategies for treatment of erectile dysfunction (ED) are based on the nitric oxide (NO)/cGMP system; although growth factors, calcium sensitization, and potassium channel expression have been studied. Initial investigations of stem-cell-based therapy have attracted attention. Results of t...

journal_title：Expert opinion on biological therapy

authors： Gur S,Kadowitz PJ,Hellstrom WJ

更新日期：2008-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Muscle-directed gene therapy for genetic muscle diseases can be performed by the recombinant adeno-associated viral (rAAV) vector delivery system to achieve long-term therapeutic gene transfer in all affected muscles. AREAS COVERED IN THIS REVIEW:Recent progress in rAAV-vector-mediated muscle-d...

journal_title：Expert opinion on biological therapy

authors： Tang Y,Cummins J,Huard J,Wang B

更新日期：2010-03-01 00:00:00

abstract：:Soft tissue sarcomas are a challenge for medical oncology and gene therapy. Protective and sensitising approaches that target normal and malignant tissue, respectively, both have their role for opening the therapeutic window. Recent data show that an intensive maintenance chemotherapy significantly reduces metastatic ...

journal_title：Expert opinion on biological therapy

authors： Fruehauf S,Veldwijk MR,Zeller WJ,Laufs S

更新日期：2003-12-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs), and are capable of stimulating naive T cells and driving primary immune responses. Due to this unique property, DCs represent both vectors and targets for immunological intervention in numerous diseases and are optimal candidates f...

journal_title：Expert opinion on biological therapy

authors： Tatsumi T,Storkus WJ

更新日期：2002-12-01 00:00:00

abstract：INTRODUCTION:Multiple sclerosis (MS) is a chronic and progressive inflammatory demyelinating disease of the human central nervous system (CNS) and is the most common disabling neurological condition in young adults, resulting in severe neurological defects. No curative or long-term progression-inhibiting therapy has ye...

journal_title：Expert opinion on biological therapy

authors： Perwein MK,Smestad JA,Warrington AE,Heider RM,Kaczor MW,Maher LJ 3rd,Wootla B,Kunbaz A,Rodriguez M

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:The treatment of patients with type 2 diabetes mellitus remains challenging, as it goes beyond adequate glycemic control, in particular addressing weight, blood pressure and other contributors to cardiovascular disease. In addition, the progressive nature of type 2 diabetes mellitus demands the intensifica...

journal_title：Expert opinion on biological therapy

authors： Stinkens K,Peene B,Mathieu C

更新日期：2016-09-01 00:00:00

abstract：:Dendritic cells (DCs) and natural killer (NK) cells play a critical role in early defences against cancer and infections. They specialise in complementary functions, including IL-12 or IFN-alpha/beta secretion and antigen presentation for the former, and IFN-gamma secretion and killing of infected or tumour cells for ...

journal_title：Expert opinion on biological therapy

authors： Walzer T,Dalod M,Vivier E,Zitvogel L

更新日期：2005-09-01 00:00:00

abstract：INTRODUCTION:The efficacy of anti-TNFα agents has been recently evaluated in many studies in Behçet's disease (BD), particularly in ocular and life-threatening manifestations such as neurological and vascular disease. Areas covered: The following article aims to summarize the currently available efficacy and safety dat...

journal_title：Expert opinion on biological therapy

authors： Desbois AC,Vallet H,Domont F,Comarmond C,Cacoub P,Saadoun D

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:In the last two decades, with the development of biological (anti-TNFα) therapy, the treatment paradigms for Crohn's disease and ulcerative colitis have evolved, with a continuously increasing role of biologicals. Some patients, however, experience lack- or loss of response (LOR) to treatment, and manageme...

journal_title：Expert opinion on biological therapy

authors： Miheller P,Kiss LS,Lorinczy K,Lakatos PL

更新日期：2012-02-01 00:00:00

abstract：:CD8+ T cells are pivotal in controlling viral replication in HIV-1-infected subjects. However, in chronic infection, HIV-1-specific CD8+ T cells fail to adequately control infection, presenting incomplete maturation and more severe functional impairment with advanced disease. Accumulating evidence has shown that CD8+ ...

journal_title：Expert opinion on biological therapy

authors： Meireles-de-Souza LR,Shattock RJ

更新日期：2005-03-01 00:00:00

abstract：INTRODUCTION:About 99% of all autologous transplants are now performed with blood stem cells. G-CSF alone or combined with chemotherapy have been used to mobilize CD34(+) cells. Plerixafor is a novel drug used for mobilization purposes. AREAS COVERED:We have evaluated recent data in regard to plerixafor use in predict...

journal_title：Expert opinion on biological therapy

authors： Jantunen E,Varmavuo V

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The marrow microenvironment is composed of a complex network of cells and extra cellular matrix that cooperate to regulate normal hematopoiesis. There is growing evidence that microenvironmental defects can contribute to the pathogenesis of hematological malignancies. OBJECTIVE/METHODS:We review the role of...

journal_title：Expert opinion on biological therapy

authors： Ramakrishnan A,Deeg HJ

更新日期：2009-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-A is a major regulator of angiogenesis and vascular permeability implicated in the development of diseases involving pathological angiogenesis and increased vascular permeability, such as neovascular age-related macular degeneration (AMD). LUCENTIS (ranibizumab), a humanized a...

journal_title：Expert opinion on biological therapy

authors： Pieramici DJ,Avery RL

更新日期：2006-11-01 00:00:00

abstract：INTRODUCTION:In hemophilia, advanced therapies are warranted from a conceptual and methodological standpoint. Current advanced therapy strategies are centered on the use of adeno-associated viral vectors, although problems related to immunogenicity and hepatotoxicity still remain. AREAS COVERED:Future clinical trials ...

journal_title：Expert opinion on biological therapy

authors： Liras A

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:We performed a systematic meta-analysis to assess the therapeutic effects of progenitor cell therapy after myocardial infarction (MI). RESEARCH DESIGN/METHODS:Randomized controlled trials of progenitor cell therapy for MI were extracted from MEDLINE. We performed a prospective comparison of progenitor cell t...

journal_title：Expert opinion on biological therapy

authors： Jiang M,He B,Zhang Q,Ge H,Zang MH,Han ZH,Liu JP,Li JH,Zhang Q,Li HB,Jin Y,He Q,Gong XR,Yin XY

更新日期：2010-05-01 00:00:00

abstract：:At present, the improvement of hygienic life standards is considered as an environmental condition, increasing the prevalence of allergic diseases, as early contact with some pathogens is, according to the hygiene hypothesis, required for maturation of the immune system. The recognition of microbial components involve...

journal_title：Expert opinion on biological therapy

authors： Lazarczyk M,Grzela K,Grzela T

更新日期：2005-04-01 00:00:00