Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant.

Abstract:

:Recently we identified a bacterial factor (BimA) required for actin-based motility of Burkholderia pseudomallei. Here we report that Burkholderia mallei and Burkholderia thailandensis are capable of actin-based motility in J774.2 cells and that BimA homologs of these bacteria can restore the actin-based motility defect of a B. pseudomallei bimA mutant. While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Stevens JM,Ulrich RL,Taylor LA,Wood MW,Deshazer D,Stevens MP,Galyov EE

doi

10.1128/JB.187.22.7857-7862.2005

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

7857-62

issue

22

eissn

0021-9193

issn

1098-5530

pii

187/22/7857

journal_volume

187

pub_type

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