The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G.

abstract：:Grasslands cover more than 20% of the Earth's terrestrial surface, and their rise to dominance is one of the most dramatic events of biome evolution in Earth history. Grasses possess two main photosynthetic pathways: the C(3) pathway that is typical of most plants and a specialized C(4) pathway that minimizes photores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards EJ,Smith SA

更新日期：2010-02-09 00:00:00

abstract：:Interleukin 3 (IL-3) stimulates the proliferation and differentiation of various haematopoietic progenitor cells. Recently, IL-3 and other cytokines were reported to exert a neurotrophic activity and to be associated with neurological disorders, suggesting their complex role in the central nervous system. We now show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chavany C,Vicario-Abejón C,Miller G,Jendoubi M

更新日期：1998-09-15 00:00:00

abstract：:The substrate specificity of thermophilic xylose isomerase from Clostridium thermosulfurogenes was examined by using predictions from the known crystal structure of the Arthrobacter enzyme and site-directed mutagenesis of the thermophile xylA gene. The orientation of glucose as a substrate in the active site of the th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meng M,Lee C,Bagdasarian M,Zeikus JG

更新日期：1991-05-01 00:00:00

abstract：:Down syndrome (DS) caused by trisomy of chromosome 21 is the most common genetic cause of intellectual disability. Although the prenatal diagnosis of DS has become feasible, there are no therapies available for the rescue of DS-related neurocognitive impairment. A growth inducer newly identified in our screen of neura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakano-Kobayashi A,Awaya T,Kii I,Sumida Y,Okuno Y,Yoshida S,Sumida T,Inoue H,Hosoya T,Hagiwara M

更新日期：2017-09-19 00:00:00

abstract：:The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sonoda E,Takata M,Yamashita YM,Morrison C,Takeda S

更新日期：2001-07-17 00:00:00

abstract：:Methylation on lysine 9 of histone H3 (H3K9me) and DNA methylation play important roles in the transcriptional silencing of specific genes and repetitive elements. Both marks are detected on class I and II endogenous retroviruses (ERVs) in murine embryonic stem cells (mESCs). Recently, we reported that the H3K9-specif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung DC,Dong KB,Maksakova IA,Goyal P,Appanah R,Lee S,Tachibana M,Shinkai Y,Lehnertz B,Mager DL,Rossi F,Lorincz MC

更新日期：2011-04-05 00:00:00

abstract：:Two chlorophyll-protein complexes associated with photosystem II (PSII) of the cyanobacterium Anacystis nidulans R2 have been detected. The larger of the two complexes, CPVI-1, contained a 71-kDa and a 42-kDa protein. The 71-kDa protein was determined to be the anchor protein of the phycobilisomes (the light-harvestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pakrasi HB,Riethman HC,Sherman LA

更新日期：1985-10-01 00:00:00

abstract：:The U.S. case against Iran is based on Iran's deceptions regarding nuclear weapons development. This case is buttressed by assertions that a state so petroleum-rich cannot need nuclear power to preserve exports, as Iran claims. The U.S. infers, therefore, that Iran's entire nuclear technology program must pertain to w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern R

更新日期：2007-01-02 00:00:00

abstract：:Recent single-molecule experiments reveal that mechanical tension on DNA can control both the speed and direction of the DNA polymerase motor. We present a theoretical description of this tension-induced "tuning" and "switching." The internal conformational states of the enzyme motor are represented as nodes, and the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goel A,Astumian RD,Herschbach D

更新日期：2003-08-19 00:00:00

abstract：:Peroxisome proliferators (PP) induce a highly predictable pleiotropic response in rat and mouse liver that is characterized by hepatomegaly, increase in peroxisome number in hepatocytes, and induction of certain peroxisomal enzymes. The PP-binding protein (PPbP) was purified from rat liver cytosol by a two-step proced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalwani ND,Alvares K,Reddy MK,Reddy MN,Parikh I,Reddy JK

更新日期：1987-08-01 00:00:00

abstract：:Chromosomes condense during mitotic entry to facilitate their segregation. Condensation is typically assayed in fixed preparations, limiting analysis of contributing factors. Here, we describe a quantitative method to monitor condensation kinetics in living cells expressing GFP fused to a core histone. We demonstrate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maddox PS,Portier N,Desai A,Oegema K

更新日期：2006-10-10 00:00:00

abstract：:L-Asparaginase (EC 3.5.1.1) inhibited respiration in sensitive, but not resistant, lines of murine lymphoma 6C3HED. Glucose, in these tumor lines, was principally converted to lactate, and very little was oxidized in the citric acid cycle or hexose monophosphate shunt. The cells derived 70-80% of their respiratory CO(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavietes BB,Regan DH,Demopoulos HB

更新日期：1974-10-01 00:00:00

abstract：:We used digital fluorescence microscopy to make real-time observations of anaphase chromosome movement and changes in microtubule organization in spindles assembled in Xenopus egg extracts. Anaphase chromosome movement in these extracts resembled that seen in living vertebrate cells. During anaphase chromosomes moved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray AW,Desai AB,Salmon ED

更新日期：1996-10-29 00:00:00

abstract：:Central nervous system (CNS) trauma can result in tissue disruption, neuronal and axonal degeneration, and neurological dysfunction. The limited spontaneous CNS repair in adulthood and aging is often insufficient to overcome disability. Several investigations have demonstrated that targeting HDAC activity can protect ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rivieccio MA,Brochier C,Willis DE,Walker BA,D'Annibale MA,McLaughlin K,Siddiq A,Kozikowski AP,Jaffrey SR,Twiss JL,Ratan RR,Langley B

更新日期：2009-11-17 00:00:00

abstract：:The NMR structures of three single-amino acid variants of the C-terminal domain of the human prion protein, hPrP(121-230), are presented. In hPrP(M166V) and hPrP(R220K) the substitution is with the corresponding residue in murine PrP, and in hPrP(S170N) it is with the corresponding Syrian hamster residue. All three su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calzolai L,Lysek DA,Guntert P,von Schroetter C,Riek R,Zahn R,Wüthrich K

更新日期：2000-07-18 00:00:00

abstract：:Plastid development in seedlings of Arabidopsis thaliana is affected by the transfer of (1)O(2)-mediated retrograde signals from the plastid to the nucleus and changes in nuclear gene expression during late embryogenesis. The potential impact of these mechanisms on plastid differentiation is maintained throughout seed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim C,Lee KP,Baruah A,Nater M,Göbel C,Feussner I,Apel K

更新日期：2009-06-16 00:00:00

abstract：:It recently has been shown that epithelial Na(+) channels are controlled by a receptor for intracellular Na(+), a G protein (G(o)), and a ubiquitin-protein ligase (Nedd4). Furthermore, mutations in the epithelial Na(+) channel that underlie the autosomal dominant form of hypertension known as Liddle's syndrome inhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishibashi H,Dinudom A,Harvey KF,Kumar S,Young JA,Cook DI

更新日期：1999-08-17 00:00:00

abstract：:Metallophilicity is defined as the interaction among closed-shell metal centers, the origin of which remains controversial, particularly for the roles of spd orbital hybridization (mixing of the spd atomic orbitals of the metal atom in the molecular orbitals of metal complex) and the relativistic effect. Our studies r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wan Q,Yang J,To WP,Che CM

更新日期：2021-01-05 00:00:00

abstract：:The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we identified a clear correlatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venetz D,Hess C,Lin CW,Aebi M,Neri D

更新日期：2015-02-17 00:00:00

abstract：:CTCF sites are abundant in the genomes of diverse species but their function is enigmatic. We used chromosome conformation capture to determine long-range interactions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the beta-globin locus and flanking olfactory receptor genes. Although CTCF occup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou C,Dale R,Dean A

更新日期：2010-02-23 00:00:00

abstract：:RNA of a common strain of tobacco mosaic virus was sequentially reconstituted first with protein of the same strain and then with protein of a tomato strain. The reconstituted particles were treated with specific antibodies against the two strain particles and were examined electron microscopically to locate the regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Otsuki Y,Takebe I,Ohno T,Fukuda M,Okada Y

更新日期：1977-05-01 00:00:00

abstract：:Diphosphoinositol pentakisphosphate (PP-IP5) and bis(diphospho)inositol tetrakisphosphate (bis-PP-IP4) are recently identified inositol phosphates that possess pyrophosphate bonds. We have purified an inositol hexakisphosphate (IP6) kinase from rat brain supernatants. The pure protein, a monomer of 54 kDa, displays hi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voglmaier SM,Bembenek ME,Kaplin AI,Dormán G,Olszewski JD,Prestwich GD,Snyder SH

更新日期：1996-04-30 00:00:00

abstract：:Accurate real-time tracking of influenza outbreaks helps public health officials make timely and meaningful decisions that could save lives. We propose an influenza tracking model, ARGO (AutoRegression with GOogle search data), that uses publicly available online search data. In addition to having a rigorous statistic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang S,Santillana M,Kou SC

更新日期：2015-11-24 00:00:00

abstract：:Autonomously replicating sequence (ARS) elements of the fission yeast Schizosaccharomyces pombe contain multiple imperfect copies of the consensus sequence reported by Maundrell et al. [Maundrell K., Hutchison, A. & Shall, S. (1988) EMBO J. 7, 2203-2209]. When cell free extracts of S. pombe were incubated with a dimer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami Y,Huberman JA,Hurwitz J

更新日期：1996-01-09 00:00:00

abstract：:The binding of bovine TSH (thyroid stimulating hormone), LH (luteinizing hormone), and their subunits to the TSH receptor of beef thyroid membranes was compared to stimulation by these agents of adenylate cyclase [ATP pyrophosphate-lyase(cyelizing), EC 4.6.1.1] in the same membranes, glucose oxidation in dog thyroid s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff J,Winand RJ,Kohn LD

更新日期：1974-09-01 00:00:00

abstract：:Gene expression is controlled by sequence-specific transcription factors (TFs), which bind to regulatory sequences in DNA. TF binding occurs in nucleosome-depleted regions of DNA (NDRs), which generally encompass regions with lengths similar to those protected by nucleosomes. However, less is known about where within ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grossman SR,Engreitz J,Ray JP,Nguyen TH,Hacohen N,Lander ES

更新日期：2018-07-24 00:00:00

abstract：:Predominant usage of V beta 8.2 gene segments, encoding a T-cell receptor (TCR) beta chain variable region, has been reported for pathogenic Lewis rat T cells reactive to myelin basic protein (MBP). However, up to 75% of the alpha/beta T cells in a panel of MBP-specific T-cell lines did not display TCR V beta 8.2, V b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gold R,Giegerich G,Hartung HP,Toyka KV

更新日期：1995-06-20 00:00:00

abstract：:The size of an organism reflects its metabolic rate, growth rate, mortality, and other important characteristics; therefore, the distribution of body size is a major determinant of ecosystem structure and function. Body-size distributions often are multimodal, with several peaks of abundant sizes, and previous studies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampert A,Tlusty T

更新日期：2013-01-02 00:00:00

abstract：:Antibody raised against the purified human erythrocyte glucose transporter specifically precipitated four proteins from normal and Rous sarcoma virus-transformed chicken embryo cells: a major protein of Mr 41,000 and minor proteins of Mr 68,000, 73,000, and 82,000. The Mr 41,000 and 82,000 proteins were found only in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salter DW,Baldwin SA,Lienhard GE,Weber MJ

更新日期：1982-03-01 00:00:00

abstract：:The origin recognition complex (ORC) binds sites from which DNA replication is initiated. We address ORC binding selectivity in vivo by mapping ∼52,000 ORC2 binding sites throughout the human genome. The ORC binding profile is broader than those of sequence-specific transcription factors, suggesting that ORC is not bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miotto B,Ji Z,Struhl K

更新日期：2016-08-16 00:00:00