Abstract:
:The verprolin family of proteins, WIP, CR16 and WIRE/WICH, has emerged as critical regulators of cytoskeletal organisation in vertebrate cells. The founding father of the family, verprolin, was originally identified in budding yeast and later shown to be needed for actin polymerisation during polarised growth and during endocytosis. The vertebrate verprolins regulate actin dynamics either by binding directly to actin, by binding the WASP family of proteins or by binding to other actin regulating proteins. Interestingly, also the vertebrate verprolins have been implicated in endocytosis, demonstrating that most of the functional modules in this fascinating group of proteins have been conserved from yeast to man.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Aspenström Pdoi
10.1016/j.febslet.2005.08.053keywords:
subject
Has Abstractpub_date
2005-10-10 00:00:00pages
5253-9issue
24eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01064-1journal_volume
579pub_type
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