Abstract:
:Safe and effective treatment of major depression, one of the most common comorbid conditions in individuals infected with HIV, significantly lowers morbidity and mortality from HIV disease. However, optimal treatment of both conditions is complicated by interactions between the disease processes as well as the pharmacological agents used to treat them. In patients with HIV it may be difficult to distinguish major depression from other physiological and emotional states that present with similar symptoms. Accurate diagnosis of major depression is thus complex and essential to preventing inappropriate exposure of patients to potentially harmful psychotropic medications. This review outlines important initial steps in making this diagnosis. All patients with HIV should be screened for depression by their medical providers and referred to a psychiatrist for full evaluation when necessary. The mainstay of treatment for major depression in patients with HIV disease is pharmacotherapy. Depressed patients with HIV respond to the same wide variety of antidepressant-class medications as depressed patients without HIV, including tricyclic antidepressants, paroxetine, fluoxetine and trazodone. Notably, new studies have also shown that some psychiatric medications can inhibit HIV replication. No particular antidepressant medication is superior for the treatment of depressed HIV-infected patients; however, the most important component of treatment of major depression in HIV-disease is patient adherence, which is highly influenced by antidepressant adverse effects. This review outlines adverse effects of antidepressant-class medications that are of particular concern in HIV-infected patients and describes pharmacological strategies for overcoming these potential barriers to medication adherence. This review also describes situations in which some adverse effects of antidepressant-class medications may be safely exploited to benefit depressed patients with HIV disease. Potential interactions between antidepressant-class medications and HIV medications, as well as pharmacological treatment strategies for treating the psychiatric adverse effects of HIV medications, are also discussed.
journal_name
Drug Safjournal_title
Drug safetyauthors
Pieper AA,Treisman GJdoi
10.2165/00002018-200528090-00002keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
753-62issue
9eissn
0114-5916issn
1179-1942pii
2892journal_volume
28pub_type
杂志文章,评审相关文献
DRUG SAFETY文献大全abstract:INTRODUCTION:The use of mobile apps is increasing in medicine. In pharmacovigilance, mobile apps may help to increase adverse drug reaction reporting and improve the communication of safety issues. The Toulouse University Pharmacovigilance Center has developed VigiBIP®, a free smartphone app available on Android and Ap...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-017-0630-2
更新日期:2018-05-01 00:00:00
abstract::Gastroesophageal reflux is one of the most common reasons for referrals to paediatricians or paediatric gastroenterologists. Gastric acid-buffering agents, mucosal surface barriers and gastric anti-secretory agents are the main groups of medications currently used for treating gastroesophageal reflux disease (GERD) in...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-014-0154-y
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Medication-related adverse events (MRAEs) form a large proportion of all adverse events in hospitalized patients and are associated with considerable preventable harm. Detailed information on harm related to drugs administered during hospitalization is scarce. Knowledge of the nature and preventability of MR...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11536800-000000000-00000
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Fatal venous thromboembolism (VTE) is a rare complication of combined oral contraceptive (COC) treatment. This study aims to determine incidences of fatal VTE in relation to the type of COC and the percentage of cases reported to the Swedish Adverse Drug Reactions Advisory Committee (SADRAC). A further aim i...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200528100-00007
更新日期:2005-01-01 00:00:00
abstract::Pharmacotherapy in pregnant women is often necessary to treat chronic or relapsing depression or anxiety disorders. Studies that have evaluated the safety of selective serotonin reuptake inhibitors (SSRIs) in early pregnancy have not shown an enhanced risk of major congenital malformations and these results may have c...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200528070-00002
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Thorough QT studies are typically conducted for drugs with systemic bioavailability and include a positive control, typically moxifloxacin, with a well-described QTc effect. OBJECTIVE:This study tested two hypotheses: that (i) re-measuring the QT intervals based on electrocardiogram (ECG) pattern similarity...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-014-0142-2
更新日期:2014-03-01 00:00:00
abstract::The risks and adverse effects of the low dose, new generation progestogen combined oral contraceptives (COCs) are much lower than original studies involving pills containing 50 micrograms estrogen. The main effects are those on the cardiovascular system, lipid and glucose metabolism and cancer. Any effect of the COC o...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199512020-00002
更新日期:1995-02-01 00:00:00
abstract::The introduction of MedDRA, the Medical Dictionary for Regulatory Activities, as a standardised terminology may have a major impact on the performance of risk management. Thus, MedDRA is likely to have an important effect on the analysis of clinical trial safety data. Review of the most commonly used terms in clinical...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200427080-00010
更新日期:2004-01-01 00:00:00
abstract::Pharmacovigilance science has traditionally been a discipline focussed on the postmarketing or post-authorisation period, with due attention directed towards pre-clinical safety data, clinical trials and adverse events. As the biological sciences have evolved, pharmacovigilance has slowly shifted toward earlier, proac...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200629080-00003
更新日期:2006-01-01 00:00:00
abstract::Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be an adverse reaction induced by drug therapy. In addition, some drugs have the propensity to adversely affect haemodynamic mechanisms in patients with an al...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200629070-00003
更新日期:2006-01-01 00:00:00
abstract::The mitochondrial respiratory chain (MRC) and ATP synthase (complex V) play an essential role in cellular energy production by the process of oxidative phosphorylation. In addition to inborn errors of metabolism, as well as secondary causes from disease pathophysiology, an impairment of oxidative phosphorylation can r...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-016-0417-x
更新日期:2016-07-01 00:00:00
abstract::The increasing incidence of Crohn's disease has lead to speculation about changes in exposures to environmental or infectious agents. Considerable attention has focused on the role of measles infection and/or vaccination in the pathogenesis of Crohn's disease and ulcerative colitis. Current evidence regarding the asso...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200124130-00001
更新日期:2001-01-01 00:00:00
abstract::Osteoporosis is a major public health problem occurring primarily among the postmenopausal population. Osteoporosis is a preventable disease, but despite several advances in its prevention, treatment of the established disease to date remains a major challenge to be managed by primary care physicians. Stabilisation of...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199411030-00004
更新日期:1994-09-01 00:00:00
abstract::The electrocardiographic effects of ebastine and its active metabolite, carebastine, have been studied alone and in relevant drug-interaction studies in various patient populations. The overall cardiac tolerability of ebastine is excellent. In ebastine dose-ranging studies in adults and children, there were no meaning...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199921001-00009
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:New pharmacovigilance legislation was adopted in the EU in 2010 and became operational in July 2012. The legislation placed an obligation on all national competent authorities (NCAs) and marketing authorisation holders (MAHs) to record and report cases of suspected adverse drug reactions (ADRs) received fr...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-017-0534-1
更新日期:2017-07-01 00:00:00
abstract::Current key challenges and controversies encountered in the identification of potentially hepatotoxic drugs and the assessment of drug-induced liver injury (DILI) are covered in this article. There is substantial debate over the classification of DILI itself, including the definition and validity of terms such as 'int...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/BF03261997
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:The epidemiology of naturally occurring intussusception is known to increase significantly between the ages of 3 and 8 months. Post-licensure studies have reported a fivefold and twofold increase in intussusception in the first week after the first dose and second dose, respectively, of current rotavirus v...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.1007/s40264-016-0424-y
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:While cases of amyotrophic lateral sclerosis (ALS) or ALS-like conditions have arisen in apparent association with HMG-CoA reductase inhibitors ('statins') and/or other lipid-lowering drugs (collectively termed 'statins' in this paper for brevity), additional information is needed to understand whether the c...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200932080-00004
更新日期:2009-01-01 00:00:00
abstract::Drug-induced QT interval prolongation is now a major concern in safety pharmacology. Regulatory authorities such as the US FDA and the European Medicines Agency require in vitro testing of all drug candidates against the potential risk for QT interval prolongation prior to clinical trials. Common in vitro methods incl...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200427110-00002
更新日期:2004-01-01 00:00:00
abstract::Impulse control disorders (ICDs) are a well-known adverse effect of dopamine agonists (DAAs). This critical review aims to summarize data on the prevalence and factors associated with the development of an ICD simultaneous to DAA use. A search of two electronic databases was completed from inception to July 2017. The ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-017-0590-6
更新日期:2018-01-01 00:00:00
abstract::Neuropsychiatric adverse effects related to potent antiretroviral therapy are among the complications that can lead to poor adherence, treatment interruptions, or change of antiretroviral therapy regimens. For a historical perspective, we review early literature and case reports with CNS adverse effects attributed to ...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200629100-00004
更新日期:2006-01-01 00:00:00
abstract::Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of certain forms of cancers, raising hopes for many patients with otherwise unresponsive tumours. While these agents are generally well tolerated, clinical experience with them has highlighted their unexpected association with serious toxic effects on...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.1007/s40264-013-0050-x
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Pharmacists have an essential role in improving drug usage and preventing prescribing errors (PEs). PEs at the interface of care are common, sometimes leading to adverse drug events (ADEs). This was the first study to investigate, using a computerized search method, the number, types, severity, pharmacists' ...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/11538310-000000000-00000
更新日期:2010-11-01 00:00:00
abstract::The purpose of this review is to assess the benefits and risks associated with the use of the ketolide antibacterial telithromycin, currently licensed for the treatment of adults with mild to moderate community-acquired pneumonia (CAP). Telithromycin is active against both the major (Streptococcus pneumoniae, Haemophi...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-200831070-00002
更新日期:2008-01-01 00:00:00
abstract::Cholinesterase inhibitors are currently the most established treatment strategy in Alzheimer's disease. The treatment effect appears mainly to be symptomatic. Effects on progression of the disease following long term treatment, and possible neuroprotective effects, have been investigated. Delay until nursing home plac...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199819060-00004
更新日期:1998-12-01 00:00:00
abstract::The New Zealand Medicines Adverse Reactions Committee has been monitoring reports of adverse drug reactions (ADRs) since 1965. We wished to determine the numbers of voluntary reports of different types of ADR to all nonsteroidal anti-inflammatory drugs (NSAIDs) over a long time period and relate these to age. As the e...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-199207060-00006
更新日期:1992-11-01 00:00:00
abstract::The biochemistry of vitamin K metabolism and the role of vitamin K-dependent gamma-carboxylation of the vitamin K-dependent coagulation factors are now well understood. Likewise, there is a clear understanding of the role of oral anticoagulants in the inhibition of these coagulation factors. However, the effect of ora...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199309040-00004
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:A number of published studies compare adverse event rates for drugs on the basis of reports in the US FDA Adverse Event Reporting System (AERS). While the AERS data have the advantage of timely availability and a large capture population, the database is subject to many significant biases, and lacks complete...
journal_title:Drug safety
pub_type: 杂志文章
doi:10.2165/00002018-200932020-00006
更新日期:2009-01-01 00:00:00
abstract::Cutaneous adverse drug reactions are a frequent occurrence and have been reported in more than 2% of hospitalised patients. Among the most commonly involved drugs are sulphonamides, penicillins, anticonvulsants and non-steroidal anti-inflammatory drugs. Two groups of mechanisms are involved in the pathogenesis of drug...
journal_title:Drug safety
pub_type: 杂志文章,评审
doi:10.2165/00002018-199005010-00005
更新日期:1990-01-01 00:00:00
abstract::Dental caries is defined as a pathological breakdown of the tooth. It is an infectious phenomenon involving a multifactorial aetiology. The impact of drugs on cariogenic risk has been poorly investigated. ...
journal_title:Drug safety
pub_type: 杂志文章,已发布勘误
doi:10.1007/s40264-018-0672-0
更新日期:2018-08-01 00:00:00