Evaluation of Gd-EOB-DTPA uptake in a perfused and isolated mouse liver model: correlation between magnetic resonance imaging and monochromatic quantitative computed tomography.

Abstract:

OBJECTIVES:The aim of this work was to quantitatively evaluate the pharmacokinetic pattern of Gd-EOB-DTPA in a model of isolated and perfused mouse liver by using magnetic resonance imaging (MRI) and monochromatic quantitative computed tomography (MQCT). MATERIALS AND METHODS:For MQCT, perfusions were realized with the gallbladder spared; for MRI, with gallbladder spared, severed, or clamped. Inductively coupled plasma (ICP) was performed at the end of the imaging protocols. RESULTS:MQCT, MRI, and ICP showed that perfused mice livers with spared gallbladder can be divided in 2 groups depending on their uptake profile of the contrast agent. Livers with severed gallbladders behave as the group internalizing more contrast agent, whereas Gd-EOB-DTPA uptake looks impaired in the case of a clamped gallbladder. CONCLUSIONS:For the first time, MQCT and MRI have been performed in parallel to investigate the same physiological problem. The existence of 2 liver groups seems to be the result of some instability of the protocol likely to be related to surgery.

journal_name

Invest Radiol

journal_title

Investigative radiology

authors

Segers J,Le Duc G,Laumonier C,Troprès I,Elst LV,Muller RN

doi

10.1097/01.rli.0000174474.43772.58

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

574-82

issue

9

eissn

0020-9996

issn

1536-0210

pii

00004424-200509000-00002

journal_volume

40

pub_type

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