Abstract:
OBJECTIVES:The aim of this work was to quantitatively evaluate the pharmacokinetic pattern of Gd-EOB-DTPA in a model of isolated and perfused mouse liver by using magnetic resonance imaging (MRI) and monochromatic quantitative computed tomography (MQCT). MATERIALS AND METHODS:For MQCT, perfusions were realized with the gallbladder spared; for MRI, with gallbladder spared, severed, or clamped. Inductively coupled plasma (ICP) was performed at the end of the imaging protocols. RESULTS:MQCT, MRI, and ICP showed that perfused mice livers with spared gallbladder can be divided in 2 groups depending on their uptake profile of the contrast agent. Livers with severed gallbladders behave as the group internalizing more contrast agent, whereas Gd-EOB-DTPA uptake looks impaired in the case of a clamped gallbladder. CONCLUSIONS:For the first time, MQCT and MRI have been performed in parallel to investigate the same physiological problem. The existence of 2 liver groups seems to be the result of some instability of the protocol likely to be related to surgery.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Segers J,Le Duc G,Laumonier C,Troprès I,Elst LV,Muller RNdoi
10.1097/01.rli.0000174474.43772.58keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
574-82issue
9eissn
0020-9996issn
1536-0210pii
00004424-200509000-00002journal_volume
40pub_type
杂志文章abstract:PURPOSE:To evaluate the dependency of tumor contrast enhancement (CE) in regard to protein-binding properties of contrast agents, using 4 different agents with a wide range of protein-binding capacities in a standardized rat brain glioma model. MATERIAL AND METHODS:Sixteen rats with implanted brain gliomas were evalua...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318191a334
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to implement and systematically evaluate the performance of a new parameter-free segmented algorithm for analysis of diffusion imaging data using a combined intravoxel incoherent motion and diffusion kurtosis imaging (IVIM-DKI) model of spin diffusion in comparison with the simple...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000223
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the potential of quantitative assays of vascular characteristics based on dynamic contrast-enhanced magnetic resonance imaging (MRI) using a macromolecular contrast medium (MMCM) to search for and measure effects of dimethyl sulfoxide (DMSO) on cancer vasculature with microscopic correlations. M...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318164b71d
更新日期:2008-05-01 00:00:00
abstract:RATIONAL AND OBJECTIVES:The purpose of this study was to evaluate the effects of variation in design parameters on the resultant radial force. We evaluated the influence of wire gauge, leg length, and number of bends on the radial force produced by z stents and compared these with radial forces produced by commercial s...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200109000-00004
更新日期:2001-09-01 00:00:00
abstract::Because of relatively low acute toxicity, iosulamide meglumine has been recommended as an improved contrast material for intravenous cholangiography. It has been postulated that high doses of the compound could be given safely with the expectation of achieving greater biliary excretion and improved opacification of th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198105000-00016
更新日期:1981-05-01 00:00:00
abstract:OBJECTIVE:Dynamic ventilation (3)He-MRI is a new method to assess pulmonary gas inflow. As differing airway diameters throughout the ventilatory cycle can influence gas inflow this study intends to investigate the influence of volume and timing of a He gas bolus with respect to the beginning of the tidal volume on insp...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3181690111
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:The aim was to investigate the feasibility and image quality of prospective respiratory gating for 3-D computed tomography (CT) of the lung. MATERIAL AND METHODS:Eight anesthetized pigs underwent prospectively gated multidetector computed tomography using 2 devices: a charge-coupled device (CCD) camera and a l...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000208926.98693.b6
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Nephrogenic systemic fibrosis (NSF) has been related to the use of gadolinium-based contrast agents (GBCAs) in patients undergoing dialysis. The Prospective Fibrose Nephrogénique Systémique study, a French prospective study supported by the French drug regulatory agency (Agence Nationale de Sécurité du Médic...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章
doi:10.1097/RLI.0000000000000000
更新日期:2014-02-01 00:00:00
abstract::A technique to measure absolute arterial blood flow in ml/min has been developed utilizing software programs with high-speed digital recording for the off-line analysis of intra-arterial injections of contrast medium. Measurements of pulsatile flow in a phantom for a physical flow model showed that calculations with t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198503000-00017
更新日期:1985-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the effect of the transverse ligament on translation of the menisci. METHODS:Six cadaveric knees were examined by MR imaging inside a positioning device before and after transecting the transverse ligament. The knees were examined at various positions: extension, 30 degrees of flex...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199909000-00002
更新日期:1999-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the abilities of dynamic diffusion-weighted MRI to demonstrate the effects in vivo of a high-viscosity iodinated contrast agent on medullary and cortical blood flow in the rat kidney. METHODS:Dynamic diffusion-weighted, echoplanar MR images obtained from five b-value single-shot acqu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200011000-00001
更新日期:2000-11-01 00:00:00
abstract::The rate at which isotopes descend from the cisterna magna to the lumbar subarachnoid space is highly variable. In monkeys, with and without previous lumbar puncture, transit time was measured. In animals with a previous lumbar puncture, transit times were 10 to 120 minutes; in monkeys without a previous lumbar punctu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198805000-00005
更新日期:1988-05-01 00:00:00
abstract::The developing trend for all medical images to be in digital form raises an important question: should diagnostic interpretations be made directly from a CRT or from some form of hard copy recording of the CRT? This question was studied by having two observers read a series of digital images of the thyroid including b...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198305000-00015
更新日期:1983-05-01 00:00:00
abstract::The effect of contrast media (CM) dilution on contrast enhancement was studied using CM representing four structurally different molecular types at osmolalities ranging from 135 to 1340 mosm/kg. Diatrizoate (ionic monomer), iopamidol (nonionic monomer), ioxaglate (ionic dimer), and iodecol (nonionic dimer) were each g...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198809001-00014
更新日期:1988-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Target-specific magnetic resonance (MR) contrast agents are being developed to improve the accuracy of MR imaging. The purpose of this study was to determine the mechanism of cell uptake, and modes of intracellular trafficking of a prototypical iron oxide label (RMA) used in the synthesis of so...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199510000-00006
更新日期:1995-10-01 00:00:00
abstract::A high-speed computed tomography (CT) scanner was used for measuring flow in a phantom and in the common carotid arteries of six dogs. The general ability of the scanner to assess flow using contrast media boluses was tested with the phantom. The validated simple concept was then used in the animals. The carotid blood...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198712000-00008
更新日期:1987-12-01 00:00:00
abstract::A feasibility study is described to provide quantitative texture measures to distinguish between normal lung, alveolar infiltrates and interstitial infiltrates. Advanced computer imaging technology and decision making processes were applied to distinguish between these textural patterns. The results, based on computer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197807000-00005
更新日期:1978-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance imaging (MRI) techniques to examine the effect of meningeal trauma produced by cisterna magna puncture on the integrity of the blood-cerebrospinal fluid barrier (BCB) in a rat model. METHODS:Intravenous gadolinium-DTPA (Gd-DTPA), a relaxation rate modifier w...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199204000-00008
更新日期:1992-04-01 00:00:00
abstract::Eye position recordings made while radiologists searched chest images for lung nodules showed that regions falsely reported positive or suspicious received prolonged visual attention. Correlation of regional fixation dwell time with independent ratings of image features indicated that more than 90% of false-positive d...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study evaluated the value of dynamically enhanced fast low-angle shot (FLASH) magnetic resonance (MR) imaging in measuring cardiac output with and without dipyridamole pharmacological stress. METHODS:Ten subjects underwent rest and stress MR imaging. Rest images were acquired using electr...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199611000-00003
更新日期:1996-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The reflux of ethanol into the peritoneal cavity during percutaneous ethanol injection therapy (PEIT) of liver neoplasms may cause pain and other side effects. This article studies the optimal injection technique to minimize the reflux of ethanol. METHODS:A technique using normal postmortem pi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199211000-00008
更新日期:1992-11-01 00:00:00
abstract::Compounds containing mobile protons can act as contrast agents by increasing the value of the term (1/12 - 1/11). The efficiency of this method is markedly pH- and field-dependent. There are many such compounds allowing a choice to be made based on the characteristics of the tissue or organ, magnetic field strength, a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198809001-00058
更新日期:1988-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to develop a method to delineate the lethally frozen-tissue region (temperature less than -40°C) arising from interventional cryoablation procedures using a short tau inversion-recovery ultrashort echo-time (STIR-UTE) magnetic resonance (MR) imaging sequence. This method could serve as...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000642
更新日期:2020-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Iopromide is a new monomeric, nonionic contrast agent that exhibits low osmolality and low viscosity in high concentration in aqueous solutions. Double-blind, randomized clinical trials have established the efficacy, safety, and tolerance of iopromide for excretory urography, coronary angiograp...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199405001-00015
更新日期:1994-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Two independent gold standards and diagnoses from three-dimensional computed tomography (CT) images were used to examine the possibility that craniosynostosis is a binary abnormality that potentially may be diagnosed without error. METHODS:Surgical reports, histology of excised sutures, and th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199410000-00005
更新日期:1994-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with porcine atria. METHODS:The device consists of a symmetrical cage of six superelastic monofile wires, including a mic...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199702000-00003
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to compare F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) (with and without diffusion-weighted imaging [DWI]) to F-FDG PET/computed tomography (CT), with regard to the assessment of nodal and extranodal involvement, in patients with Hodgkin lym...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000218
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the feasibility of a prototype volume-interpolated breath-hold examination (VIBE) sequence using compressed sensing (VIBECS) for rapid multiphase arterial magnetic resonance imaging (MRI) at different temporal resolution during free-breathing in comparison with a convention...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000459
更新日期:2018-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Air microemboli may damage the cerebral microvasculature. The aim of this study was to evaluate the safety of ultrasound contrast agents composed of air microspheres with regard to cerebral damage when administered into the arterial system (ie, when not filtered by the capillary system of the l...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199803000-00001
更新日期:1998-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study was devised to develop a method of measuring the acute effects of radiocontrast media on renal function and assessing the relationship of the dose of radiocontrast media infused with the incidence of radiocontrast-induced renal failure. In addition, the drug adenosine phosphate-magne...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199406000-00004
更新日期:1994-06-01 00:00:00