Abstract:
OBJECTIVE:To assess the efficacy of single, double and triple doses of 1M gadolinium in the magnetic resonance (MR) evaluation of multiple sclerosis (MS) lesions in order to establish the best trade-off in terms of dose and number of injections. MATERIALS AND METHODS:Twenty-three patients with relapsing remitting or secondary progressive MS underwent MR scans of the brain, spine or both. Signal intensity, the number of enhancing lesions and the areas of MS plaque were measured in T1-weighted images before and after single, double or triple doses of contrast medium. Wilcoxon's two-sample test and the Mann-Whitney U-test were used to evaluate the differences between the groups, and between doses in the same patient. RESULTS:There was no significant difference in area signal intensity or the number of enhancing lesions between the group examined after a single injection of double-dose (DD) contrast medium and the group examined after multiple injections of a triple dose (TD). The difference in the areas of enhancement and signal intensity between a single dose (SD) and TD significantly increased after the second bolus. CONCLUSION:Gadolinium injections in MS patients can be optimised by giving a single DD bolus, which leads to the same results as a TD administered as two boli.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Stecco A,Migazzo E,Saponaro A,Scarabino T,Tesser F,Monaco F,Carriero Adoi
10.1016/j.ejrad.2005.06.004keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
37-42issue
1eissn
0720-048Xissn
1872-7727pii
S0720-048X(05)00227-5journal_volume
57pub_type
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