A nonsteroidal follicular factor is involved in maturation process of Xenopus laevis oocytes.

Abstract:

:Xenopus laevis postvitellogenic ovarian follicles release into conditioned medium nonsteroidal factor(s) that potentiate progesterone-induced oocyte maturation. The molecular weight of this factor is between 1000 and 10,000 Da. The potentiating activity is suppressed when follicles are incubated with cyanoketone to inhibit steroidogenesis, suggesting that the secretion of the potentiating factor can be modulated in vitro. These results indicate that the steroid-independent pathway in vitro, previously reported in oocytes exposed to insulin or IGF-1 to induce meiotic resumption, may be of physiological importance.

journal_name

Gen Comp Endocrinol

authors

Chesnel F,Bourry A,Boujard D,Joly J

doi

10.1016/0016-6480(92)90115-z

keywords:

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

304-12

issue

2

eissn

0016-6480

issn

1095-6840

pii

0016-6480(92)90115-Z

journal_volume

86

pub_type

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