Abstract:
BACKGROUND:Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is lethal. In contrast, dystrophin-deficient mdx mice recover due to effective regeneration of affected muscle tissue. To characterize the molecular processes associated with regeneration, we compared gene expression levels in hindlimb muscle tissue of mdx and control mice at 9 timepoints, ranging from 1-20 weeks of age. RESULTS:Out of 7776 genes, 1735 were differentially expressed between mdx and control muscle at at least one timepoint (p < 0.05 after Bonferroni correction). We found that genes coding for components of the dystrophin-associated glycoprotein complex are generally downregulated in the mdx mouse. Based on functional characteristics such as membrane localization, signal transduction, and transcriptional activation, 166 differentially expressed genes with possible functions in regeneration were analyzed in more detail. The majority of these genes peak at the age of 8 weeks, where the regeneration activity is maximal. The following pathways are activated, as shown by upregulation of multiple members per signalling pathway: the Notch-Delta pathway that plays a role in the activation of satellite cells, and the Bmp15 and Neuregulin 3 signalling pathways that may regulate proliferation and differentiation of satellite cells. In DMD patients, only few of the identified regeneration-associated genes were found activated, indicating less efficient regeneration processes in humans. CONCLUSION:Based on the observed expression profiles, we describe a model for muscle regeneration in mdx mice, which may provide new leads for development of DMD therapies based on the improvement of muscle regeneration efficacy.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Turk R,Sterrenburg E,de Meijer EJ,van Ommen GJ,den Dunnen JT,'t Hoen PAdoi
10.1186/1471-2164-6-98keywords:
subject
Has Abstractpub_date
2005-07-13 00:00:00pages
98issn
1471-2164pii
1471-2164-6-98journal_volume
6pub_type
杂志文章相关文献
BMC GENOMICS文献大全abstract:BACKGROUND:Intergenic splicing resulting in the combination of mRNAs sequences from distinct genes is a newly identified mechanism likely to contribute to protein diversity. Few cases have been described, most of them involving neighboring genes and thus suggesting a cotranscription event presumably due to transcriptio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-71
更新日期:2006-04-04 00:00:00
abstract:BACKGROUND:The TALLYHO/Jng (TH) mouse is a polygenic model for obesity and type 2 diabetes first described in the literature in 2001. The origin of the TH strain is an outbred colony of the Theiler Original strain and mice derived from this source were selectively bred for male hyperglycemia establishing an inbred stra...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3245-6
更新日期:2016-11-11 00:00:00
abstract:BACKGROUND:Drosophila melanogaster females show changes in behavior and physiology after mating that are thought to maximize the number of progeny resulting from the most recent copulation. Sperm and seminal fluid proteins induce post-mating changes in females, however, very little is known about the resulting gene exp...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-541
更新日期:2010-10-06 00:00:00
abstract:BACKGROUND:Fistular leaves frequently appear in Allium species, and previous developmental studies have proposed that the process of fistular leaf formation involves programmed cell death. However, molecular evidence for the role of programmed cell death in the formation of fistular leaf cavities has yet to be reported...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3474-8
更新日期:2017-01-10 00:00:00
abstract:BACKGROUND:The SOS response is a well-known regulatory network present in most bacteria and aimed at addressing DNA damage. It has also been linked extensively to stress-induced mutagenesis, virulence and the emergence and dissemination of antibiotic resistance determinants. Recently, the SOS response has been shown to...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-13-58
更新日期:2012-02-03 00:00:00
abstract:BACKGROUND:The sRNAs of bacterial pathogens are known to be involved in various cellular roles including environmental adaptation as well as regulation of virulence and pathogenicity. It is expected that sRNAs may also have similar functions for Burkholderia pseudomallei, a soil bacterium that can adapt to diverse envi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-13-S7-S13
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Small insertions and deletions (InDels) constitute the second most abundant class of genetic variants and have been found to be associated with many traits and diseases. The present study reports on the detection and characterisation of about 883 K high quality InDels from the whole-genome analysis of severa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1711-1
更新日期:2015-07-31 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs that play important roles by regulating other genes. Rosa rugosa Thunb. is an important ornamental and edible plant, yet there are only a few studies on the miRNAs and their functions in R. rugosa. RESULTS:We sequenced 10 samll RNA profiles from the roots, petals...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5325-2
更新日期:2019-04-18 00:00:00
abstract:BACKGROUND:DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4353-7
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Research using the model system Xenopus laevis has provided critical insights into the mechanisms of early vertebrate development and cell biology. Large scale sequencing efforts have provided an increasingly important resource for researchers. To provide full advantage of the available sequence, we have ana...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-123
更新日期:2005-09-14 00:00:00
abstract:BACKGROUND:Sand fly saliva plays an important role in blood feeding and Leishmania transmission as it was shown to increase parasite virulence. On the other hand, immunity to salivary components impedes the establishment of infection. Therefore, it is most desirable to gain a deeper insight into the composition of sali...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-282
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:Mice of the genus Apodemus are one the most common mammals in the Palaearctic region. Despite their broad range and long history of ecological observations, there are no whole-genome data available for Apodemus, hindering our ability to further exploit the genus in evolutionary and ecological genomics contex...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6603-3
更新日期:2020-03-18 00:00:00
abstract:BACKGROUND:While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus performed full genome analyses on four Listeria monocytogenes, including human and food isolates from both a 1988 case of sporadic...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-539
更新日期:2008-11-13 00:00:00
abstract:BACKGROUND:Finger millet (Eleusine coracana (L.) Gaertn.) is an important staple food crop widely grown in Africa and South Asia. Among the millets, finger millet has high amount of calcium, methionine, tryptophan, fiber, and sulphur containing amino acids. In addition, it has C4 photosynthetic carbon assimilation mech...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3850-z
更新日期:2017-06-15 00:00:00
abstract:BACKGROUND:The desiccation-tolerant moss Bryum argenteum is an important component of the Biological Soil Crusts (BSCs) found in the Gurbantunggut desert. Desiccation tolerance is defined as the ability to revive from the air dried state. To elucidate the molecular mechanisms related to desiccation tolerance, we employ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1633-y
更新日期:2015-05-28 00:00:00
abstract:BACKGROUND:Deep-sea hydrothermal vents are unique chemoautotrophic ecosystems with harsh conditions. Alvinocaris longirostris is one of the dominant crustacean species inhabiting in these extreme environments. It is significant to clarify mechanisms in their adaptation to the vents. Lysine acetylation has been known to...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4745-3
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:Foxtail millet [Setaria italica (L.) P. Beauv.], a crop of historical importance in China, has been adopted as a model crop for studying C-4 photosynthesis, stress biology and biofuel traits. Construction of a high density genetic map and identification of stable quantitative trait loci (QTL) lay the foundat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2628-z
更新日期:2016-05-04 00:00:00
abstract:BACKGROUND:The relationships between parasitoids and their insect hosts have attracted attention at two levels. First, the basic biology of host-parasitoid interactions is of fundamental interest. Second, parasitoids are widely used as biological control agents in sustainable agricultural programs. Females of the grega...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-484
更新日期:2010-09-02 00:00:00
abstract:BACKGROUND:Magnaporthe oryzae (anamorph Pyricularia oryzae) is the causal agent of blast disease of Poaceae crops and their wild relatives. To understand the genetic mechanisms that drive host specialization of M. oryzae, we carried out whole genome resequencing of four M. oryzae isolates from rice (Oryza sativa), one ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2690-6
更新日期:2016-05-18 00:00:00
abstract:BACKGROUND:Due to the limited availability and high cost of fish oil in the face of increasing aquaculture production, there is a need to reduce usage of fish oil in aquafeeds without compromising farm fish health. Therefore, the present study was conducted to determine if different levels of vegetable and fish oils ca...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4099-2
更新日期:2017-09-08 00:00:00
abstract:BACKGROUND:Mammalian genomes contain a large number (approximately 1000) of olfactory receptor (OR) genes, many of which (20 to 50%) are pseudogenes. OR gene transcription is not restricted to the olfactory epithelium, but is found in numerous tissues. Using microarray hybridization and RTqPCR, we analyzed the mRNA pro...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-572
更新日期:2009-12-02 00:00:00
abstract:BACKGROUND:The identification of genetic markers associated with complex traits that are expensive to record such as feed intake or feed efficiency would allow these traits to be included in selection programs. To identify large-effect QTL, we performed a series of genome-wide association studies and functional analyse...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-1004
更新日期:2014-11-20 00:00:00
abstract:BACKGROUND:Horseradish peroxidases (HRPs) from Armoracia rusticana have long been utilized as reporters in various diagnostic assays and histochemical stainings. Regardless of their increasing importance in the field of life sciences and suggested uses in medical applications, chemical synthesis and other industrial ap...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-227
更新日期:2014-03-24 00:00:00
abstract:BACKGROUND:Malaria is the most important parasitic disease in the world with approximately two million people dying every year, mostly due to Plasmodium falciparum infection. During its complex life cycle in the Anopheles vector and human host, the parasite requires the coordinated and modulated expression of diverse s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-34
更新日期:2010-01-15 00:00:00
abstract:BACKGROUND:Though Illumina has largely dominated the RNA-Seq field, the simultaneous availability of Ion Torrent has left scientists wondering which platform is most effective for differential gene expression (DGE) analysis. Previous investigations of this question have typically used reference samples derived from cel...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4011-0
更新日期:2017-08-10 00:00:00
abstract:BACKGROUND:There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, and contribu...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1910-9
更新日期:2015-09-24 00:00:00
abstract:BACKGROUND:Crustaceans have been studied extensively as model systems for nervous system function from single neuron properties to behavior. However, lack of molecular sequence information and tools have slowed the adoption of these physiological systems as molecular model systems. In this study, we sequenced and perfo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3215-z
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:RNA-Seq has become increasingly popular in transcriptome profiling. One aspect of transcriptome research is to quantify the expression levels of genomic elements, such as genes, their transcripts and exons. Acquiring a transcriptome expression profile requires genomic elements to be defined in the context of...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1308-8
更新日期:2015-02-18 00:00:00
abstract:BACKGROUND:Brain and immune system are linked in a bi-directional manner. To date, it remained largely unknown why immune components become suppressed, enhanced, or remain unaffected in relation to psychosocial stress. Therefore, we mixed unfamiliar pigs with different levels of aggressiveness. We separated castrated m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-967
更新日期:2014-11-08 00:00:00
abstract:BACKGROUND:High-throughput omics technologies such as microarrays and next-generation sequencing (NGS) have become indispensable tools in biological research. Computational analysis and biological interpretation of omics data can pose significant challenges due to a number of factors, in particular the systems integrat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-514
更新日期:2013-07-29 00:00:00