Abstract:
:Three Japanese glucose 6-phosphate dehydrogenase (G6PD) variants were investigated. G6PD 'Mediterranean-like' had markedly decreased activity, normal electrophoretic mobility, low Km G6P, low Km NADP, increased utilization of all three substrate analogues (2-deoxy-G6P, Gal-6P, and deamino-NADP) and slightly decreased heat stability and slightly biphasic pH curve. G6PD 'Ogori' had markedly decreased activity, but otherwise normal characteristics. G6PD 'Hofu' had moderately decreased activity, normal electrophoretic mobility, slightly reduced Km G6P, normal Km NADP, normal utilization of 2-deoxy-G6P and Gal-6P, but increased utilization of deamino-NADP and normal heat stability as well as normal pH curve.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Miwa SH,Nakashima K,Ono J,Fujii H,Suzuki Edoi
10.1007/BF00446284keywords:
subject
Has Abstractpub_date
1977-05-10 00:00:00pages
327-34issue
3eissn
0340-6717issn
1432-1203journal_volume
36pub_type
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