当前位置： SCI文献检索 > EXPERIMENTAL CELL RESEARCH期刊下所有文献 > Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation.

Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation.

Abstract：

:Ovarian cancer (OC) is the leading cause of death in gynecologic diseases in which there is evidence for a complex chemokine network. Chemokines are a family of proteins that play an important role in tumor progression influencing cell proliferation, angiogenic/angiostatic processes, cell migration and metastasis, and, finally, regulating the immune cells recruitment into the tumor mass. We previously demonstrated that astrocytes and glioblastoma cells express both the chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1), and that SDF-1alpha treatment induced cell proliferation, supporting the hypothesis that chemokines may play an important role in tumor cells' growth in vitro. In the present study, we report that CXCR4 and SDF-1 are expressed in OC cell lines. We demonstrate that SDF-1alpha induces a dose-dependent proliferation in OC cells, by the specific interaction with CXCR4 and a biphasic activation of ERK1/2 and Akt kinases. Our results further indicate that CXCR4 activation induces EGF receptor (EGFR) phosphorylation that in turn was linked to the downstream intracellular kinases activation, ERK1/2 and Akt. In addition, we provide evidence for cytoplasmic tyrosine kinase (c-Src) involvement in the SDF-1/CXCR4-EGFR transactivation. These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer.

journal_name

Exp Cell Res

journal_title

Experimental cell research

authors

Porcile C,Bajetto A,Barbieri F,Barbero S,Bonavia R,Biglieri M,Pirani P,Florio T,Schettini G

doi

10.1016/j.yexcr.2005.04.024

keywords:

subject

Has Abstract

pub_date

2005-08-15 00:00:00

pages

241-53

issue

2

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(05)00197-7

journal_volume

308

pub_type

杂志文章

相关文献

EXPERIMENTAL CELL RESEARCH文献大全
  • Tumor-specific induction of apoptosis by a p53-reactivating compound.

    abstract：:The tumor suppressor function of p53 is disabled in the majority of tumors, either by a point mutation of the p53 gene, or via MDM2-dependent proteasomal degradation. We have screened a chemical library using a cell-based assay and identified a low molecular weight compound named MITA which induced wild-type p53-depen...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2008.11.009

    authors： Hedström E,Issaeva N,Enge M,Selivanova G

    更新日期：2009-02-01 00:00:00

  • In vitro DNA-damaging effects of intestinal and related tetrapyrroles in human cancer cells.

    abstract：:Epidemiological studies report a negative association between circulating bilirubin concentrations and the risk for cancer and cardiovascular disease. Structurally related tetrapyrroles also possess in vitro anti-genotoxic activity and may prevent mutation prior to malignancy. Furthermore, few data suggest that tetrap...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2012.12.003

    authors： Mölzer C,Pfleger B,Putz E,Roßmann A,Schwarz U,Wallner M,Bulmer AC,Wagner KH

    更新日期：2013-02-15 00:00:00

  • NF-κB mediated miR-130a modulation in lung microvascular cell remodeling: Implication in pulmonary hypertension.

    abstract：:Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease which is associated with pulmonary arterial endothelial cells (PAEC) dysfunction and pulmonary arterial smooth muscle cells proliferation. Moreover, inflammation is contributing a critical role in EC dysfunction and remains elusive. Nucl...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2017.07.024

    authors： Li L,Kim IK,Chiasson V,Chatterjee P,Gupta S

    更新日期：2017-10-01 00:00:00

  • The functional domains for Bax∆2 aggregate-mediated caspase 8-dependent cell death.

    abstract：:Bax∆2 is a functional pro-apoptotic Bax isoform having alterations in its N-terminus, but sharing the rest of its sequence with Baxα. Bax∆2 is unable to target mitochondria due to the loss of helix α1. Instead, it forms cytosolic aggregates and activates caspase 8. However, the functional domain(s) responsible for Bax...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2017.08.016

    authors： Mañas A,Wang S,Nelson A,Li J,Zhao Y,Zhang H,Davis A,Xie B,Maltsev N,Xiang J

    更新日期：2017-10-15 00:00:00

  • Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: a role for NF-κB-STAT3-directed gene expression.

    abstract：:Mitochondrial DNA depleted (ρ(0)) human skin fibroblasts (HSF) with suppressed oxidative phosphorylation were characterized by significant changes in the expression of 2100 nuclear genes, encoding numerous protein classes, in NF-κB and STAT3 signaling pathways, and by decreased activity of mitochondrial death pathway,...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2011.03.012

    authors： Ivanov VN,Ghandhi SA,Zhou H,Huang SX,Chai Y,Amundson SA,Hei TK

    更新日期：2011-07-01 00:00:00

  • Synthesis and fate of keratins 8 and 18 in nonepithelial cells transfected with cDNA.

    abstract：:To study the assembly of intermediate filaments in vivo we have transfected fibroblast cell lines with the cDNAs coding for keratins 8 and 18 under the control of the promoter of the SV40 early region and followed keratin expression by RNA hybridization, two-dimensional gel electrophoresis, and immunofluorescence anal...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(88)90274-1

    authors： Domenjoud L,Jorcano JL,Breuer B,Alonso A

    更新日期：1988-12-01 00:00:00

  • Cytochemical localization of adenylate cyclase in bovine cumulus-oocyte complexes.

    abstract：:The ultrastructural localization of adenylate cyclase was studied in bovine cumulus-oocyte complexes. Adenylate cyclase was observed on the plasma membrane of the oocyte and occasionally on the plasma membrane of cumulus cells. The cytochemical observations presented demonstrate that there is more adenylate cyclase in...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(88)90149-8

    authors： Kuyt JR,Kruip TA,de Jong-Brink M

    更新日期：1988-01-01 00:00:00

  • p21ras. Heterogeneous localization in transformed cells.

    abstract：:The cellular targets for the Kirsten murine sarcoma virus (KiMSV)-transforming protein, p21ras, are unknown. Other studies have indicated that the mature form of p21 is distributed diffusely on the cytoplasmic face of the plasma membrane. However, after fixation without buffer washes, indirect immunofluorescent staini...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/s0014-4827(85)80017-3

    authors： Myrdal SE,Auersperg N

    更新日期：1985-08-01 00:00:00

  • Immunofluorescent localization of histone H10 in the nuclei of proliferating and differentiating Friend cells.

    abstract：:By using affinity-purified antibodies to H10 and to H1AB the localization of these histones was studied by indirect immunofluorescence in the nuclei of proliferating (EAT and uninduced Friend cells) and of differentiating (induced Friend cells) cell populations. While with H1AB antibodies a bright fluorescence all ove...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(88)90019-5

    authors： Banchev T,Srebreva L,Zlatanova J,Tsanev R

    更新日期：1988-07-01 00:00:00

  • Acceleration of cytokinesis in PtK1 cells treated with microtubule inhibitors.

    abstract：:Mitotic PtK1 cells were treated at furrow initiation with microtubule poisons to determine the role of microtubules in the regulation of terminal cytokinetic events. The administration of anti-microtubule agents in late anaphase accelerated the rate of cytokinesis by approx. 60% as measured by changes in furrow diamet...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(83)90413-5

    authors： Hamilton BT,Snyder JA

    更新日期：1983-04-01 00:00:00

  • Diacytosis of human asialotransferrin type 3 in the rat liver is due to the sequential engagement of two receptors.

    abstract：:The possible role of transferrin receptors in the diacytosis of human asialotransferrin type 3 (HAsTf-3) by the rat liver was studied in vivo. A trace dose of the ligand was allowed to compete for hepatic binding sites against diferric transferrin, the concentration of which was varied between 5 400- and 18 000-fold. ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(85)90230-7

    authors： Regoeczi E,Koj A

    更新日期：1985-09-01 00:00:00

  • Identification of PML oncogenic domains (PODs) in human megakaryocytes.

    abstract：:Megakaryocytes (Mks) are unique cells in the human body in that they carry a single and polyploid nucleus. It is therefore of interest to understand their nuclear ultrastructure. PML oncogenic domains (PODs) were described in several types of eukaryotic cells using human autoantibodies which recognize nuclear antigens...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.2001.5377

    authors： Drouin A,Schmitt A,Massé JM,Cieutat AM,Fichelson S,Cramer EM

    更新日期：2001-12-10 00:00:00

  • Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes.

    abstract：:Keratinocyte growth factor (KGF/FGF7) and fibroblast growth factor 10 (FGF10/KGF2) regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR). KGF induces keratinocyte motility and cytoskeletal rearrangement, whereas a direct role of FGF10 on keratinocyte migration is...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2007.03.013

    authors： Ceccarelli S,Cardinali G,Aspite N,Picardo M,Marchese C,Torrisi MR,Mancini P

    更新日期：2007-05-15 00:00:00

  • The nucleoside diphosphate kinase activity of DRnm23 is not required for inhibition of differentiation and induction of apoptosis in 32Dcl3 myeloid precursor cells.

    abstract：:DRnm23 belongs to a multigene family which includes nm23-H1, the first bona fide metastasis suppressor gene, nm23-H2, nm23-H4, and nm23-H5. Like nm23-H1, nm23-H2, and nm23-H4, DRnm23 possesses nucleoside diphosphate kinase (NDPK) activity. Upon overexpression in myeloid precursor 32Dcl3 cells, DRnm23 inhibits granuloc...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.2000.4899

    authors： Venturelli D,Cesi V,Ransac S,Engelhard A,Perrotti D,Calabretta B

    更新日期：2000-06-15 00:00:00

  • Identification of a 55-kDa ezrin-related protein that induces cytoskeletal changes and localizes to the nucleolus.

    abstract：:Normal and transformed human cells when stained for ezrin, an F-actin-binding ERM (ezrin/radixin/moesin) family protein, revealed a faint and intense immunofluorescence, respectively. Surprisingly, nuclear staining that was assigned to the nucleolus by confocal laser and immunoelectron microscopy was detected in both ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1999.4491

    authors： Kaul SC,Kawai R,Nomura H,Mitsui Y,Reddel RR,Wadhwa R

    更新日期：1999-07-10 00:00:00

  • Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes: effect of age and dietary restriction.

    abstract：:The ability of primary cultures of rat hepatocytes to remove cyclobutane pyrimidine dimers (CPDs) from DNA fragments containing the transcriptionally active albumin gene and the transcriptionally inactive embryonic myosin heavy chain (MHCemb) and H-ras fragments as well as the genome overall was measured. At all UV do...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1998.4269

    authors： Guo Z,Heydari A,Richardson A

    更新日期：1998-11-25 00:00:00

  • TGF-beta induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways.

    abstract：:Transforming growth factor beta regulates many biological processes including cell motility and invasion. Podosomes are specialized F-actin rich structures found in normal cells, such as osteoclasts and macrophages. Tumor cells often form related structures called invadopodia that are thought to promote invasion and m...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2008.09.013

    authors： Mandal S,Johnson KR,Wheelock MJ

    更新日期：2008-11-15 00:00:00

  • Long-term cultivation of amphibian melanophores. In vitro ageing and spontaneous transformation to a continuous cell line.

    abstract：:Pure melanophore populations isolated from the tail skin of the tadpole, Rana catesbeiana, were mass cultured for a period of 2-3 years. All cell lines of amphibian melanophores studied exhibited growth crisis (in vitro ageing) followed by spontaneous transformation to a continuous cell line, as shown by changes in gr...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(83)90396-8

    authors： Kondo H,Ide H

    更新日期：1983-11-01 00:00:00

  • Toxic peptides in Frazer's fraction interact with the actin cytoskeleton and affect the targeting and function of intestinal proteins.

    abstract：:Celiac disease (CD) is a multisystemic autoimmune inflammation of the intestinal tract induced by wheat gluten and related cereals in HLA-DQ2/8 positive individuals. An essential role in the pathogenesis of CD is played by a fraction of the peptic-tryptic digest of gluten, Frazer's Fraction (FF). Here, we investigate ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2009.06.026

    authors： Reinke Y,Zimmer KP,Naim HY

    更新日期：2009-11-15 00:00:00

  • Mitotic segregation of the nucleolar ribosomal RNA in Physarum polycephalum.

    abstract：:In the naturally synchronous mitosis of the syncytial plasmodium of Physarum polycephalum, the nucleolus disintegrates in prophase, releasing a large amount of ribosomal RNA. Using biotinylated rDNA probes, we studied by high-resolution in situ hybridization the behavior of this nucleolar RNA throughout mitosis. Our r...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1993.1274

    authors： Pierron G,Puvion-Dutilleul F

    更新日期：1993-10-01 00:00:00

  • Modulation of the phosphorylation of glucose-regulated protein, GRP78, by transformation and inhibition of glycosylation.

    abstract：:The phosphorylation of glucose-regulated protein, GRP78, is thought to be involved in the regulation of the binding function of GRP78 to immunoglobulin heavy chains. The phosphorylation of GRP78 proceeded faster in transformed cells than in normal cells, whereas the levels of GRP78 synthesis and accumulation were simi...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1993.1060

    authors： Satoh M,Nakai A,Sokawa Y,Hirayoshi K,Nagata K

    更新日期：1993-03-01 00:00:00

  • Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways.

    abstract：:Mutations in PKHD1 (polycystic kidney and hepatic disease gene 1) gene cause the autosomal recessive polycystic kidney disease (ARPKD). Fibrocystin/polyductin (FPC), encoded by PKHD1, is a membrane-associated receptor-like protein. Although it is widely accepted that cystogenesis is mostly due to aberrant cell prolife...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2011.01.025

    authors： Sun L,Wang S,Hu C,Zhang X

    更新日期：2011-04-15 00:00:00

  • Profilin I colocalizes with speckles and Cajal bodies: a possible role in pre-mRNA splicing.

    abstract：:Profilin is one of the major components controlling actin polymerization. Here, profilin I was located in fibroblasts and HeLa cells by the use of two different sets of affinity-purified antibodies. Both antibody preparations labeled nuclei in a speckle-like pattern and displayed extensive colocalization with small nu...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/s0014-4827(03)00102-2

    authors： Skare P,Kreivi JP,Bergström A,Karlsson R

    更新日期：2003-05-15 00:00:00

  • Effects of polyamines on the first division cycle of Xenopus laevis eggs.

    abstract：:The involvement of polyamines in cytokinesis has been examined in eggs of the amphibian X. laevis. Microinjection of spermine or spermidine into unfertilized eggs induced a shortening of the first division cycle and early formation of cleavage-like constrictions. Eggs were activated by injection and developed furrows ...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(84)90593-7

    authors： Grant NJ,Aimar C,Oriol-Audit C

    更新日期：1984-02-01 00:00:00

  • Coordination of growth and differentiation in the fetal lung.

    abstract：:The male fetal lung begins to synthesize surfactant later in gestation than the female. This delay appears to be caused by androgens. We hypothesized that male fetal lung differentiation is delayed as a consequence of an extended phase of growth which is elicited by androgens. We observed that in vivo fetal lung prote...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(90)90281-e

    authors： Nielsen HC,Kirk WO,Sweezey N,Torday JS

    更新日期：1990-05-01 00:00:00

  • The role of HGF on invasive properties and repopulation potential of human fetal hepatic progenitor cells.

    abstract：UNLABELLED:The success of hepatocyte transplantation has been limited by the low efficiency of transplanted cell integration into liver parenchyma. Human fetal hepatic progenitor cells (hepatoblasts) engraft more effectively than adult hepatocytes in mouse livers. However, the signals required for their integration are...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/j.yexcr.2009.07.007

    authors： Delgado JP,Vanneaux V,Branger J,Touboul T,Sentilhes L,Mainot S,Lainas P,Leclerc P,Uzan G,Mahieu-Caputo D,Weber A

    更新日期：2009-11-15 00:00:00

  • Immunological visualization of 5-methylcytosine-rich regions in Indian Muntjac metaphase chromosomes.

    abstract：:Regions rich in 5-methylcytosine were localized in male metaphase chromosomes of the Indian muntjac deer (Muntiakus muntjak). Chromosomes were ultraviolet irradiated and subsequently photooxidized in the presence of methylene blue to induce maximum DNA denaturation. Following treatment with anti 5-methylcytosine antib...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(83)90289-6

    authors： Vasilikaki-Baker H,Nishioka Y

    更新日期：1983-08-01 00:00:00

  • Rap G protein signal in normal and disordered lymphohematopoiesis.

    abstract：:Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins inclu...

    journal_title：Experimental cell research

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexcr.2013.04.009

    authors： Minato N

    更新日期：2013-09-10 00:00:00

  • Recombinant bone morphogenetic protein-4, transforming growth factor-beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro.

    abstract：:Bone morphogenetic protein-4 (BMP-4) is a member of the transforming growth factor-beta (TGF-beta) supergene family and is characterized by its ability to induce singly de novo cartilage and bone in vivo. The influence of recombinant bone morphogenetic protein-4 and some related members, TGF-beta 1, activin A, and inh...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1006/excr.1994.1033

    authors： Luyten FP,Chen P,Paralkar V,Reddi AH

    更新日期：1994-02-01 00:00:00

  • Developmental kinetics of hemopoietic progenitors in the avian embryo spleen.

    abstract：:By means of plasma clot clonal cultures, the content of the avian spleen in granulomonocytic progenitors was studied during ontogeny. Serum-free media were used that were supplemented with growth activities produced either by embryonic fibroblasts or adult spleen cells. These two conditioned media not only permitted t...

    journal_title：Experimental cell research

    pub_type： 杂志文章

    doi：10.1016/0014-4827(91)90264-u

    authors： Nicolas-Bolnet C,Yassine F,Cormier F,Dieterlen-Lièvre F

    更新日期：1991-10-01 00:00:00